Gsn gelsolin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gsnprovided by MGI
Official Full Name: gelsolinprovided by MGI
Primary source: MGI:MGI:95851
See related: Ensembl:ENSMUSG00000026879 AllianceGenome:MGI:95851
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ADF
Summary: Enables phosphatidylinositol 3-kinase catalytic subunit binding activity. Involved in several processes, including actin filament capping; actin polymerization or depolymerization; and positive regulation of protein processing in phagocytic vesicle. Acts upstream of or within cellular response to interferon-gamma and vesicle-mediated transport. Located in lamellipodium and phagocytic vesicle. Colocalizes with focal adhesion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Finnish type amyloidosis. Orthologous to human GSN (gelsolin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 1628.5), bladder adult (RPKM 1379.3) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 23.5 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (35146371..35197914)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (35256359..35307902)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gelsolin Modulates Platelet Dense Granule Secretion and Hemostasis via the Actin Cytoskeleton.
Title: Gelsolin Modulates Platelet Dense Granule Secretion and Hemostasis via the Actin Cytoskeleton.
The Molecular Chaperone CCT Sequesters Gelsolin and Protects it from Cleavage by Caspase-3.
Title: The Molecular Chaperone CCT Sequesters Gelsolin and Protects it from Cleavage by Caspase-3.
The Pathophysiologic Role of Gelsolin in Chronic Kidney Disease: Focus on Podocytes.
Title: The Pathophysiologic Role of Gelsolin in Chronic Kidney Disease: Focus on Podocytes.
Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.
Title: Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.
Gelsolin is an important mediator of Angiotensin II-induced activation of cardiac fibroblasts and fibrosis.
Title: Gelsolin is an important mediator of Angiotensin II-induced activation of cardiac fibroblasts and fibrosis.
Plasma gelsolin promotes re-epithelialization of the ocular system.
Title: Plasma gelsolin promotes re-epithelialization.
PI3Kalpha drives gelsolin-mediated adverse cytoskeletal remodeling in response to biomechanical stress.
Title: PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.
Induction of cell stress alters the actin cytoskeleton in intestinal epithelial cells via changes in the actin-binding proteins villin-1 and gelsolin.
Title: Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation.
Myelin loss and subsequent axon degeneration contributes to a variety of neurological diseases, such as multiple sclerosis (MS).
Title: LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway.
free actin likely contributes to impaired host defense by blocking scavenger receptor binding of bacteria.
Title: Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (9) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:498432 (e-PCR)
- UniSTS:498432

Gsn (e-PCR), detects polymorphism
- UniSTS:498432

Gsn (e-PCR), detects polymorphism
- UniSTS:474748

Gsn (e-PCR), detects polymorphism
- UniSTS:498384

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin II binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol 3-kinase catalytic subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol 3-kinase catalytic subunit binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament capping	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament capping	ISO Inferred from Sequence Orthology more info
involved_in actin filament depolymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament depolymerization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament severing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament severing	ISO Inferred from Sequence Orthology more info
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin polymerization or depolymerization	ISO Inferred from Sequence Orthology more info
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiac muscle cell contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cadmium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of actin nucleation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein processing in phagocytic vesicle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein destabilization	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of T cell polarity	ISO Inferred from Sequence Orthology more info
involved_in regulation of plasma membrane raft polarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of podosome assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in relaxation of cardiac muscle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in renal protein absorption	ISO Inferred from Sequence Orthology more info
involved_in response to muscle stretch	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sequestering of actin monomers	ISO Inferred from Sequence Orthology more info
involved_in striated muscle atrophy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in actin cap	ISO Inferred from Sequence Orthology more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in apical ectoplasmic specialization	ISO Inferred from Sequence Orthology more info
located_in basal ectoplasmic specialization	ISO Inferred from Sequence Orthology more info
colocalizes_with cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
colocalizes_with focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in glial filament	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in myelin sheath	ISO Inferred from Sequence Orthology more info
colocalizes_with nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info
located_in sarcoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gelsolin

Names: actin-depolymerizing factor; brevin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001206367.1 → NP_001193296.1 gelsolin isoform 2

See identical proteins and their annotated locations for NP_001193296.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).

Source sequence(s)

AK148957, AL773523, BY655071

Consensus CDS

CCDS79785.1

UniProtKB/TrEMBL

Q3U9Q8, Q6PAC1

Related

ENSMUSP00000144561.2, ENSMUST00000201185.4

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:247 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001206368.1 → NP_001193297.1 gelsolin isoform 2

See identical proteins and their annotated locations for NP_001193297.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).

Source sequence(s)

AL773523

Consensus CDS

CCDS79785.1

UniProtKB/TrEMBL

Q3U9Q8, Q6PAC1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:247 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001206369.1 → NP_001193298.1 gelsolin isoform 2

See identical proteins and their annotated locations for NP_001193298.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).

Source sequence(s)

AK166831, BY144206, BY655071

Consensus CDS

CCDS79785.1

UniProtKB/TrEMBL

Q3U9Q8, Q6PAC1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:247 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001362945.1 → NP_001349874.1 gelsolin isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (5), as well as variant 6, encodes isoform 3.

Source sequence(s)

AL773523

UniProtKB/TrEMBL

Q3U9Q8

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:258 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001362947.1 → NP_001349876.1 gelsolin isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (6), as well as variant 5, encodes isoform 3.

Source sequence(s)

AK169041, AL773523, BY064133, CN701174

UniProtKB/TrEMBL

Q3U9Q8

Conserved Domains (6) summary

cd11288
Location:521 → 609

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:146 → 235

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:19 → 131

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:626 → 724

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:258 → 355

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:399 → 499

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_001362948.1 → NP_001349877.1 gelsolin isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (7), as well as variants 2, 3, and 4, encodes isoform 2.

Source sequence(s)

AK169041, AL773523, BY064133, BY195027

Consensus CDS

CCDS79785.1

UniProtKB/TrEMBL

Q3U9Q8, Q6PAC1

Conserved Domains (6) summary

cd11288
Location:510 → 598

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:135 → 224

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:8 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:615 → 713

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:247 → 344

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:388 → 488

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
NM_146120.4 → NP_666232.2 gelsolin isoform 1 precursor

See identical proteins and their annotated locations for NP_666232.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AK143664, AL773523, BY655071

Consensus CDS

CCDS15960.1

UniProtKB/Swiss-Prot

P13020, Q3UPB1, Q8R590

UniProtKB/TrEMBL

Q3U9Q8

Related

ENSMUSP00000028239.7, ENSMUST00000028239.8

Conserved Domains (6) summary

cd11288
Location:559 → 647

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:184 → 273

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:57 → 169

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:664 → 762

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:296 → 393

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:437 → 537

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

35146371..35197914

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497990.4 → XP_006498053.1 gelsolin isoform X1

UniProtKB/TrEMBL

Q3U9Q8

Conserved Domains (6) summary

cd11288
Location:581 → 669

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11289
Location:206 → 295

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:79 → 191

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:686 → 784

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:318 → 415

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd11293
Location:459 → 559

gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins