U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Usp32 ubiquitin specific peptidase 32 [ Mus musculus (house mouse) ]

Gene ID: 237898, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Usp32provided by MGI
Official Full Name
ubiquitin specific peptidase 32provided by MGI
Primary source
MGI:MGI:2144475
See related
Ensembl:ENSMUSG00000000804 AllianceGenome:MGI:2144475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900074J03Rik; 6430526O11Rik
Summary
Predicted to enable thiol-dependent deubiquitinase. Predicted to be located in cytosol; plasma membrane; and recycling endosome. Predicted to be active in Golgi apparatus. Is expressed in choroid plexus; cranial ganglion; and dorsal root ganglion. Orthologous to several human genes including USP32 (ubiquitin specific peptidase 32). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 14.5), liver E14.5 (RPKM 12.8) and 24 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 C; 11 51.34 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84875263..85031107, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84984437..85140281, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33028 Neighboring gene predicted gene, 32917 Neighboring gene carbonic anhydrase 4 Neighboring gene STARR-positive B cell enhancer ABC_E5257 Neighboring gene STARR-seq mESC enhancer starr_30231 Neighboring gene STARR-seq mESC enhancer starr_30232 Neighboring gene 60S ribosomal protein L18 pseudogene Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial pseudogene Neighboring gene ribosomal protein L13, pseudogene 1 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30233 Neighboring gene STARR-positive B cell enhancer ABC_E7034 Neighboring gene STARR-seq mESC enhancer starr_30234 Neighboring gene CHD1 helical C-terminal domain containing 1 Neighboring gene predicted gene, 23506 Neighboring gene amyloid beta precursor protein binding protein 2 Neighboring gene predicted gene, 51947

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. USP32 is an active, membrane-bound ubiquitin protease overexpressed in breast cancers. Akhavantabasi S, et al. Mamm Genome, 2010 Aug. PMID 20549504
  2. Gene Essentiality Profiling Reveals Gene Networks and Synthetic Lethal Interactions with Oncogenic Ras. Wang T, et al. Cell, 2017 Feb 23. PMID 28162770, Free PMC Article
  3. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
  4. Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Thuret S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033168
  5. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquitin carboxyl-terminal hydrolase 32
Names
deubiquitinating enzyme 32
ubiquitin specific protease 32
ubiquitin thioesterase 32
ubiquitin-specific-processing protease 32
NP_001025105.1
XP_011247292.1
XP_011247293.1
XP_030101829.1
XP_030101830.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029934.1 → NP_001025105.1  ubiquitin carboxyl-terminal hydrolase 32

    See identical proteins and their annotated locations for NP_001025105.1

    Status: VALIDATED

    Source sequence(s)
    AL596183, AL669859, BC058994
    Consensus CDS
    CCDS36264.1
    UniProtKB/Swiss-Prot
    F8VPZ3, Q3US74, Q6PD17, Q7TT84, Q8CCP4
    Related
    ENSMUSP00000103710.3, ENSMUST00000108075.9
    Conserved Domains (6) summary
    COG5560
    Location:518 → 1316
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    cd00051
    Location:237 → 293
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cl02553
    Location:1225 → 1565
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam06337
    Location:519 → 586
    DUSP; DUSP domain
    pfam13499
    Location:236 → 293
    EF-hand_7; EF-hand domain pair
    pfam14836
    Location:623 → 710
    Ubiquitin_3; Ubiquitin-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    84875263..85031107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245970.1 → XP_030101830.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X3

    Conserved Domains (3) summary
    COG5126
    Location:148 → 298
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    COG5560
    Location:477 → 1275
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    pfam00443
    Location:1193 → 1523
    UCH; Ubiquitin carboxyl-terminal hydrolase

  2. XM_011248990.1 → XP_011247292.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X1

    Conserved Domains (3) summary
    COG5126
    Location:189 → 339
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    COG5560
    Location:518 → 1330
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    pfam00443
    Location:1248 → 1578
    UCH; Ubiquitin carboxyl-terminal hydrolase

  3. XM_030245969.2 → XP_030101829.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X2

    Conserved Domains (3) summary
    COG5126
    Location:148 → 298
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    COG5560
    Location:477 → 1289
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
    pfam00443
    Location:1207 → 1537
    UCH; Ubiquitin carboxyl-terminal hydrolase

  4. XM_011248991.1 → XP_011247293.1  ubiquitin carboxyl-terminal hydrolase 32 isoform X4

    Conserved Domains (2) summary
    COG5126
    Location:189 → 339
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    COG5560
    Location:518 → 910
    UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F8VPZ3.1 GenPept UniProtKB/Swiss-Prot:F8VPZ3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous