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Slc35a3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3 [ Mus musculus (house mouse) ]

Gene ID: 229782, updated on 3-Apr-2024

Summary

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Official Symbol
Slc35a3provided by MGI
Official Full Name
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3provided by MGI
Primary source
MGI:MGI:1917648
See related
Ensembl:ENSMUSG00000027957 AllianceGenome:MGI:1917648
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310050P13Rik
Summary
Predicted to enable UDP-galactose transmembrane transporter activity. Predicted to be involved in UDP-N-acetylglucosamine transmembrane transport. Predicted to act upstream of or within carbohydrate transport. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be integral component of Golgi membrane. Is expressed in several structures, including metanephros and testis. Orthologous to human SLC35A3 (solute carrier family 35 member A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 5.1), colon adult (RPKM 4.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc35a3 in Genome Data Viewer
Location:
3 G1; 3 50.44 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (116463118..116506366, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (116669469..116712708, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene SAS-6 centriolar assembly protein Neighboring gene STARR-seq mESC enhancer starr_08785 Neighboring gene major facilitator superfamily domain containing 14A Neighboring gene STARR-positive B cell enhancer ABC_E3464 Neighboring gene STARR-seq mESC enhancer starr_08789 Neighboring gene STARR-seq mESC enhancer starr_08790 Neighboring gene microRNA 3473h Neighboring gene predicted gene, 40126 Neighboring gene predicted gene, 54181 Neighboring gene STARR-seq mESC enhancer starr_08794 Neighboring gene amylo-1,6-glucosidase, 4-alpha-glucanotransferase Neighboring gene STARR-positive B cell enhancer ABC_E4582 Neighboring gene predicted gene, 40128

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Conserved Glu-47 and Lys-50 residues are critical for UDP-N-acetylglucosamine/UMP antiport activity of the mouse Golgi-associated transporter Slc35a3. Toscanini MA, et al. J Biol Chem, 2019 Jun 28. PMID 31118275, Free PMC Article
  2. Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis. Saito S, et al. PLoS One, 2023. PMID 37053259, Free PMC Article
  3. Altered expression of genes involved in regulation of vitamin A metabolism, solute transportation, and cytoskeletal function in the androgen-insensitive tfm mouse testis. O'Shaughnessy PJ, et al. Endocrinology, 2007 Jun. PMID 17332066
  4. Dynamic Expression of Genes Involved in Proteoglycan/Glycosaminoglycan Metabolism during Skin Development. Uijtdewilligen PJE, et al. Biomed Res Int, 2018. PMID 30228991, Free PMC Article
  5. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis.
    Title: Mice lacking nucleotide sugar transporter SLC35A3 exhibit lethal chondrodysplasia with vertebral anomalies and impaired glycosaminoglycan biosynthesis.
  2. cells expressing E47C or K50C mSlc35a3 variants had lower levels of GlcNAc-containing glycoconjugates than WT cells
    Title: Conserved Glu-47 and Lys-50 residues are critical for UDP-N-acetylglucosamine/UMP antiport activity of the mouse Golgi-associated transporter Slc35a3.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC36317

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-galactose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-galactose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables pyrimidine nucleotide-sugar transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in UDP-N-acetylglucosamine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in UDP-galactose transmembrane import into Golgi lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within carbohydrate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide-sugar transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-N-acetylglucosamine transporter
Names
golgi UDP-GlcNAc transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362374.2 → NP_001349303.1  UDP-N-acetylglucosamine transporter isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131038, AC147242
    Consensus CDS
    CCDS17791.1
    UniProtKB/Swiss-Prot
    Q8BRW7, Q8R1T4
    UniProtKB/TrEMBL
    Q3TTK5
    Related
    ENSMUSP00000112674.2, ENSMUST00000120120.8
    Conserved Domains (1) summary
    pfam04142
    Location:1 → 314
    Nuc_sug_transp; Nucleotide-sugar transporter

  2. NM_001404697.1 → NP_001391626.1  UDP-N-acetylglucosamine transporter isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC131038, AC147242

  3. NM_001404698.1 → NP_001391627.1  UDP-N-acetylglucosamine transporter isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC131038, AC147242
    UniProtKB/Swiss-Prot
    Q8BRW7, Q8R1T4

  4. NM_001404699.1 → NP_001391628.1  UDP-N-acetylglucosamine transporter isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC131038, AC147242

  5. NM_001404700.1 → NP_001391629.1  UDP-N-acetylglucosamine transporter isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC131038, AC147242

  6. NM_001404701.1 → NP_001391630.1  UDP-N-acetylglucosamine transporter isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC131038, AC147242

  7. NM_001404702.1 → NP_001391631.1  UDP-N-acetylglucosamine transporter isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC131038, AC147242

  8. NM_001404703.1 → NP_001391632.1  UDP-N-acetylglucosamine transporter isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC131038, AC147242

  9. NM_001404704.1 → NP_001391633.1  UDP-N-acetylglucosamine transporter isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC131038, AC147242

  10. NM_144902.5 → NP_659151.1  UDP-N-acetylglucosamine transporter isoform 1

    See identical proteins and their annotated locations for NP_659151.1

    Status: VALIDATED

    Source sequence(s)
    AC131038, AC147242
    Consensus CDS
    CCDS17791.1
    UniProtKB/Swiss-Prot
    Q8BRW7, Q8R1T4
    UniProtKB/TrEMBL
    Q3TTK5
    Related
    ENSMUSP00000029569.3, ENSMUST00000029569.9
    Conserved Domains (1) summary
    pfam04142
    Location:1 → 314
    Nuc_sug_transp; Nucleotide-sugar transporter

RNA

  1. NR_175853.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131038, AC147242

  2. NR_175854.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC131038, AC147242

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    116463118..116506366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163085.1 → XP_036018978.1  UDP-N-acetylglucosamine transporter isoform X5

    Conserved Domains (1) summary
    pfam04142
    Location:1 → 233
    Nuc_sug_transp; Nucleotide-sugar transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1T4.1 GenPept UniProtKB/Swiss-Prot:Q8R1T4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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