Fads2b fatty acid desaturase 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fads2bprovided by MGI
Official Full Name: fatty acid desaturase 2Bprovided by MGI
Primary source: MGI:MGI:2687041
See related: Ensembl:ENSMUSG00000075217 AllianceGenome:MGI:2687041
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm113; Fads2p1; 4833423E24Rik
Summary: Predicted to enable oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in jaw; olfactory epithelium; and submandibular gland primordium. Orthologous to human FADS2B (fatty acid desaturase 2B, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 4.0), ovary adult (RPKM 3.7) and 4 other tissues See more
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Genomic context

Location:: 2 D; 2 49.68 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (85314436..85349279, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (85484092..85518935, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:487710

NoName (e-PCR)
- UniSTS:234447

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fatty acid desaturase 2-like protein FADS2B

Names: fatty acid desaturase 2-like protein FADS2P1; fatty acid desaturase 2B, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081664.2 → NP_001075133.1 fatty acid desaturase 2-like protein FADS2B

See identical proteins and their annotated locations for NP_001075133.1

Status: PROVISIONAL

Source sequence(s)

BC120879

Consensus CDS

CCDS38168.1

UniProtKB/Swiss-Prot

Q0VAX3

Related

ENSMUSP00000097507.2, ENSMUST00000099923.2

Conserved Domains (3) summary

cd03506
Location:206 → 456

Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...

pfam00173
Location:64 → 138

Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

pfam00487
Location:201 → 459

FA_desaturase; Fatty acid desaturase