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Fbxo21 F-box protein 21 [ Mus musculus (house mouse) ]

Gene ID: 231670, updated on 5-Mar-2024

Summary

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Official Symbol
Fbxo21provided by MGI
Official Full Name
F-box protein 21provided by MGI
Primary source
MGI:MGI:1924223
See related
Ensembl:ENSMUSG00000032898 AllianceGenome:MGI:1924223
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2810425J22Rik
Summary
Predicted to enable DNA binding activity. Is expressed in nervous system and neural retina. Orthologous to human FBXO21 (F-box protein 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 54.7), whole brain E14.5 (RPKM 49.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 57.73 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (118114835..118148263)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117976770..118010198)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Nos1 exon 2 regulatory region Neighboring gene predicted gene, 30360 Neighboring gene STARR-seq mESC enhancer starr_14186 Neighboring gene STARR-seq mESC enhancer starr_14187 Neighboring gene nitric oxide synthase 1, neuronal Neighboring gene predicted gene, 26995 Neighboring gene STARR-positive B cell enhancer ABC_E4781 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:118486912-118487121 Neighboring gene tescalcin Neighboring gene predicted gene 9754 Neighboring gene F-box and WD-40 domain protein 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ubiquitin E3 ligase FBXO21 regulates cytokine-mediated signaling pathways, but is dispensable for steady-state hematopoiesis. Wittorf KJ, et al. Exp Hematol, 2022 Oct. PMID 35987460
  2. Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response. Yu Z, et al. Elife, 2016 Apr 11. PMID 27063938, Free PMC Article
  3. Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. Del Prete D, et al. J Biol Chem, 2016 Aug 12. PMID 27325702, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
  5. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ubiquitin E3 ligase FBXO21 regulates cytokine-mediated signaling pathways, but is dispensable for steady-state hematopoiesis.
    Title: Ubiquitin E3 ligase FBXO21 regulates cytokine-mediated signaling pathways, but is dispensable for steady-state hematopoiesis.
  2. Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
    Title: Lys29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0875, MGC28066

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
F-box only protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346588.1 → NP_001333517.1  F-box only protein 21 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal in-frame segment and is shorter, compared to isoform 1.
    Source sequence(s)
    AK048131, AK049723, BE954194, BP754360, BY478760
    Consensus CDS
    CCDS84947.1
    UniProtKB/TrEMBL
    A0A0J9YU92
    Related
    ENSMUSP00000035506.8, ENSMUST00000035579.10

  2. NM_145564.4 → NP_663539.1  F-box only protein 21 isoform 1

    See identical proteins and their annotated locations for NP_663539.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK049723, BP754360
    Consensus CDS
    CCDS19607.1
    UniProtKB/Swiss-Prot
    Q8BHA5, Q8CHC6, Q8VDH1
    UniProtKB/TrEMBL
    A0A0J9YU92
    Related
    ENSMUSP00000143873.2, ENSMUST00000202447.4
    Conserved Domains (3) summary
    TIGR02097
    Location:500 → 597
    yccV; hemimethylated DNA binding domain
    pfam12937
    Location:30 → 78
    F-box-like; F-box-like
    pfam13369
    Location:258 → 388
    Transglut_core2; Transglutaminase-like superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    118114835..118148263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VDH1.1 GenPept UniProtKB/Swiss-Prot:Q8VDH1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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