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UBOX5 U-box domain containing 5 [ Homo sapiens (human) ]

Gene ID: 22888, updated on 5-Mar-2024

Summary

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Official Symbol
UBOX5provided by HGNC
Official Full Name
U-box domain containing 5provided by HGNC
Primary source
HGNC:HGNC:17777
See related
Ensembl:ENSG00000185019 MIM:619675; AllianceGenome:HGNC:17777
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UIP5; RNF37; hUIP5; UBCE7IP5
Summary
This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 enzymes and may play a role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Expression
Ubiquitous expression in testis (RPKM 3.8), ovary (RPKM 3.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
20p13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (3107573..3159865, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (3138473..3190765, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3088219..3140511, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:3073228-3073728 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:3073729-3074229 Neighboring gene arginine vasopressin Neighboring gene RNA, 7SL, cytoplasmic 555, pseudogene Neighboring gene UBOX5 antisense RNA 1 Neighboring gene FAST kinase domains 5 Neighboring gene leucine zipper tumor suppressor family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12614 Neighboring gene uncharacterized LOC107985414

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ancient origin of animal U-box ubiquitin ligases. Marín I. BMC Evol Biol, 2010 Oct 27. PMID 20979629, Free PMC Article
  2. Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes. Pringa E, et al. J Biol Chem, 2001 Jun 1. PMID 11274149
  3. A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4. Martinez-Noel G, et al. FEBS Lett, 1999 Jul 9. PMID 10431818
  4. U box proteins as a new family of ubiquitin-protein ligases. Hatakeyama S, et al. J Biol Chem, 2001 Aug 31. PMID 11435423
  5. Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones. Hatakeyama S, et al. Genes Cells, 2004 Jun. PMID 15189447

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0860

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-ubiquitin ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-ubiquitin ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in focal adhesion IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
RING finger protein 37
Names
RING-type E3 ubiquitin transferase RNF37
U-box domain-containing protein 5
ubcM4-interacting protein 5
ubiquitin conjugating enzyme 7 interacting protein 5
NP_001254513.1
NP_055763.1
NP_955447.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267584.2 → NP_001254513.1  RING finger protein 37 isoform c

    See identical proteins and their annotated locations for NP_001254513.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1, which results in a translational frameshift, compared to variant 1. The resulting isoform (c) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL121891, BC064544, BM992259, DA101925
    UniProtKB/TrEMBL
    Q53GQ5
    Conserved Domains (1) summary
    pfam04564
    Location:259 → 337
    U-box; U-box domain

  2. NM_014948.4 → NP_055763.1  RING finger protein 37 isoform a

    See identical proteins and their annotated locations for NP_055763.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AB020667, AL121891, BM992259
    Consensus CDS
    CCDS13046.1
    UniProtKB/Swiss-Prot
    O94941, Q6IAR5, Q86X87, Q9H4J2
    UniProtKB/TrEMBL
    Q53GQ5
    Related
    ENSP00000217173.2, ENST00000217173.7
    Conserved Domains (2) summary
    cd16537
    Location:482 → 528
    RING-HC_RNF37; RING finger, HC subclass, found in RING finger protein 37 (RNF37)
    cd16660
    Location:260 → 312
    RING-Ubox_RNF37; U-box domain, a modified RING finger, found in RING finger protein 37 (RNF37)

  3. NM_199415.3 → NP_955447.1  RING finger protein 37 isoform b

    See identical proteins and their annotated locations for NP_955447.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AL121891, BC046122, BM992259
    Consensus CDS
    CCDS13047.1
    UniProtKB/TrEMBL
    Q53HL0
    Related
    ENSP00000311726.3, ENST00000348031.6
    Conserved Domains (2) summary
    pfam04564
    Location:259 → 337
    U-box; U-box domain
    pfam14634
    Location:432 → 475
    zf-RING_5; zinc-RING finger domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    3107573..3159865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    3138473..3190765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O94941.1 GenPept UniProtKB/Swiss-Prot:O94941

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