Slc30a3 solute carrier family 30 (zinc transporter), member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc30a3provided by MGI
Official Full Name: solute carrier family 30 (zinc transporter), member 3provided by MGI
Primary source: MGI:MGI:1345280
See related: Ensembl:ENSMUSG00000029151 AllianceGenome:MGI:1345280
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Znt3
Summary: Predicted to enable zinc ion transmembrane transporter activity. Involved in zinc ion import into synaptic vesicle. Acts upstream of or within positive regulation of transport. Located in hippocampal mossy fiber and synaptic vesicle membrane. Is active in glutamatergic synapse and hippocampal mossy fiber to CA3 synapse. Is integral component of synaptic vesicle membrane. Is expressed in several structures, including brain; metanephros; olfactory nerve; and spinal cord mantle layer. Orthologous to human SLC30A3 (solute carrier family 30 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 97.3), cortex adult (RPKM 39.8) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B1; 5 16.97 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (31243450..31265576, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (31086106..31108244, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of social defeat stress and fluoxetine treatment on neurogenesis and behavior in mice that lack zinc transporter 3 (ZnT3) and vesicular zinc.
Title: Effects of social defeat stress and fluoxetine treatment on neurogenesis and behavior in mice that lack zinc transporter 3 (ZnT3) and vesicular zinc.
Zinc transporter 3 modulates cell proliferation and neuronal differentiation in the adult hippocampus.
Title: Zinc transporter 3 modulates cell proliferation and neuronal differentiation in the adult hippocampus.
Elevated zinc transporter ZnT3 in the dentate gyrus of mast cell-deficient mice.
Title: Elevated zinc transporter ZnT3 in the dentate gyrus of mast cell-deficient mice.
Effects of enriched housing on the neuronal morphology of mice that lack zinc transporter 3 (ZnT3) and vesicular zinc.
Title: Effects of enriched housing on the neuronal morphology of mice that lack zinc transporter 3 (ZnT3) and vesicular zinc.
Zinc Transporter-3 Knockout Mice Demonstrate Age-Dependent Alterations in the Metalloproteome.
Title: Zinc Transporter-3 Knockout Mice Demonstrate Age-Dependent Alterations in the Metalloproteome.
RNA-seq analysis showed a marked decrease in baseline levels of Slc30a3 mRNA in Mcoln1(-/-) mice.
Title: ZnT3 expression levels are down-regulated in the brain of Mcoln1 knockout mice.
ZnT3-/- mice showed reduced colchicine-induced dentate granule cell death.
Title: ZnT3 Gene Deletion Reduces Colchicine-Induced Dentate Granule Cell Degeneration.
the ZnT3 null state removed synaptic zinc, it rather increased free zinc in the cytosol of brain cells, which appeared to increase MMP-9 activity and BDNF levels. The present results suggest that zinc dyshomeostasis during the critical period of brain development may be a possible contributing mechanism for ASD.
Title: Autism phenotypes in ZnT3 null mice: Involvement of zinc dyshomeostasis, MMP-9 activation and BDNF upregulation.
Study showed a behavioral phenotype specifically for female ZnT3 knockout (KO) mice. Comparing results to previous studies, it appears that there may be sex-specific effects of eliminating ZnT3. Female ZnT3 KO mice exhibit abnormalities in locomotion and at skilled motor learning, but study was unable to detect spatial or fear learning deficits previously described in male ZnT3 KO mice.
Title: Behavioral characterization of female zinc transporter 3 (ZnT3) knockout mice.
Regarding rs11126936, the serum zinc concentration was lower in CC homozygotes (0.75 +/- 0.31 mg/L) than in A carriers (0.89 +/- 0.28 mg/L, P = .016).
Title: SLC30A3 and SEP15 gene polymorphisms influence the serum concentrations of zinc and selenium in mature adults.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc30a3 (e-PCR), detects polymorphism
- UniSTS:166295

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables zinc ion transmembrane transporter activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in detoxification of zinc ion	TAS Traceable Author Statement more info	PubMed
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in sequestering of zinc ion	TAS Traceable Author Statement more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion import into lysosome	ISO Inferred from Sequence Orthology more info
involved_in zinc ion import into synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
involved_in zinc ion import into synaptic vesicle	IEP Inferred from Expression Pattern more info	PubMed
involved_in zinc ion import into synaptic vesicle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within zinc ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in hippocampal mossy fiber	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microvesicle	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in synaptic vesicle membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in synaptic vesicle membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: probable proton-coupled zinc antiporter SLC30A3

Names: solute carrier family 30 member 3; zinc transporter 3; znT-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347323.2 → NP_001334252.1 probable proton-coupled zinc antiporter SLC30A3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC109608

Consensus CDS

CCDS84861.1

UniProtKB/TrEMBL

Q3UN07, Q6NZC3, S4R169

Related

ENSMUSP00000144566.2, ENSMUST00000202740.4

Conserved Domains (1) summary

TIGR01297
Location:36 → 323

CDF; cation diffusion facilitator family transporter
NM_001425462.1 → NP_001412391.1 probable proton-coupled zinc antiporter SLC30A3 isoform 2

Status: VALIDATED

Source sequence(s)

AC109608

UniProtKB/TrEMBL

S4R169
NM_001425463.1 → NP_001412392.1 probable proton-coupled zinc antiporter SLC30A3 isoform 2

Status: VALIDATED

Source sequence(s)

AC109608

UniProtKB/TrEMBL

S4R169
NM_001425464.1 → NP_001412393.1 probable proton-coupled zinc antiporter SLC30A3 isoform 2

Status: VALIDATED

Source sequence(s)

AC109608

UniProtKB/TrEMBL

S4R169
NM_011773.4 → NP_035903.2 probable proton-coupled zinc antiporter SLC30A3 isoform 1

See identical proteins and their annotated locations for NP_035903.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC109608

Consensus CDS

CCDS51455.1

UniProtKB/Swiss-Prot

P97441, P97511

UniProtKB/TrEMBL

Q3TMQ7, Q3UN07, Q6NZC3

Related

ENSMUSP00000031037.8, ENSMUST00000031037.14

Conserved Domains (2) summary

TIGR01297
Location:85 → 372

CDF; cation diffusion facilitator family transporter

pfam01545
Location:85 → 293

Cation_efflux; Cation efflux family