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Ikzf1 IKAROS family zinc finger 1 [ Mus musculus (house mouse) ]

Gene ID: 22778, updated on 23-Apr-2024

Summary

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Official Symbol
Ikzf1provided by MGI
Official Full Name
IKAROS family zinc finger 1provided by MGI
Primary source
MGI:MGI:1342540
See related
Ensembl:ENSMUSG00000018654 AllianceGenome:MGI:1342540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LyF-1; hlk-1; Ikaros; Zfpn1a1; Znfn1a1; mKIAA4227; 5832432G11Rik
Summary
The protein encoded by this gene belongs to a family of transcription factors that are characterized by a set of four DNA-binding zinc fingers at the N-terminus and two C-terminal zinc fingers involved in protein dimerization. It is regulated by both epigenetic and transcription factors. This protein is a transcriptional regulator of hematopoietic cell development and homeostasis. In addition, it is required to confer temporal competence to retinal progenitor cells during embryogenesis, demonstrating an essential function in nervous system development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Expression
Biased expression in thymus adult (RPKM 67.8), spleen adult (RPKM 38.3) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A1; 11 7.02 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (11634970..11722930)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (11684962..11772930)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2348 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11464295-11464600 Neighboring gene STARR-seq mESC enhancer starr_28596 Neighboring gene predicted gene, 29945 Neighboring gene predicted gene 11998 Neighboring gene RIKEN cDNA 4930512M02 gene Neighboring gene STARR-seq mESC enhancer starr_28597 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11557248-11557441 Neighboring gene predicted gene 11999 Neighboring gene STARR-positive B cell enhancer mm9_chr11:11590032-11590333 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11611793-11612034 Neighboring gene STARR-positive B cell enhancer ABC_E5207 Neighboring gene predicted gene 12000 Neighboring gene STARR-positive B cell enhancer ABC_E3931 Neighboring gene STARR-positive B cell enhancer mm9_chr11:11666148-11666448 Neighboring gene STARR-positive B cell enhancer ABC_E6952 Neighboring gene STARR-seq mESC enhancer starr_28598 Neighboring gene fidgetin-like 1 Neighboring gene STARR-seq mESC enhancer starr_28601 Neighboring gene STARR-seq mESC enhancer starr_28602 Neighboring gene dopa decarboxylase Neighboring gene predicted gene, 51937

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration. Ballasch I, et al. Brain Behav Immun, 2023 Mar. PMID 36702234
  2. IKAROS is required for the measured response of NOTCH target genes upon external NOTCH signaling. Lemarié M, et al. PLoS Genet, 2021 Mar. PMID 33770102, Free PMC Article
  3. A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice. Boast B, et al. J Immunol, 2021 Apr 1. PMID 33658297, Free PMC Article
  4. An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis. Harman CCD, et al. Proc Natl Acad Sci U S A, 2021 Jan 19. PMID 33446502, Free PMC Article
  5. Integration of high-throughput reporter assays identify a critical enhancer of the Ikzf1 gene. Alomairi J, et al. PLoS One, 2020. PMID 32453736, Free PMC Article

See all (239) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ikaros is a principal regulator of Aire[+] mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.
    Title: Ikaros is a principal regulator of Aire(+) mTEC homeostasis, thymic mimetic cell diversity, and central tolerance.
  2. Impaired tissue homing by the Ikzf3[N159S] variant is mediated by interfering with Ikaros function.
    Title: Impaired tissue homing by the Ikzf3(N159S) variant is mediated by interfering with Ikaros function.
  3. Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration.
    Title: Ikzf1 as a novel regulator of microglial homeostasis in inflammation and neurodegeneration.
  4. Myeloid Ikaros-SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver.
    Title: Myeloid Ikaros-SIRT1 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed mouse and human liver.
  5. A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice.
    Title: A Point Mutation in IKAROS ZF1 Causes a B Cell Deficiency in Mice.
  6. An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis.
    Title: An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis.
  7. Tumor Arrests DN2 to DN3 Pro T Cell Transition and Promotes Its Conversion to Thymic Dendritic Cells by Reciprocally Regulating Notch1 and Ikaros Signaling.
    Title: Tumor Arrests DN2 to DN3 Pro T Cell Transition and Promotes Its Conversion to Thymic Dendritic Cells by Reciprocally Regulating Notch1 and Ikaros Signaling.
  8. deletion of the E120 enhancer resulted in a significant reduction of Ikzf1 mRNA. However, the epigenetic landscape and 3D topology of the locus were only slightly affected, highlighting the complexity of the regulatory landscape regulating the Ikzf1 locus.
    Title: Integration of high-throughput reporter assays identify a critical enhancer of the Ikzf1 gene.
  9. Ikaros and Ikaros-induced enhancers are responsible for the cessation of proliferation and induction of T-cell differentiation in T-ALL cells
    Title: Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity.
  10. altered Ikaros expression in chronic lymphocytic leukemia or radioresistant B-1 cells could determine a responsive status of BCR to self-antigens, which would culminate in the clonal expansion of B-1 cells.
    Title: Deregulation of Ikaros expression in B-1 cells: New insights in the malignant transformation to chronic lymphocytic leukemia.
Submit: New GeneRIF Correction See all GeneRIFs (100)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4227

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables poly-pyrimidine tract binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within Peyer's patch development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within T cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within amacrine cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lymph node development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lymphocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of RNA polymerase II transcription preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neutrophil differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription elongation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retinal bipolar neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within thymus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of pericentric heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of pericentric heterochromatin ISO
Inferred from Sequence Orthology
more info
  
part_of protein-DNA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of transcription regulator complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding protein Ikaros
Names
ikaros family zinc finger protein 1
lymphoid transcription factor LyF-1
zinc finger protein, subfamily 1A, 1 (Ikaros)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025597.3 → NP_001020768.1  DNA-binding protein Ikaros isoform 1

    See identical proteins and their annotated locations for NP_001020768.1

    Status: REVIEWED

    Source sequence(s)
    AL596450
    Consensus CDS
    CCDS24436.1
    UniProtKB/TrEMBL
    G5E8H3, Q571F4
    Related
    ENSMUSP00000075992.5, ENSMUST00000076700.11
    Conserved Domains (2) summary
    sd00017
    Location:119 → 139
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:132 → 156
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001301863.2 → NP_001288792.1  DNA-binding protein Ikaros isoform 1

    See identical proteins and their annotated locations for NP_001288792.1

    Status: REVIEWED

    Source sequence(s)
    AL596450
    Consensus CDS
    CCDS24436.1
    UniProtKB/TrEMBL
    G5E8H3, Q571F4
    Related
    ENSMUSP00000159473.1, ENSMUST00000240540.1
    Conserved Domains (2) summary
    sd00017
    Location:119 → 139
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:132 → 156
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001301865.2 → NP_001288794.1  DNA-binding protein Ikaros isoform 2

    See identical proteins and their annotated locations for NP_001288794.1

    Status: REVIEWED

    Source sequence(s)
    AL596450
    Consensus CDS
    CCDS24437.1
    UniProtKB/Swiss-Prot
    Q03267, Q64044, Q64045, Q64051
    UniProtKB/TrEMBL
    Q5SWU0
    Conserved Domains (2) summary
    COG5048
    Location:1 → 131
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:60 → 80
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001301866.2 → NP_001288795.1  DNA-binding protein Ikaros isoform 3

    See identical proteins and their annotated locations for NP_001288795.1

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    Q3UQ33, Q5GGW5
    Related
    ENSMUSP00000159476.1, ENSMUST00000240543.1
    Conserved Domains (4) summary
    COG5048
    Location:1 → 112
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:60 → 80
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:58 → 80
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:72 → 97
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001301868.2 → NP_001288797.1  DNA-binding protein Ikaros isoform 4

    See identical proteins and their annotated locations for NP_001288797.1

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    Q571F4
    Conserved Domains (3) summary
    COG5048
    Location:143 → 481
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:119 → 139
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:132 → 156
    zf-H2C2_2; Zinc-finger double domain

  6. NM_001404490.1 → NP_001391419.1  DNA-binding protein Ikaros isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL596450

  7. NM_001404491.1 → NP_001391420.1  DNA-binding protein Ikaros isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL596450

  8. NM_001404492.1 → NP_001391421.1  DNA-binding protein Ikaros isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    Q5SWT9

  9. NM_001404493.1 → NP_001391422.1  DNA-binding protein Ikaros isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    Q5SWT9
    Related
    ENSMUSP00000067372.6, ENSMUST00000065433.12

  10. NM_001404494.1 → NP_001391423.1  DNA-binding protein Ikaros isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    Q5SWT9

  11. NM_001404495.1 → NP_001391424.1  DNA-binding protein Ikaros isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL596450

  12. NM_001404496.1 → NP_001391425.1  DNA-binding protein Ikaros isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL596450

  13. NM_001404497.1 → NP_001391426.1  DNA-binding protein Ikaros isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL596450

  14. NM_001404498.1 → NP_001391427.1  DNA-binding protein Ikaros isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    G5E8H3

  15. NM_001404499.1 → NP_001391428.1  DNA-binding protein Ikaros isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    G5E8H3

  16. NM_001404500.1 → NP_001391429.1  DNA-binding protein Ikaros isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    G5E8H3

  17. NM_001404501.1 → NP_001391430.1  DNA-binding protein Ikaros isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    G5E8H3

  18. NM_001404502.1 → NP_001391431.1  DNA-binding protein Ikaros isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    G5E8H3

  19. NM_001404503.1 → NP_001391432.1  DNA-binding protein Ikaros isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    G5E8H3

  20. NM_001404504.1 → NP_001391433.1  DNA-binding protein Ikaros isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    G5E8H3

  21. NM_001404505.1 → NP_001391434.1  DNA-binding protein Ikaros isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    G5E8H3

  22. NM_001404506.1 → NP_001391435.1  DNA-binding protein Ikaros isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    G5E8H3

  23. NM_001404507.1 → NP_001391436.1  DNA-binding protein Ikaros isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL596450

  24. NM_001404508.1 → NP_001391437.1  DNA-binding protein Ikaros isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL596450

  25. NM_001404509.1 → NP_001391438.1  DNA-binding protein Ikaros isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL596450

  26. NM_001404510.1 → NP_001391439.1  DNA-binding protein Ikaros isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL596450

  27. NM_001404511.1 → NP_001391440.1  DNA-binding protein Ikaros isoform 32

    Status: REVIEWED

    Source sequence(s)
    AL596450

  28. NM_001404512.1 → NP_001391441.1  DNA-binding protein Ikaros isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL596450

  29. NM_001404513.1 → NP_001391442.1  DNA-binding protein Ikaros isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL596450

  30. NM_001404514.1 → NP_001391443.1  DNA-binding protein Ikaros isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL596450

  31. NM_001404515.1 → NP_001391444.1  DNA-binding protein Ikaros isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL596450

  32. NM_001404516.1 → NP_001391445.1  DNA-binding protein Ikaros isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL596450

  33. NM_001404517.1 → NP_001391446.1  DNA-binding protein Ikaros isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL596450

  34. NM_001404518.1 → NP_001391447.1  DNA-binding protein Ikaros isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL596450

  35. NM_001404519.1 → NP_001391448.1  DNA-binding protein Ikaros isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL596450

  36. NM_001404520.1 → NP_001391449.1  DNA-binding protein Ikaros isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL596450

  37. NM_001404521.1 → NP_001391450.1  DNA-binding protein Ikaros isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL596450

  38. NM_001404522.1 → NP_001391451.1  DNA-binding protein Ikaros isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL596450

  39. NM_001404523.1 → NP_001391452.1  DNA-binding protein Ikaros isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL596450

  40. NM_001404524.1 → NP_001391453.1  DNA-binding protein Ikaros isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL596450

  41. NM_001404525.1 → NP_001391454.1  DNA-binding protein Ikaros isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL596450

  42. NM_001404526.1 → NP_001391455.1  DNA-binding protein Ikaros isoform 33

    Status: REVIEWED

    Source sequence(s)
    AL596450

  43. NM_001404527.1 → NP_001391456.1  DNA-binding protein Ikaros isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL596450

  44. NM_001404531.1 → NP_001391460.1  DNA-binding protein Ikaros isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL596450

  45. NM_001404532.1 → NP_001391461.1  DNA-binding protein Ikaros isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL596450

  46. NM_001404533.1 → NP_001391462.1  DNA-binding protein Ikaros isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL596450

  47. NM_001404534.1 → NP_001391463.1  DNA-binding protein Ikaros isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL596450

  48. NM_001404535.1 → NP_001391464.1  DNA-binding protein Ikaros isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL596450

  49. NM_001404537.1 → NP_001391466.1  DNA-binding protein Ikaros isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL596450

  50. NM_001404539.1 → NP_001391468.1  DNA-binding protein Ikaros isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL596450

  51. NM_001404540.1 → NP_001391469.1  DNA-binding protein Ikaros isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL596450

  52. NM_001404542.1 → NP_001391471.1  DNA-binding protein Ikaros isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL596450

  53. NM_001404543.1 → NP_001391472.1  DNA-binding protein Ikaros isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    Q5SWU0

  54. NM_001404544.1 → NP_001391473.1  DNA-binding protein Ikaros isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    Q5SWU0

  55. NM_001404545.1 → NP_001391474.1  DNA-binding protein Ikaros isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    Q5SWU0

  56. NM_001404547.1 → NP_001391476.1  DNA-binding protein Ikaros isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    Q5SWU0

  57. NM_001404549.1 → NP_001391478.1  DNA-binding protein Ikaros isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    Q5SWU0

  58. NM_001404550.1 → NP_001391479.1  DNA-binding protein Ikaros isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL596450

  59. NM_001404551.1 → NP_001391480.1  DNA-binding protein Ikaros isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL596450

  60. NM_001404552.1 → NP_001391481.1  DNA-binding protein Ikaros isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL596450

  61. NM_001404553.1 → NP_001391482.1  DNA-binding protein Ikaros isoform 25

    Status: REVIEWED

    Source sequence(s)
    AL596450

  62. NM_001404554.1 → NP_001391483.1  DNA-binding protein Ikaros isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL596450

  63. NM_001404555.1 → NP_001391484.1  DNA-binding protein Ikaros isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    Q3UQ33

  64. NM_001404556.1 → NP_001391485.1  DNA-binding protein Ikaros isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    Q3UQ33

  65. NM_001404557.1 → NP_001391486.1  DNA-binding protein Ikaros isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL596450
    UniProtKB/TrEMBL
    Q3UQ33

  66. NM_001404558.1 → NP_001391487.1  DNA-binding protein Ikaros isoform 27

    Status: REVIEWED

    Source sequence(s)
    AL596450

  67. NM_001404559.1 → NP_001391488.1  DNA-binding protein Ikaros isoform 27

    Status: REVIEWED

    Source sequence(s)
    AL596450

  68. NM_001404560.1 → NP_001391489.1  DNA-binding protein Ikaros isoform 27

    Status: REVIEWED

    Source sequence(s)
    AL596450

  69. NM_001404561.1 → NP_001391490.1  DNA-binding protein Ikaros isoform 27

    Status: REVIEWED

    Source sequence(s)
    AL596450

  70. NM_001404562.1 → NP_001391491.1  DNA-binding protein Ikaros isoform 28

    Status: REVIEWED

    Source sequence(s)
    AL596450

  71. NM_001404563.1 → NP_001391492.1  DNA-binding protein Ikaros isoform 34

    Status: REVIEWED

    Source sequence(s)
    AL596450
    Related
    ENSMUSP00000159477.1, ENSMUST00000240544.1

  72. NM_001404564.1 → NP_001391493.1  DNA-binding protein Ikaros isoform 29

    Status: REVIEWED

    Source sequence(s)
    AL596450

  73. NM_001404565.1 → NP_001391494.1  DNA-binding protein Ikaros isoform 30

    Status: REVIEWED

    Source sequence(s)
    AL596450

  74. NM_001404567.1 → NP_001391496.1  DNA-binding protein Ikaros isoform 30

    Status: REVIEWED

    Source sequence(s)
    AL596450

  75. NM_001404568.1 → NP_001391497.1  DNA-binding protein Ikaros isoform 30

    Status: REVIEWED

    Source sequence(s)
    AL596450

  76. NM_001404569.1 → NP_001391498.1  DNA-binding protein Ikaros isoform 31

    Status: REVIEWED

    Source sequence(s)
    AL596450

  77. NM_009578.4 → NP_033604.2  DNA-binding protein Ikaros isoform 2

    See identical proteins and their annotated locations for NP_033604.2

    Status: REVIEWED

    Source sequence(s)
    AL596450
    Consensus CDS
    CCDS24437.1
    UniProtKB/Swiss-Prot
    Q03267, Q64044, Q64045, Q64051
    UniProtKB/TrEMBL
    Q5SWU0
    Related
    ENSMUSP00000018798.7, ENSMUST00000018798.7
    Conserved Domains (2) summary
    COG5048
    Location:1 → 131
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:60 → 80
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    11634970..11722930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243705.2 → XP_011242007.1  DNA-binding protein Ikaros isoform X6

    See identical proteins and their annotated locations for XP_011242007.1

    UniProtKB/TrEMBL
    Q571F4
    Conserved Domains (3) summary
    COG5048
    Location:179 → 527
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:155 → 175
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:168 → 192
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011243711.2 → XP_011242013.1  DNA-binding protein Ikaros isoform X1

    See identical proteins and their annotated locations for XP_011242013.1

    UniProtKB/TrEMBL
    Q571F4, Q5SWT9
    Conserved Domains (3) summary
    COG5048
    Location:163 → 511
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:152 → 176
    zf-H2C2_2; Zinc-finger double domain

  3. XM_011243701.3 → XP_011242003.1  DNA-binding protein Ikaros isoform X2

    UniProtKB/TrEMBL
    Q571F4
    Conserved Domains (3) summary
    COG5048
    Location:163 → 501
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:152 → 176
    zf-H2C2_2; Zinc-finger double domain

  4. XM_011243707.3 → XP_011242009.1  DNA-binding protein Ikaros isoform X8

    UniProtKB/TrEMBL
    Q571F4
    Conserved Domains (3) summary
    COG5048
    Location:163 → 466
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:152 → 176
    zf-H2C2_2; Zinc-finger double domain

  5. XM_011243706.3 → XP_011242008.1  DNA-binding protein Ikaros isoform X7

    UniProtKB/TrEMBL
    Q571F4
    Conserved Domains (2) summary
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:152 → 176
    zf-H2C2_2; Zinc-finger double domain

  6. XM_011243713.3 → XP_011242015.1  DNA-binding protein Ikaros isoform X10

    UniProtKB/Swiss-Prot
    Q03267, Q64044, Q64045, Q64051
    Conserved Domains (2) summary
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:152 → 176
    zf-H2C2_2; Zinc-finger double domain

  7. XM_011243703.3 → XP_011242005.1  DNA-binding protein Ikaros isoform X5

    See identical proteins and their annotated locations for XP_011242005.1

    UniProtKB/TrEMBL
    Q571F4
    Conserved Domains (3) summary
    COG5048
    Location:143 → 481
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:119 → 139
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:132 → 156
    zf-H2C2_2; Zinc-finger double domain

  8. XM_011243716.2 → XP_011242018.1  DNA-binding protein Ikaros isoform X14

    UniProtKB/Swiss-Prot
    Q03267, Q64044, Q64045, Q64051
    Conserved Domains (2) summary
    COG5048
    Location:1 → 131
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:60 → 80
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. XM_011243718.2 → XP_011242020.1  DNA-binding protein Ikaros isoform X17

    UniProtKB/TrEMBL
    Q5GGW5
    Conserved Domains (4) summary
    COG5048
    Location:1 → 112
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:60 → 80
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:58 → 80
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:72 → 97
    zf-H2C2_2; Zinc-finger double domain

  10. XM_011243704.3 → XP_011242006.1  DNA-binding protein Ikaros isoform X6

    See identical proteins and their annotated locations for XP_011242006.1

    UniProtKB/TrEMBL
    Q571F4
    Conserved Domains (3) summary
    COG5048
    Location:179 → 527
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:155 → 175
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:168 → 192
    zf-H2C2_2; Zinc-finger double domain

  11. XM_011243710.4 → XP_011242012.1  DNA-binding protein Ikaros isoform X1

    See identical proteins and their annotated locations for XP_011242012.1

    UniProtKB/TrEMBL
    Q571F4, Q5SWT9
    Conserved Domains (3) summary
    COG5048
    Location:163 → 511
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:139 → 159
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:152 → 176
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03267.2 GenPept UniProtKB/Swiss-Prot:Q03267

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