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Sarm1 sterile alpha and HEAT/Armadillo motif containing 1 [ Mus musculus (house mouse) ]

Gene ID: 237868, updated on 11-Apr-2024

Summary

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Official Symbol
Sarm1provided by MGI
Official Full Name
sterile alpha and HEAT/Armadillo motif containing 1provided by MGI
Primary source
MGI:MGI:2136419
See related
Ensembl:ENSMUSG00000050132 AllianceGenome:MGI:2136419
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sarm; MyD885; A830091I15Rik
Summary
Enables NAD+ nucleosidase activity. Involved in NAD catabolic process; positive regulation of neuron death; and regulation of dendrite morphogenesis. Acts upstream of or within regulation of apoptotic process and response to glucose. Located in several cellular components, including dendrite; microtubule; and mitochondrion. Is extrinsic component of mitochondrial outer membrane. Is expressed in immune system; nervous system; neural retina; and tongue. Orthologous to human SARM1 (sterile alpha and TIR motif containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in whole brain E14.5 (RPKM 11.0), CNS E18 (RPKM 9.7) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 46.74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (78361099..78388642, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (78470273..78497816, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30367 Neighboring gene forkhead box N1 Neighboring gene solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2, opposite strand Neighboring gene solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 Neighboring gene solute carrier family 46, member 1 Neighboring gene STARR-positive B cell enhancer ABC_E10695 Neighboring gene SEBOX homeobox Neighboring gene vitronectin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SARM1 promotes the neuroinflammation and demyelination through IGFBP2/NF-κB pathway in experimental autoimmune encephalomyelitis mice. Zhang J, et al. Acta Physiol (Oxf), 2023 Jun. PMID 37186158
  2. Sarm1 Regulates Circadian Rhythm Disorder in Alzheimer's Disease in Mice. Wang Z, et al. J Alzheimers Dis, 2023. PMID 36776065
  3. Base-Exchange Enabling the Visualization of SARM1 Activities in Sciatic Nerve-Injured Mice. Huang K, et al. ACS Sens, 2023 Feb 24. PMID 36689294, Free PMC Article
  4. Traumatic axonopathy in spinal tracts after impact acceleration head injury: Ultrastructural observations and evidence of SARM1-dependent axonal degeneration. Alexandris AS, et al. Exp Neurol, 2023 Jan. PMID 36244414, Free PMC Article
  5. Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease. Bratkowski M, et al. Neuron, 2022 Nov 16. PMID 36087583

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons.
    Title: SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons.
  2. SARM1 regulates NAD[+]-linked metabolism and select immune genes in macrophages.
    Title: SARM1 regulates NAD(+)-linked metabolism and select immune genes in macrophages.
  3. Sarm1 knockout prevents type 1 diabetic bone disease in females independent of neuropathy.
    Title: Sarm1 knockout prevents type 1 diabetic bone disease in females independent of neuropathy.
  4. Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma.
    Title: Loss of Sarm1 reduces retinal ganglion cell loss in chronic glaucoma.
  5. Loss of SARM1 ameliorates secondary thalamic neurodegeneration after cerebral infarction.
    Title: Loss of SARM1 ameliorates secondary thalamic neurodegeneration after cerebral infarction.
  6. SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease.
    Title: SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease.
  7. Targeting SARM1 improves autophagic stress-induced axonal neuropathy.
    Title: Targeting SARM1 improves autophagic stress-induced axonal neuropathy.
  8. Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury.
    Title: Genetic ablation of Sarm1 attenuates expression and mislocalization of phosphorylated TDP-43 after mouse repetitive traumatic brain injury.
  9. SARM1 deletion delays cerebellar but not spinal cord degeneration in an enhanced mouse model of SPG7 deficiency.
    Title: SARM1 deletion delays cerebellar but not spinal cord degeneration in an enhanced mouse model of SPG7 deficiency.
  10. Traumatic Axonal Injury in the Optic Nerve: The Selective Role of SARM1 in the Evolution of Distal Axonopathy.
    Title: Traumatic Axonal Injury in the Optic Nerve: The Selective Role of SARM1 in the Evolution of Distal Axonopathy.
Submit: New GeneRIF Correction See all GeneRIFs (81)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ nucleosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+ nucleosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables NAD+ nucleotidase, cyclic ADP-ribose generating ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NAD catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NAD catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in NAD catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of MyD88-independent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse pruning IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse pruning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to axon injury ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to glucose IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
NAD(+) hydrolase SARM1
Names
NADP(+) hydrolase SARM1
NADase SARM1
Tir-1 homolog
sterile alpha and TIR motif containing 1
sterile alpha and TIR motif-containing protein 1
NP_001161993.1
NP_766383.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168521.1 → NP_001161993.1  NAD(+) hydrolase SARM1 isoform 1

    See identical proteins and their annotated locations for NP_001161993.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL591177, BC080850, BU704378
    Consensus CDS
    CCDS48857.1
    UniProtKB/TrEMBL
    A0PJL3
    Related
    ENSMUSP00000103922.4, ENSMUST00000108287.10
    Conserved Domains (4) summary
    cd09501
    Location:409 → 477
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:479 → 544
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:409 → 476
    SAM; Sterile alpha motif
    smart00255
    Location:601 → 742
    TIR; Toll - interleukin 1 - resistance

  2. NM_172795.3 → NP_766383.2  NAD(+) hydrolase SARM1 isoform 2

    See identical proteins and their annotated locations for NP_766383.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL591177, BC080850
    Consensus CDS
    CCDS25105.1
    UniProtKB/Swiss-Prot
    Q5SYG5, Q5SYG6, Q6A054, Q6PDS3, Q6SZW0, Q8BRI9
    UniProtKB/TrEMBL
    A0PJL3
    Related
    ENSMUSP00000051059.7, ENSMUST00000061174.7
    Conserved Domains (4) summary
    cd09501
    Location:409 → 477
    SAM_SARM1-like_repeat1; SAM domain ot SARM1-like proteins, repeat 1
    cd09502
    Location:479 → 547
    SAM_SARM1-like_repeat2; SAM domain of SARM1-like, repeat 2
    smart00454
    Location:409 → 476
    SAM; Sterile alpha motif
    smart00255
    Location:561 → 702
    TIR; Toll - interleukin 1 - resistance

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    78361099..78388642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001780001.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDS3.1 GenPept UniProtKB/Swiss-Prot:Q6PDS3

Gene LinkOut

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