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Lrrc66 leucine rich repeat containing 66 [ Mus musculus (house mouse) ]

Gene ID: 231296, updated on 5-Mar-2024

Summary

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Official Symbol
Lrrc66provided by MGI
Official Full Name
leucine rich repeat containing 66provided by MGI
Primary source
MGI:MGI:2387634
See related
Ensembl:ENSMUSG00000067206 AllianceGenome:MGI:2387634
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Orthologous to human LRRC66 (leucine rich repeat containing 66). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 5.9), colon adult (RPKM 5.2) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C3.3; 5 38.89 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (73763985..73789771, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (73606642..73632421, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E153 Neighboring gene defective in cullin neddylation 1 domain containing 4 Neighboring gene sarcoglycan, beta (dystrophin-associated glycoprotein) Neighboring gene predicted gene, 34902 Neighboring gene spermatogenesis associated 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC38937

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 66

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153568.2 → NP_705796.1  leucine-rich repeat-containing protein 66 precursor

    See identical proteins and their annotated locations for NP_705796.1

    Status: VALIDATED

    Source sequence(s)
    AC140429
    Consensus CDS
    CCDS19343.1
    UniProtKB/Swiss-Prot
    Q8K0B3
    Related
    ENSMUSP00000084423.3, ENSMUST00000087177.4
    Conserved Domains (3) summary
    COG4886
    Location:95 → 326
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:104 → 142
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:165 → 224
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    73763985..73789771 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503952.5 → XP_006504015.1  leucine-rich repeat-containing protein 66 isoform X1

    See identical proteins and their annotated locations for XP_006504015.1

    UniProtKB/Swiss-Prot
    Q8K0B3
    Conserved Domains (3) summary
    COG4886
    Location:95 → 326
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:104 → 142
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:165 → 224
    LRR_8; Leucine rich repeat

  2. XM_006503953.3 → XP_006504016.1  leucine-rich repeat-containing protein 66 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K0B3.1 GenPept UniProtKB/Swiss-Prot:Q8K0B3

Gene LinkOut

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