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Nccrp1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) [ Mus musculus (house mouse) ]

Gene ID: 233038, updated on 5-Mar-2024

Summary

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Official Symbol
Nccrp1provided by MGI
Official Full Name
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish)provided by MGI
Primary source
MGI:MGI:2685009
See related
Ensembl:ENSMUSG00000047586 AllianceGenome:MGI:2685009
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm163; NCCRP-1; 1190020J12Rik
Summary
Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in positive regulation of cell population proliferation and protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human NCCRP1 (NCCRP1, F-box associated domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 27.2), stomach adult (RPKM 14.5) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 16.83 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28243017..28247168, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28543592..28547748, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cytochrome c, somatic pseudogene Neighboring gene syncollin Neighboring gene predicted gene, 38977 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29342572-29342755 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29342797-29343021 Neighboring gene microRNA 7049 Neighboring gene p21 (RAC1) activated kinase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box only protein 50
Names
NCC receptor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081115.2 → NP_001074584.2  F-box only protein 50

    Status: VALIDATED

    Source sequence(s)
    AC136456
    Consensus CDS
    CCDS39862.2
    UniProtKB/Swiss-Prot
    G3X9C2, Q8BT24
    UniProtKB/TrEMBL
    A0A0A0MQ97
    Related
    ENSMUSP00000159104.2, ENSMUST00000239002.2
    Conserved Domains (1) summary
    pfam04300
    Location:90 → 260
    FBA; F-box associated region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28243017..28247168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242451.2 → XP_030098311.1  F-box only protein 50 isoform X1

    UniProtKB/Swiss-Prot
    G3X9C2, Q8BT24
    UniProtKB/TrEMBL
    A0A0A0MQ97
    Conserved Domains (1) summary
    pfam04300
    Location:90 → 260
    FBA; F-box associated region

  2. XM_030242452.1 → XP_030098312.1  F-box only protein 50 isoform X2

    Conserved Domains (1) summary
    pfam04300
    Location:7 → 131
    FBA; F-box associated region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G3X9C2.2 GenPept UniProtKB/Swiss-Prot:G3X9C2

Gene LinkOut

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