Zfp58 zinc finger protein 58 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp58provided by MGI
Official Full Name: zinc finger protein 58provided by MGI
Primary source: MGI:MGI:99205
See related: Ensembl:ENSMUSG00000071291 AllianceGenome:MGI:99205
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mfg1; Mfg-1; Zfp817; Rslcan5; A530094I17Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF429 (zinc finger protein 429). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 2.7), bladder adult (RPKM 2.6) and 24 other tissues See more
Orthologs: all
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Genomic context

Location:: 13 B3; 13 34.54 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (67638286..67648641, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (67490167..67500522, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 58

Names: KRAB zinc finger protein; regulator of sex-limitation candidate 5; zfp-58; zinc finger protein 817; zinc finger protein Mfg-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007575.2 → NP_001007576.1 zinc finger protein 58

See identical proteins and their annotated locations for NP_001007576.1

Status: VALIDATED

Source sequence(s)

AV282347, BK001635, CJ204655, DV071305

Consensus CDS

CCDS26616.1

UniProtKB/Swiss-Prot

P16372, Q3TS54, Q6P8L3, Q7M6X1, Q8BRV1

Related

ENSMUSP00000075487.6, ENSMUST00000076123.12

Conserved Domains (5) summary

smart00349
Location:2 → 61

KRAB; krueppel associated box

COG5048
Location:106 → 489

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:108 → 128

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:2 → 41

KRAB; KRAB box

pfam13465
Location:176 → 201

zf-H2C2_2; Zinc-finger double domain