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Slc26a1 solute carrier family 26 (sulfate transporter), member 1 [ Mus musculus (house mouse) ]

Gene ID: 231583, updated on 21-Apr-2024

Summary

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Official Symbol
Slc26a1provided by MGI
Official Full Name
solute carrier family 26 (sulfate transporter), member 1provided by MGI
Primary source
MGI:MGI:2385894
See related
Ensembl:ENSMUSG00000046959 AllianceGenome:MGI:2385894
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sat1
Summary
Enables anion transmembrane transporter activity. Involved in chloride transport. Acts upstream of or within oxalate transport and sulfate transport. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; integumental system; liver; nose; and urinary system. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis. Orthologous to human SLC26A1 (solute carrier family 26 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 59.7), kidney adult (RPKM 58.5) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 53.24 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108817744..108826246, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108669878..108678380, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cyclin G associated kinase Neighboring gene transmembrane protein 175 Neighboring gene diacylglycerol kinase, theta Neighboring gene iduronidase, alpha-L Neighboring gene predicted gene, 42151 Neighboring gene fibroblast growth factor receptor-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Absence of the sulfate transporter SAT-1 has no impact on oxalate handling by mouse intestine and does not cause hyperoxaluria or hyperoxalemia. Whittamore JM, et al. Am J Physiol Gastrointest Liver Physiol, 2019 Jan 1. PMID 30383413, Free PMC Article
  2. Deletion of Slc26a1 and Slc26a7 Delays Enamel Mineralization in Mice. Yin K, et al. Front Physiol, 2017. PMID 28559854, Free PMC Article
  3. Mutations in SLC26A1 Cause Nephrolithiasis. Gee HY, et al. Am J Hum Genet, 2016 Jun 2. PMID 27210743, Free PMC Article
  4. Sat1 is dispensable for active oxalate secretion in mouse duodenum. Ko N, et al. Am J Physiol Cell Physiol, 2012 Jul 1. PMID 22517357, Free PMC Article
  5. Urolithiasis and hepatotoxicity are linked to the anion transporter Sat1 in mice. Dawson PA, et al. J Clin Invest, 2010 Mar. PMID 20160351, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Slc26a1 is not essential for spermatogenesis and male fertility in mice.
    Title: Slc26a1 is not essential for spermatogenesis and male fertility in mice.
  2. that SAT-1 has a major role in oxalate excretion via the intestine
    Title: Absence of the sulfate transporter SAT-1 has no impact on oxalate handling by mouse intestine and does not cause hyperoxaluria or hyperoxalemia.
  3. Slc26a1, Slc26a6 and Slc26a7 are novel participants in the extracellular transport of bicarbonate during enamel maturation.
    Title: SLC26A Gene Family Participate in pH Regulation during Enamel Maturation.
  4. study concludes that a DIDS-sensitive basolateral transporter is involved in mediating oxalate secretion across mouse duodenum, but Sat1 itself is dispensable for this process
    Title: Sat1 is dispensable for active oxalate secretion in mouse duodenum.
  5. Sat1 regulates both oxalate and sulfate homeostasis and may be critical to the development of calcium oxalate urolithiasis and hepatotoxicity.
    Title: Urolithiasis and hepatotoxicity are linked to the anion transporter Sat1 in mice.
  6. first characterization of the structure and regulation of the Sat1 gene encoding a SO(4)(2-)/chloride/oxalate anion transporter
    Title: The mouse sulfate anion transporter gene Sat1 (Slc26a1): cloning, tissue distribution, gene structure, functional characterization, and transcriptional regulation thyroid hormone.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables bicarbonate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxalate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxalate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables secondary active sulfate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables solute:inorganic anion antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sulfate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sulfate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfate:bicarbonate antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfate:bicarbonate antiporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables sulfate:bicarbonate antiporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carboxylic acid transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within chloride transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chloride transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within oxalate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oxalate transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sulfate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfate transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sulfate anion transporter 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310691.1 → NP_001297620.1  sulfate anion transporter 1 isoform 1

    See identical proteins and their annotated locations for NP_001297620.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC161813
    Consensus CDS
    CCDS80355.1
    UniProtKB/TrEMBL
    G5E8U1, Q8R4W9
    Related
    ENSMUSP00000113185.2, ENSMUST00000119270.2
    Conserved Domains (2) summary
    cd07042
    Location:554 → 686
    STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
    TIGR00815
    Location:71 → 702
    sulP; high affinity sulphate transporter 1

  2. NM_001310692.1 → NP_001297621.1  sulfate anion transporter 1 isoform 2

    See identical proteins and their annotated locations for NP_001297621.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC161813
    Consensus CDS
    CCDS19517.1
    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Related
    ENSMUSP00000131282.2, ENSMUST00000163328.8
    Conserved Domains (1) summary
    TIGR00815
    Location:55 → 686
    sulP; high affinity sulphate transporter 1

  3. NM_174870.4 → NP_777359.3  sulfate anion transporter 1 isoform 2

    See identical proteins and their annotated locations for NP_777359.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC161813, AK143528
    Consensus CDS
    CCDS19517.1
    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Related
    ENSMUSP00000051561.8, ENSMUST00000051757.14
    Conserved Domains (1) summary
    TIGR00815
    Location:55 → 686
    sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    108817744..108826246 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254412.1 → XP_030110272.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55 → 686
    sulP; high affinity sulphate transporter 1

  2. XM_017320856.2 → XP_017176345.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55 → 686
    sulP; high affinity sulphate transporter 1

  3. XM_036165081.1 → XP_036020974.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55 → 686
    sulP; high affinity sulphate transporter 1

  4. XM_030254414.1 → XP_030110274.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55 → 686
    sulP; high affinity sulphate transporter 1

  5. XM_030254411.1 → XP_030110271.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55 → 686
    sulP; high affinity sulphate transporter 1

  6. XM_017320855.2 → XP_017176344.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55 → 686
    sulP; high affinity sulphate transporter 1

  7. XM_030254413.2 → XP_030110273.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55 → 686
    sulP; high affinity sulphate transporter 1

  8. XM_036165082.1 → XP_036020975.1  sulfate anion transporter 1 isoform X1

    UniProtKB/Swiss-Prot
    P58735, Q80WF6
    UniProtKB/TrEMBL
    Q3UPH6, Q8R4W9
    Conserved Domains (1) summary
    TIGR00815
    Location:55 → 686
    sulP; high affinity sulphate transporter 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58735.1 GenPept UniProtKB/Swiss-Prot:P58735

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