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Tnrc6a trinucleotide repeat containing 6a [ Mus musculus (house mouse) ]

Gene ID: 233833, updated on 5-Mar-2024

Summary

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Official Symbol
Tnrc6aprovided by MGI
Official Full Name
trinucleotide repeat containing 6aprovided by MGI
Primary source
MGI:MGI:2385292
See related
Ensembl:ENSMUSG00000052707 AllianceGenome:MGI:2385292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GW182; Tnrc6; CAGH26; 2010321I05Rik; 3110054G10Rik; D130023A07Rik
Summary
This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein is highly similar to a human protein that functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The human protein associates with messenger RNAs and argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies, and inhibiting its expression delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 14.3), CNS E14 (RPKM 13.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F2- F3; 7 67.42 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (122630324..122794519)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (123031101..123195296)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L11 pseudogene Neighboring gene predicted gene, 51498 Neighboring gene VISTA enhancer mm1484 Neighboring gene predicted gene, 39084 Neighboring gene STARR-seq mESC enhancer starr_20085 Neighboring gene STARR-positive B cell enhancer ABC_E11366 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:130281644-130281845 Neighboring gene STARR-seq mESC enhancer starr_20086 Neighboring gene STARR-seq mESC enhancer starr_20088 Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 11 Neighboring gene STARR-seq mESC enhancer starr_20089 Neighboring gene STARR-seq mESC enhancer starr_20090 Neighboring gene Rho GTPase activating protein 17 Neighboring gene STARR-positive B cell enhancer ABC_E4974 Neighboring gene STARR-seq mESC enhancer starr_20097

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. GW bodies, microRNAs and the cell cycle. Lian S, et al. Cell Cycle, 2006 Feb. PMID 16418578
  2. In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA. La Rocca G, et al. Proc Natl Acad Sci U S A, 2015 Jan 20. PMID 25568082, Free PMC Article
  3. miR-30 family microRNAs regulate myogenic differentiation and provide negative feedback on the microRNA pathway. Guess MG, et al. PLoS One, 2015. PMID 25689854, Free PMC Article
  4. RBM19 is essential for preimplantation development in the mouse. Zhang J, et al. BMC Dev Biol, 2008 Dec 16. PMID 19087264, Free PMC Article
  5. GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation. Yang Z, et al. J Cell Sci, 2004 Nov 1. PMID 15494374

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GW182 is an essential functional component in the RNA-induced silencing complex for miRNA-mediated gene silencing in vivo
    Title: Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC11932

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to starvation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within endoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within maintenance of protein location in cell ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in miRNA-mediated gene silencing by inhibition of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA-mediated post-transcriptional gene silencing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in miRNA-mediated post-transcriptional gene silencing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body ISO
Inferred from Sequence Orthology
more info
  
located_in P-body ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of RISC complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
trinucleotide repeat-containing gene 6A protein
Names
GW182 autoantigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144925.3 → NP_659174.3  trinucleotide repeat-containing gene 6A protein

    Status: VALIDATED

    Source sequence(s)
    AC138364, AK147327, BF020619, BY720212, CD802917
    Consensus CDS
    CCDS57583.1
    UniProtKB/Swiss-Prot
    F6ZMJ4, Q3UHK8
    Related
    ENSMUSP00000091595.6, ENSMUST00000094053.7
    Conserved Domains (4) summary
    cd12711
    Location:1715 → 1797
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:1060 → 1185
    Ago_hook; Argonaute hook
    pfam12938
    Location:1266 → 1416
    M_domain; M domain of GW182
    pfam16608
    Location:1439 → 1702
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    122630324..122794519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241757.1 → XP_011240059.1  trinucleotide repeat-containing gene 6A protein isoform X1

    Conserved Domains (4) summary
    cd12711
    Location:1773 → 1855
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:1069 → 1194
    Ago_hook; Argonaute hook
    pfam12938
    Location:1289 → 1474
    M_domain; M domain of GW182
    pfam16608
    Location:1497 → 1760
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

  2. XM_017322202.1 → XP_017177691.1  trinucleotide repeat-containing gene 6A protein isoform X6

    Conserved Domains (4) summary
    cd12711
    Location:1773 → 1855
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:1069 → 1194
    Ago_hook; Argonaute hook
    pfam12938
    Location:1289 → 1474
    M_domain; M domain of GW182
    pfam16608
    Location:1497 → 1760
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

  3. XM_011241760.2 → XP_011240062.1  trinucleotide repeat-containing gene 6A protein isoform X5

    Conserved Domains (4) summary
    cd12711
    Location:1750 → 1832
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:1069 → 1194
    Ago_hook; Argonaute hook
    pfam12938
    Location:1289 → 1378
    M_domain; M domain of GW182
    pfam16608
    Location:1474 → 1737
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

  4. XM_011241762.2 → XP_011240064.1  trinucleotide repeat-containing gene 6A protein isoform X7

    Conserved Domains (4) summary
    cd12711
    Location:1724 → 1806
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:1069 → 1194
    Ago_hook; Argonaute hook
    pfam12938
    Location:1275 → 1425
    M_domain; M domain of GW182
    pfam16608
    Location:1448 → 1711
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

  5. XM_017322203.2 → XP_017177692.1  trinucleotide repeat-containing gene 6A protein isoform X10

    Conserved Domains (4) summary
    cd12711
    Location:1701 → 1783
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:1069 → 1194
    Ago_hook; Argonaute hook
    pfam12938
    Location:1275 → 1329
    M_domain; M domain of GW182
    pfam16608
    Location:1425 → 1688
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

  6. XM_011241758.2 → XP_011240060.1  trinucleotide repeat-containing gene 6A protein isoform X3

    Conserved Domains (4) summary
    cd12711
    Location:1762 → 1844
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:1069 → 1183
    Ago_hook; Argonaute hook
    pfam12938
    Location:1278 → 1463
    M_domain; M domain of GW182
    pfam16608
    Location:1486 → 1749
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

  7. XM_011241763.2 → XP_011240065.1  trinucleotide repeat-containing gene 6A protein isoform X9

    Conserved Domains (4) summary
    cd12711
    Location:1713 → 1795
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:1069 → 1183
    Ago_hook; Argonaute hook
    pfam12938
    Location:1264 → 1414
    M_domain; M domain of GW182
    pfam16608
    Location:1437 → 1700
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

  8. XM_036153008.1 → XP_036008901.1  trinucleotide repeat-containing gene 6A protein isoform X12

    Conserved Domains (5) summary
    pfam10427
    Location:1069 → 1183
    Ago_hook; Argonaute hook
    pfam12938
    Location:1264 → 1318
    M_domain; M domain of GW182
    pfam16608
    Location:1416 → 1677
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
    cd12711
    Location:1685 → 1776
    RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
    NF033849
    Location:596 → 854
    ser_rich_anae_1; serine-rich protein

  9. XM_011241764.2 → XP_011240066.1  trinucleotide repeat-containing gene 6A protein isoform X15

    Conserved Domains (2) summary
    pfam10427
    Location:1069 → 1194
    Ago_hook; Argonaute hook
    pfam12938
    Location:1289 → 1361
    M_domain; M domain of GW182

  10. XM_011241765.3 → XP_011240067.1  trinucleotide repeat-containing gene 6A protein isoform X16

    UniProtKB/TrEMBL
    Q05CE3
    Conserved Domains (1) summary
    pfam10427
    Location:1069 → 1161
    Ago_hook; Argonaute hook

  11. XM_006507705.3 → XP_006507768.1  trinucleotide repeat-containing gene 6A protein isoform X2

    Conserved Domains (4) summary
    cd12711
    Location:1764 → 1846
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:1060 → 1185
    Ago_hook; Argonaute hook
    pfam12938
    Location:1280 → 1465
    M_domain; M domain of GW182
    pfam16608
    Location:1488 → 1751
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

  12. XM_017322204.3 → XP_017177693.1  trinucleotide repeat-containing gene 6A protein isoform X11

    Conserved Domains (4) summary
    cd12711
    Location:1692 → 1774
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:1060 → 1185
    Ago_hook; Argonaute hook
    pfam12938
    Location:1266 → 1320
    M_domain; M domain of GW182
    pfam16608
    Location:1416 → 1679
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

  13. XM_017322201.3 → XP_017177690.1  trinucleotide repeat-containing gene 6A protein isoform X4

    Conserved Domains (4) summary
    cd12711
    Location:1753 → 1835
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:1060 → 1174
    Ago_hook; Argonaute hook
    pfam12938
    Location:1269 → 1454
    M_domain; M domain of GW182
    pfam16608
    Location:1477 → 1740
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

  14. XM_017322205.3 → XP_017177694.1  trinucleotide repeat-containing gene 6A protein isoform X13

    UniProtKB/TrEMBL
    A0A0U1RQ65
    Conserved Domains (4) summary
    cd12711
    Location:1509 → 1591
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:805 → 930
    Ago_hook; Argonaute hook
    pfam12938
    Location:1025 → 1210
    M_domain; M domain of GW182
    pfam16608
    Location:1233 → 1496
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

  15. XM_036153009.1 → XP_036008902.1  trinucleotide repeat-containing gene 6A protein isoform X14

    UniProtKB/TrEMBL
    A0A0U1RQ65
    Conserved Domains (5) summary
    pfam10427
    Location:805 → 930
    Ago_hook; Argonaute hook
    pfam12938
    Location:1011 → 1161
    M_domain; M domain of GW182
    pfam16608
    Location:1186 → 1447
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
    cd12711
    Location:1455 → 1546
    RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
    NF033849
    Location:332 → 590
    ser_rich_anae_1; serine-rich protein

  16. XM_017322206.3 → XP_017177695.1  trinucleotide repeat-containing gene 6A protein isoform X13

    UniProtKB/TrEMBL
    A0A0U1RQ65
    Related
    ENSMUSP00000146266.2, ENSMUST00000205760.2
    Conserved Domains (4) summary
    cd12711
    Location:1509 → 1591
    RRM_TNRC6A; RNA recognition motif in vertebrate GW182 autoantigen
    pfam10427
    Location:805 → 930
    Ago_hook; Argonaute hook
    pfam12938
    Location:1025 → 1210
    M_domain; M domain of GW182
    pfam16608
    Location:1233 → 1496
    TNRC6-PABC_bdg; TNRC6-PABC binding domain

  17. XM_036153010.1 → XP_036008903.1  trinucleotide repeat-containing gene 6A protein isoform X14

    UniProtKB/TrEMBL
    A0A0U1RQ65
    Conserved Domains (5) summary
    pfam10427
    Location:805 → 930
    Ago_hook; Argonaute hook
    pfam12938
    Location:1011 → 1161
    M_domain; M domain of GW182
    pfam16608
    Location:1186 → 1447
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
    cd12711
    Location:1455 → 1546
    RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
    NF033849
    Location:332 → 590
    ser_rich_anae_1; serine-rich protein

  18. XM_036153007.1 → XP_036008900.1  trinucleotide repeat-containing gene 6A protein isoform X8

    Conserved Domains (5) summary
    pfam10427
    Location:1016 → 1141
    Ago_hook; Argonaute hook
    pfam12938
    Location:1236 → 1421
    M_domain; M domain of GW182
    pfam16608
    Location:1446 → 1707
    TNRC6-PABC_bdg; TNRC6-PABC binding domain
    cd12711
    Location:1715 → 1806
    RRM_TNRC6A; RNA recognition motif (RRM) found in vertebrate GW182 autoantigen
    NF033849
    Location:543 → 801
    ser_rich_anae_1; serine-rich protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHK8.2 GenPept UniProtKB/Swiss-Prot:Q3UHK8

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