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SIRT5 sirtuin 5 [ Homo sapiens (human) ]

Gene ID: 23408, updated on 13-Apr-2024

Summary

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Official Symbol
SIRT5provided by HGNC
Official Full Name
sirtuin 5provided by HGNC
Primary source
HGNC:HGNC:14933
See related
Ensembl:ENSG00000124523 MIM:604483; AllianceGenome:HGNC:14933
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2L5
Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in heart (RPKM 3.7), liver (RPKM 2.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6p23
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (13574274..13615158)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (13447831..13488715)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (13574506..13615390)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24036 Neighboring gene ribosomal protein S4X pseudogene 7 Neighboring gene RN7SK pseudogene 204 Neighboring gene uncharacterized LOC105374937 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:13574598-13575184 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:13575185-13575770 Neighboring gene uncharacterized LOC105374938 Neighboring gene uncharacterized LOC124901263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24038 Neighboring gene nucleolar protein 7 Neighboring gene RAN binding protein 9 Neighboring gene U7 small nuclear RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection. Fabbrizi E, et al. Cells, 2023 Mar 9. PMID 36980194, Free PMC Article
  2. Role of SIRT5 in cancer. Friend or Foe? Lagunas-Rangel FA. Biochimie, 2023 Jun. PMID 36813074
  3. SIRT5 reduces the inflammatory response and barrier dysfunction in IL-17A-induced epidermal keratinocytes. Wang C, et al. Allergol Immunopathol (Madr), 2023. PMID 36617819
  4. Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability. Wang HL, et al. Nat Commun, 2022 Oct 17. PMID 36253417, Free PMC Article
  5. SIRT5 is involved in the proliferation and metastasis of breast cancer by promoting aerobic glycolysis. He S, et al. Pathol Res Pract, 2022 Jul. PMID 35576836

See all (125) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SIRT5 promote malignant advancement of chordoma by regulating the desuccinylation of c-myc.
    Title: SIRT5 promote malignant advancement of chordoma by regulating the desuccinylation of c-myc.
  2. SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease.
    Title: SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease.
  3. LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer.
    Title: LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer.
  4. Role of SIRT5 in cancer. Friend or Foe?
    Title: Role of SIRT5 in cancer. Friend or Foe?
  5. The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease.
    Title: The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease.
  6. Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection.
    Title: Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection.
  7. Circ-ATL1 silencing reverses the activation effects of SIRT5 on smooth muscle cellular proliferation, migration and contractility in intracranial aneurysm by adsorbing miR-455.
    Title: Circ-ATL1 silencing reverses the activation effects of SIRT5 on smooth muscle cellular proliferation, migration and contractility in intracranial aneurysm by adsorbing miR-455.
  8. SIRT5 reduces the inflammatory response and barrier dysfunction in IL-17A-induced epidermal keratinocytes.
    Title: SIRT5 reduces the inflammatory response and barrier dysfunction in IL-17A-induced epidermal keratinocytes.
  9. Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability.
    Title: Sirtuin5 protects colorectal cancer from DNA damage by keeping nucleotide availability.
  10. SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.
    Title: SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein.
Submit: New GeneRIF Correction See all GeneRIFs (83)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36950

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables NAD+ binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables NAD+-protein ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
 PubMed 
enables NAD-dependent protein deacetylase activity TAS
Traceable Author Statement
more info
  
enables protein-glutaryllysine deglutarylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-glutaryllysine deglutarylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-malonyllysine demalonylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-malonyllysine demalonylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-succinyllysine desuccinylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-succinyllysine desuccinylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in epigenetic regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization TAS
Traceable Author Statement
more info
  
involved_in negative regulation of cardiac muscle cell apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of reactive oxygen species metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-lysine demalonylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine demalonylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-lysine desuccinylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-lysine desuccinylation IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in protein deacetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deacetylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deglutarylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deglutarylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein demalonylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein desuccinylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of ketone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to nutrient levels IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
NAD-dependent protein deacylase sirtuin-5, mitochondrial
Names
NAD-dependent deacetylase sirtuin-5
NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
silent mating type information regulation 2, S.cerevisiae, homolog 5
sir2-like 5
sirtuin type 5
NP_001180196.1
NP_001229756.1
NP_001363727.1
NP_001363728.1
NP_001363729.1
NP_001363730.1
NP_001363731.1
NP_001363732.1
NP_001363733.1
NP_001363734.1
NP_001363735.1
NP_001363736.1
NP_001363737.1
NP_001363738.1
NP_001363739.1
NP_001363740.1
NP_001363741.1
NP_001363742.1
NP_001363743.1
NP_001363744.1
NP_036373.1
NP_112534.1
XP_016866109.1
XP_016866113.1
XP_024302156.1
XP_047274470.1
XP_047274471.1
XP_047274472.1
XP_047274473.1
XP_047274474.1
XP_047274475.1
XP_047274476.1
XP_047274477.1
XP_047274478.1
XP_047274479.1
XP_047274480.1
XP_047274481.1
XP_047274482.1
XP_047274483.1
XP_054210899.1
XP_054210900.1
XP_054210901.1
XP_054210902.1
XP_054210903.1
XP_054210904.1
XP_054210905.1
XP_054210906.1
XP_054210907.1
XP_054210908.1
XP_054210909.1
XP_054210910.1
XP_054210911.1
XP_054210912.1
XP_054210913.1
XP_054210914.1
XP_054210915.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001193267.2 → NP_001180196.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AK302467, AL441883, BC000126, CB155518
    Consensus CDS
    CCDS54966.1
    UniProtKB/TrEMBL
    A0A7P0T915
    Related
    ENSP00000352830.3, ENST00000359782.8
    Conserved Domains (1) summary
    cd01412
    Location:51 → 283
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...

  2. NM_001242827.1 → NP_001229756.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 4

    See identical proteins and their annotated locations for NP_001229756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' region, resulting in a downstream AUG start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4 and 19 both encode the same isoform (4).
    Source sequence(s)
    AK294162, AL441883, CB155518
    UniProtKB/Swiss-Prot
    Q9NXA8
    Conserved Domains (1) summary
    cl00195
    Location:4 → 193
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  3. NM_001376798.1 → NP_001363727.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1 and 6-14, encodes isoform 1.
    Source sequence(s)
    AL441883
    Consensus CDS
    CCDS4526.1
    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
    UniProtKB/TrEMBL
    A0A7P0T915
    Related
    ENSP00000380509.3, ENST00000397350.7
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  4. NM_001376799.1 → NP_001363728.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 5, and 7-14, encodes isoform 1.
    Source sequence(s)
    AL441883
    Consensus CDS
    CCDS4526.1
    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
    UniProtKB/TrEMBL
    A0A7P0T915
    Related
    ENSP00000505496.1, ENST00000680432.1
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  5. NM_001376800.1 → NP_001363729.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 5, 6, and 8-14, encodes isoform 1.
    Source sequence(s)
    AL441883
    Consensus CDS
    CCDS4526.1
    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
    UniProtKB/TrEMBL
    A0A7P0T915
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  6. NM_001376801.1 → NP_001363730.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 5-7, and 9-14, encodes isoform 1.
    Source sequence(s)
    AL441883
    Consensus CDS
    CCDS4526.1
    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
    UniProtKB/TrEMBL
    A0A7P0T915
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  7. NM_001376802.1 → NP_001363731.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 1, 5-8, and 10-14, encodes isoform 1.
    Source sequence(s)
    AL441883
    Consensus CDS
    CCDS4526.1
    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
    UniProtKB/TrEMBL
    A0A7P0T915
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  8. NM_001376803.1 → NP_001363732.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 1, 5-9, and 11-14, encodes isoform 1.
    Source sequence(s)
    AL441883
    Consensus CDS
    CCDS4526.1
    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
    UniProtKB/TrEMBL
    A0A7P0T915
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  9. NM_001376804.1 → NP_001363733.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 1, 5-10, and 12-14, encodes isoform 1.
    Source sequence(s)
    AL441883
    Consensus CDS
    CCDS4526.1
    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
    UniProtKB/TrEMBL
    A0A7P0T915
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  10. NM_001376805.1 → NP_001363734.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 1, 5-11, 13, and 14, encodes isoform 1.
    Source sequence(s)
    AL441883
    Consensus CDS
    CCDS4526.1
    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
    UniProtKB/TrEMBL
    A0A7P0T915
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  11. NM_001376806.1 → NP_001363735.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 1, 5-12, and 14, encodes isoform 1.
    Source sequence(s)
    AL441883
    Consensus CDS
    CCDS4526.1
    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
    UniProtKB/TrEMBL
    A0A7P0T915
    Related
    ENSP00000505086.1, ENST00000680151.1
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  12. NM_001376807.1 → NP_001363736.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 1 and 5-13, encodes isoform 1.
    Source sequence(s)
    AL441883
    Consensus CDS
    CCDS4526.1
    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
    UniProtKB/TrEMBL
    A0A7P0T915
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  13. NM_001376808.1 → NP_001363737.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AL441883
    Consensus CDS
    CCDS4527.1
    UniProtKB/TrEMBL
    A0A7P0T915
    Related
    ENSP00000505469.1, ENST00000680707.1
    Conserved Domains (1) summary
    cd01412
    Location:51 → 285
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  14. NM_001376809.1 → NP_001363738.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variant 17, encodes isoform 5.
    Source sequence(s)
    AL441883
    Consensus CDS
    CCDS93861.1
    UniProtKB/TrEMBL
    A0A7P0T9N1
    Related
    ENSP00000505415.1, ENST00000681012.1
    Conserved Domains (1) summary
    cl00195
    Location:51 → 183
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  15. NM_001376810.1 → NP_001363739.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 16, encodes isoform 5.
    Source sequence(s)
    AL441883
    Consensus CDS
    CCDS93861.1
    UniProtKB/TrEMBL
    A0A7P0T9N1
    Related
    ENSP00000505733.1, ENST00000680402.1
    Conserved Domains (1) summary
    cl00195
    Location:51 → 183
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  16. NM_001376811.1 → NP_001363740.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL441883
    Conserved Domains (1) summary
    cd01412
    Location:12 → 262
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  17. NM_001376812.1 → NP_001363741.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variant 4, encodes isoform 4.
    Source sequence(s)
    AL441883
    Conserved Domains (1) summary
    cl00195
    Location:4 → 193
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  18. NM_001376813.1 → NP_001363742.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variant 21, encodes isoform 7.
    Source sequence(s)
    AL441883
    Consensus CDS
    CCDS93862.1
    UniProtKB/TrEMBL
    A0A7P0T877, A0A7P0Z4N6
    Related
    ENSP00000506431.1, ENST00000681243.1
    Conserved Domains (1) summary
    cl00195
    Location:51 → 158
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  19. NM_001376814.1 → NP_001363743.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variant 20, encodes isoform 7.
    Source sequence(s)
    AL441883
    Consensus CDS
    CCDS93862.1
    UniProtKB/TrEMBL
    A0A7P0T877, A0A7P0Z4N6
    Conserved Domains (1) summary
    cl00195
    Location:51 → 158
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  20. NM_001376815.1 → NP_001363744.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL441883

  21. NM_012241.5 → NP_036373.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_036373.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 5-14 all encode the same protein.
    Source sequence(s)
    AF083110, AL441883, BC000126, DC314190
    Consensus CDS
    CCDS4526.1
    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
    UniProtKB/TrEMBL
    A0A7P0T915
    Related
    ENSP00000476228.1, ENST00000606117.2
    Conserved Domains (1) summary
    cd01412
    Location:51 → 301
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

  22. NM_031244.3 → NP_112534.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_112534.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR, C-terminal coding region, and 3' UTR as compared to transcript variant 1. This variant encodes isoform 2 which has a distinct and shorter C-terminus than isoform 1. Variants 2 and 15 both encode the same isoform (2).
    Source sequence(s)
    AJ420496, AK000355, CB155518
    Consensus CDS
    CCDS4527.1
    UniProtKB/TrEMBL
    A0A7P0T915
    Related
    ENSP00000368564.4, ENST00000379262.8
    Conserved Domains (1) summary
    cd01412
    Location:51 → 285
    SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

RNA

  1. NR_164852.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL441883

  2. NR_164853.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL441883

  3. NR_164854.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL441883
    Related
    ENST00000379250.10

  4. NR_164856.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL441883
    Related
    ENST00000681905.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    13574274..13615158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418519.1 → XP_047274475.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

  2. XM_047418522.1 → XP_047274478.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

  3. XM_047418520.1 → XP_047274476.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

  4. XM_024446388.2 → XP_024302156.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X6

    UniProtKB/TrEMBL
    A0A7P0TBF5
    Conserved Domains (1) summary
    cl00195
    Location:51 → 183
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  5. XM_017010620.3 → XP_016866109.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A7P0T915
    Related
    ENSP00000505346.1, ENST00000680852.1
    Conserved Domains (1) summary
    cd01412
    Location:51 → 291
    SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...

  6. XM_017010624.3 → XP_016866113.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X5

    UniProtKB/TrEMBL
    A0A7P0TBF5
    Conserved Domains (1) summary
    cl00195
    Location:51 → 183
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

  7. XM_047418515.1 → XP_047274471.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6

  8. XM_047418516.1 → XP_047274472.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6

  9. XM_047418527.1 → XP_047274483.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

    UniProtKB/TrEMBL
    A0A7P0T9N1

  10. XM_047418514.1 → XP_047274470.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6

  11. XM_047418526.1 → XP_047274482.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

    UniProtKB/TrEMBL
    A0A7P0T9N1

  12. XM_047418525.1 → XP_047274481.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

    UniProtKB/TrEMBL
    A0A7P0T9N1

  13. XM_047418518.1 → XP_047274474.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

  14. XM_047418517.1 → XP_047274473.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

  15. XM_047418523.1 → XP_047274479.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

  16. XM_047418524.1 → XP_047274480.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

  17. XM_047418521.1 → XP_047274477.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    13447831..13488715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354928.1 → XP_054210903.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

  2. XM_054354932.1 → XP_054210907.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

  3. XM_054354929.1 → XP_054210904.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

  4. XM_054354935.1 → XP_054210910.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

  5. XM_054354940.1 → XP_054210915.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X6

  6. XM_054354934.1 → XP_054210909.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

  7. XM_054354939.1 → XP_054210914.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X5

  8. XM_054354925.1 → XP_054210900.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6

  9. XM_054354938.1 → XP_054210913.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

    UniProtKB/TrEMBL
    A0A7P0T9N1

  10. XM_054354924.1 → XP_054210899.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6

  11. XM_054354937.1 → XP_054210912.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

    UniProtKB/TrEMBL
    A0A7P0T9N1

  12. XM_054354936.1 → XP_054210911.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

    UniProtKB/TrEMBL
    A0A7P0T9N1

  13. XM_054354930.1 → XP_054210905.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

  14. XM_054354927.1 → XP_054210902.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

  15. XM_054354933.1 → XP_054210908.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

  16. XM_054354931.1 → XP_054210906.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

  17. XM_054354926.1 → XP_054210901.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NXA8.2 GenPept UniProtKB/Swiss-Prot:Q9NXA8

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