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Lrrc3 leucine rich repeat containing 3 [ Mus musculus (house mouse) ]

Gene ID: 237387, updated on 5-Mar-2024

Summary

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Official Symbol
Lrrc3provided by MGI
Official Full Name
leucine rich repeat containing 3provided by MGI
Primary source
MGI:MGI:2447899
See related
Ensembl:ENSMUSG00000051652 AllianceGenome:MGI:2447899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C21orf102; 1300011L04Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Orthologous to human LRRC3 (leucine rich repeat containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 12.5), liver E18 (RPKM 4.4) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 C1; 10 39.72 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77733409..77738370, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (77897575..77902536, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene thrombospondin type laminin G domain and EAR repeats Neighboring gene keratin associated protein 10-24 Neighboring gene RIKEN cDNA 1700009J07 gene Neighboring gene predicted gene, 53590 Neighboring gene predicted gene, 22394 Neighboring gene transient receptor potential cation channel, subfamily M, member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nineteen additional unpredicted transcripts from human chromosome 21. Reymond A, et al. Genomics, 2002 Jun. PMID 12036297
  2. PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Yoshida Y, et al. Neuron, 2006 Dec 7. PMID 17145500, Free PMC Article
  3. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
  4. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145152.4 → NP_660134.1  leucine-rich repeat-containing protein 3 precursor

    See identical proteins and their annotated locations for NP_660134.1

    Status: VALIDATED

    Source sequence(s)
    AC153874, AC158612, AY061858, BQ176232, BY320829
    Consensus CDS
    CCDS23960.1
    UniProtKB/Swiss-Prot
    P59034
    UniProtKB/TrEMBL
    Q543Z4
    Related
    ENSMUSP00000059570.5, ENSMUST00000057608.5
    Conserved Domains (4) summary
    smart00013
    Location:33 → 68
    LRRNT; Leucine rich repeat N-terminal domain
    sd00031
    Location:48 → 68
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:88 → 129
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:69 → 125
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    77733409..77738370 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59034.1 GenPept UniProtKB/Swiss-Prot:P59034

Gene LinkOut

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