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Tubgcp5 tubulin, gamma complex component 5 [ Mus musculus (house mouse) ]

Gene ID: 233276, updated on 11-Apr-2024

Summary

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Official Symbol
Tubgcp5provided by MGI
Official Full Name
tubulin, gamma complex component 5provided by MGI
Primary source
MGI:MGI:2178836
See related
Ensembl:ENSMUSG00000033790 AllianceGenome:MGI:2178836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GCP5; mKIAA1899; B130010C12Rik
Summary
Predicted to enable gamma-tubulin binding activity and microtubule binding activity. Predicted to contribute to microtubule minus-end binding activity. Predicted to be involved in meiotic cell cycle; microtubule cytoskeleton organization; and mitotic cell cycle. Predicted to be located in cytosol. Predicted to be part of gamma-tubulin large complex. Predicted to be active in centrosome and equatorial microtubule organizing center. Orthologous to human TUBGCP5 (tubulin gamma complex associated protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 4.1), CNS E11.5 (RPKM 4.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B5; 7 33.42 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (55443873..55481207)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (55794125..55831459)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26482 Neighboring gene STARR-seq mESC enhancer starr_18955 Neighboring gene sialic acid binding Ig-like lectin H Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:63049366-63049475 Neighboring gene STARR-seq mESC enhancer starr_18956 Neighboring gene STARR-positive B cell enhancer mm9_chr7:63113113-63113414 Neighboring gene cytoplasmic FMR1 interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_18959 Neighboring gene peroxiredoxin 3 pseudogene Neighboring gene non imprinted in Prader-Willi/Angelman syndrome 2 homolog (human)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Assembly of gamma-tubulin ring complexes: implications for cell biology and disease. Remy MH, et al. Prog Mol Biol Transl Sci, 2013. PMID 23663981
  2. Gamma-tubulin complexes and their interaction with microtubule-organizing centers. Wiese C, et al. Curr Opin Struct Biol, 1999 Apr. PMID 10322210
  3. Gamma-tubulin complexes: size does matter. Jeng R, et al. Trends Cell Biol, 1999 Sep. PMID 10461186
  4. Microtubule nucleation by γ-tubulin complexes. Kollman JM, et al. Nat Rev Mol Cell Biol, 2011 Oct 12. PMID 21993292, Free PMC Article
  5. Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons. Chai JH, et al. Am J Hum Genet, 2003 Oct. PMID 14508708, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. indentification on mouse chromosome 7C
    Title: Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC38608

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables gamma-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in microtubule nucleation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule nucleation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in equatorial microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of gamma-tubulin ring complex ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gamma-tubulin complex component 5
Names
tubulin, gamma complex associated protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360873.1 → NP_001347802.1  gamma-tubulin complex component 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102298, AC160534, AK152033
    Consensus CDS
    CCDS90246.1
    Related
    ENSMUSP00000146111.2, ENSMUST00000205796.2
    Conserved Domains (1) summary
    pfam04130
    Location:273 → 879
    Spc97_Spc98; Spc97 / Spc98 family

  2. NM_001360874.1 → NP_001347803.1  gamma-tubulin complex component 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC102298, AC160534
    UniProtKB/TrEMBL
    Q8R2X3
    Conserved Domains (1) summary
    pfam04130
    Location:1 → 659
    Spc97_Spc98; Spc97 / Spc98 family

  3. NM_146190.3 → NP_666302.2  gamma-tubulin complex component 5 isoform 1

    See identical proteins and their annotated locations for NP_666302.2

    Status: VALIDATED

    Source sequence(s)
    AC160534, AI608079, AK044887, AK051326, BB859898
    Consensus CDS
    CCDS21314.1
    UniProtKB/Swiss-Prot
    Q3U8X5, Q69Z75, Q8BKN5, Q8BLJ9, Q8C083
    Related
    ENSMUSP00000032627.4, ENSMUST00000032627.5
    Conserved Domains (1) summary
    pfam04130
    Location:273 → 942
    Spc97_Spc98; Spc97 / Spc98 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    55443873..55481207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540835.5 → XP_006540898.2  gamma-tubulin complex component 5 isoform X1

    Conserved Domains (1) summary
    cl37603
    Location:271 → 581
    GCP_N_terminal; Gamma tubulin complex component N-terminal

RNA

  1. XR_882029.4 RNA Sequence

  2. XR_003946456.2 RNA Sequence

    Related
    ENSMUST00000206191.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BKN5.2 GenPept UniProtKB/Swiss-Prot:Q8BKN5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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