U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lrp11 low density lipoprotein receptor-related protein 11 [ Mus musculus (house mouse) ]

Gene ID: 237253, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Lrp11provided by MGI
Official Full Name
low density lipoprotein receptor-related protein 11provided by MGI
Primary source
MGI:MGI:2442989
See related
Ensembl:ENSMUSG00000019796 AllianceGenome:MGI:2442989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330533B21; 1700034J19Rik; 9830160H19Rik
Summary
Predicted to enable phosphoprotein binding activity. Acts upstream of or within several processes, including response to cold; response to immobilization stress; and response to water deprivation. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in alimentary system; nervous system; sensory organ; and smooth muscle tissue. Orthologous to human LRP11 (LDL receptor related protein 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 29.4), cortex adult (RPKM 27.0) and 10 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10 A1; 10 2.23 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (7465532..7501247)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (7589817..7624768)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 21321 Neighboring gene UL16 binding protein 1 Neighboring gene predicted gene, 46209 Neighboring gene STARR-positive B cell enhancer ABC_E3874 Neighboring gene predicted gene 16254 Neighboring gene STARR-seq mESC enhancer starr_25682 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 Neighboring gene RIKEN cDNA A630066F11 gene Neighboring gene STARR-positive B cell enhancer ABC_E3875 Neighboring gene nucleoporin 43

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic regulatory network analysis reveals that low density lipoprotein receptor-related protein 11 is involved in stress responses in mice. Xu J, et al. Psychiatry Res, 2014 Dec 30. PMID 25262641
  2. Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Pereira JD, et al. Proc Natl Acad Sci U S A, 2010 Sep 7. PMID 20798045, Free PMC Article
  3. Insm1 promotes endocrine cell differentiation by modulating the expression of a network of genes that includes Neurog3 and Ripply3. Osipovich AB, et al. Development, 2014 Aug. PMID 25053427, Free PMC Article
  4. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Hald J, et al. Diabetologia, 2012 Jan. PMID 21947380
  5. Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Memic F, et al. Gastroenterology, 2018 Feb. PMID 29031500, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organismal response to stress IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to immobilization stress IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to water deprivation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
low-density lipoprotein receptor-related protein 11
Names
LRP-11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359742.2 → NP_001346671.1  low-density lipoprotein receptor-related protein 11 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC156391, FO907139
    UniProtKB/TrEMBL
    D3Z3A7
    Conserved Domains (2) summary
    smart00765
    Location:69 → 172
    MANEC; The MANEC domain, formerly called MANSC
    smart00089
    Location:191 → 280
    PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins

  2. NM_001359743.2 → NP_001346672.1  low-density lipoprotein receptor-related protein 11 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC156391, FO907139
    Consensus CDS
    CCDS87955.1
    UniProtKB/TrEMBL
    D3Z2B1, D3Z3A7
    Related
    ENSMUSP00000121704.2, ENSMUST00000130590.8
    Conserved Domains (3) summary
    smart00765
    Location:69 → 172
    MANEC; The MANEC domain, formerly called MANSC
    smart00089
    Location:191 → 280
    PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
    cd00112
    Location:294 → 328
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  3. NM_001359744.2 → NP_001346673.1  low-density lipoprotein receptor-related protein 11 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC156391, FO907139
    UniProtKB/TrEMBL
    F7AX87
    Related
    ENSMUSP00000122359.2, ENSMUST00000135907.8
    Conserved Domains (1) summary
    smart00765
    Location:69 → 172
    MANEC; The MANEC domain, formerly called MANSC

  4. NM_001379151.1 → NP_001366080.1  low-density lipoprotein receptor-related protein 11 isoform 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
    Source sequence(s)
    AC156391, FO907139
    UniProtKB/TrEMBL
    D3Z3A7
    Related
    ENSMUSP00000122853.2, ENSMUST00000134346.8
    Conserved Domains (3) summary
    smart00765
    Location:69 → 172
    MANEC; The MANEC domain, formerly called MANSC
    smart00089
    Location:191 → 285
    PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
    cd00112
    Location:299 → 333
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

  5. NM_001379152.1 → NP_001366081.1  low-density lipoprotein receptor-related protein 11 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC156391, FO907139
    UniProtKB/TrEMBL
    D3Z3A7
    Conserved Domains (2) summary
    smart00765
    Location:69 → 172
    MANEC; The MANEC domain, formerly called MANSC
    smart00089
    Location:191 → 285
    PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins

  6. NM_172784.4 → NP_766372.1  low-density lipoprotein receptor-related protein 11 isoform 1 precursor

    See identical proteins and their annotated locations for NP_766372.1

    Status: VALIDATED

    Source sequence(s)
    AC156391, FO907139
    Consensus CDS
    CCDS23686.1
    UniProtKB/Swiss-Prot
    Q8C7Y7, Q8CB67
    UniProtKB/TrEMBL
    D3Z3A7
    Related
    ENSMUSP00000019931.6, ENSMUST00000019931.12
    Conserved Domains (3) summary
    smart00765
    Location:69 → 172
    MANEC; The MANEC domain, formerly called MANSC
    smart00089
    Location:191 → 280
    PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
    cd00112
    Location:294 → 328
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    7465532..7501247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155769.1 → XP_036011662.1  low-density lipoprotein receptor-related protein 11 isoform X1

    Conserved Domains (2) summary
    smart00765
    Location:69 → 172
    MANEC; The MANEC domain, formerly called MANSC
    smart00089
    Location:191 → 285
    PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins

  2. XM_036155770.1 → XP_036011663.1  low-density lipoprotein receptor-related protein 11 isoform X2

    Conserved Domains (2) summary
    smart00765
    Location:69 → 172
    MANEC; The MANEC domain, formerly called MANSC
    smart00089
    Location:191 → 280
    PKD; Repeats in polycystic kidney disease 1 (PKD1) and other proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CB67.1 GenPept UniProtKB/Swiss-Prot:Q8CB67

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous