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Cib3 calcium and integrin binding family member 3 [ Mus musculus (house mouse) ]

Gene ID: 234421, updated on 26-Mar-2024

Summary

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Official Symbol
Cib3provided by MGI
Official Full Name
calcium and integrin binding family member 3provided by MGI
Primary source
MGI:MGI:2685953
See related
Ensembl:ENSMUSG00000074240 AllianceGenome:MGI:2685953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KIP3; Gm1107; C730014M21Rik
Summary
Predicted to enable calcium ion binding activity and magnesium ion binding activity. Is expressed in skeletal muscle. Orthologous to human CIB3 (calcium and integrin binding family member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 34.88 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (72958180..72966892, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (72204335..72213086, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11387 Neighboring gene RAB8A, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E8246 Neighboring gene hematopoietic SH2 domain containing Neighboring gene STARR-positive B cell enhancer ABC_E9026 Neighboring gene family with sequence similarity 32, member A Neighboring gene STARR-positive B cell enhancer ABC_E2266 Neighboring gene predicted gene, 51536 Neighboring gene adaptor-related protein complex AP-1, mu subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CIB2 and CIB3 Regulate Stereocilia Maintenance and Mechanoelectrical Transduction in Mouse Vestibular Hair Cells. Wang X, et al. J Neurosci, 2023 May 3. PMID 37001993, Free PMC Article
  2. Cib2 binds integrin alpha7Bbeta1D and is reduced in laminin alpha2 chain-deficient muscular dystrophy. Häger M, et al. J Biol Chem, 2008 Sep 5. PMID 18611855, Free PMC Article
  3. CIB2 interacts with TMC1 and TMC2 and is essential for mechanotransduction in auditory hair cells. Giese APJ, et al. Nat Commun, 2017 Jun 29. PMID 28663585, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CIB2 and CIB3 Regulate Stereocilia Maintenance and Mechanoelectrical Transduction in Mouse Vestibular Hair Cells.
    Title: CIB2 and CIB3 Regulate Stereocilia Maintenance and Mechanoelectrical Transduction in Mouse Vestibular Hair Cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
calcium and integrin-binding family member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080812.2 → NP_001074281.1  calcium and integrin-binding family member 3 isoform 2

    See identical proteins and their annotated locations for NP_001074281.1

    Status: VALIDATED

    Source sequence(s)
    AC158898
    Consensus CDS
    CCDS52594.1
    UniProtKB/Swiss-Prot
    Q0P523
    Related
    ENSMUSP00000096231.4, ENSMUST00000098630.5
    Conserved Domains (2) summary
    cd00051
    Location:84 → 146
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:81 → 146
    EF-hand_7; EF-hand domain pair

  2. NM_001411781.1 → NP_001398710.1  calcium and integrin-binding family member 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC158898
    UniProtKB/TrEMBL
    A0A5F8MPX9
    Related
    ENSMUSP00000159168.2, ENSMUST00000238973.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    72958180..72966892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0P523.1 GenPept UniProtKB/Swiss-Prot:Q0P523

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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