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Pcyt1b phosphate cytidylyltransferase 1, choline, beta isoform [ Mus musculus (house mouse) ]

Gene ID: 236899, updated on 5-Mar-2024

Summary

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Official Symbol
Pcyt1bprovided by MGI
Official Full Name
phosphate cytidylyltransferase 1, choline, beta isoformprovided by MGI
Primary source
MGI:MGI:2147987
See related
Ensembl:ENSMUSG00000035246 AllianceGenome:MGI:2147987
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CTTbeta
Summary
Enables choline-phosphate cytidylyltransferase activity. Involved in CDP-choline pathway. Acts upstream of or within ovarian follicle development and spermatogenesis. Predicted to be located in endoplasmic reticulum. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and sensory organ. Orthologous to human PCYT1B (phosphate cytidylyltransferase 1B, choline). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 9.3), CNS E14 (RPKM 7.0) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X C3; X 41.28 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (92698469..92793557)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (93654863..93749951)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene polymerase (DNA directed), alpha 1 Neighboring gene predicted gene, 23557 Neighboring gene STARR-seq mESC enhancer starr_47550 Neighboring gene STARR-seq mESC enhancer starr_47551 Neighboring gene predicted pseudogene 6985 Neighboring gene predicted gene, 35641 Neighboring gene pyruvate dehydrogenase kinase, isoenzyme 3 Neighboring gene SPT20 SAGA complex component, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets. Ogasawara Y, et al. Nat Commun, 2020 Sep 8. PMID 32900992, Free PMC Article
  2. Involvement of CTP:phosphocholine cytidylyltransferase-β2 in axonal phosphatidylcholine synthesis and branching of neurons. Strakova J, et al. Biochim Biophys Acta, 2011 Oct. PMID 21736954
  3. Characterization of the murine CTP:phosphocholine cytidylyltransferase beta gene promoter. Marcucci H, et al. Biochim Biophys Acta, 2008 May. PMID 18423385
  4. Probucol therapy overcomes the reproductive defect in CTP: phosphocholine cytidylyltransferase beta2 knockout mice. Gunter C, et al. Biochim Biophys Acta, 2007 Jul. PMID 17560827, Free PMC Article
  5. Disruption of CCTbeta2 expression leads to gonadal dysfunction. Jackowski S, et al. Mol Cell Biol, 2004 Jun. PMID 15143167, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long-term autophagy is sustained by activation of CCTbeta3 on lipid droplets.
    Title: Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets.
  2. Results suggest that the activities of alternative promoters provide for greater flexibility in the control of CTP:phosphocholine cytidylyltransferase beta isoform expression.
    Title: Characterization of the murine CTP:phosphocholine cytidylyltransferase beta gene promoter.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables choline-phosphate cytidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline-phosphate cytidylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables choline-phosphate cytidylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-choline pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in CDP-choline pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylcholine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
choline-phosphate cytidylyltransferase B
Names
CCT B
CCT-beta
CT B
CTP:phosphocholine cytidylyltransferase B
phosphorylcholine transferase B
NP_808214.1
NP_997593.1
XP_006528048.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177546.2 → NP_808214.1  choline-phosphate cytidylyltransferase B isoform 2

    See identical proteins and their annotated locations for NP_808214.1

    Status: VALIDATED

    Source sequence(s)
    AK032027, BB642464
    Consensus CDS
    CCDS41061.1
    UniProtKB/Swiss-Prot
    Q811Q9
    Related
    ENSMUSP00000109566.3, ENSMUST00000113933.9
    Conserved Domains (1) summary
    PLN02413
    Location:42 → 263
    PLN02413; choline-phosphate cytidylyltransferase

  2. NM_211138.1 → NP_997593.1  choline-phosphate cytidylyltransferase B isoform 1

    See identical proteins and their annotated locations for NP_997593.1

    Status: VALIDATED

    Source sequence(s)
    AK032027, BB646993
    Consensus CDS
    CCDS30274.1
    UniProtKB/Swiss-Prot
    Q3UEW0, Q80Y63, Q811Q8, Q811Q9, Q8BKD2, Q8C085
    Related
    ENSMUSP00000044280.4, ENSMUST00000045898.4
    Conserved Domains (1) summary
    cl28626
    Location:72 → 314
    PLN02406; ethanolamine-phosphate cytidylyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    92698469..92793557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527985.5 → XP_006528048.1  choline-phosphate cytidylyltransferase B isoform X1

    Conserved Domains (1) summary
    PLN02413
    Location:52 → 294
    PLN02413; choline-phosphate cytidylyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q811Q9.2 GenPept UniProtKB/Swiss-Prot:Q811Q9

Gene LinkOut

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