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Zfx zinc finger protein X-linked [ Mus musculus (house mouse) ]

Gene ID: 22764, updated on 11-Apr-2024

Summary

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Official Symbol
Zfxprovided by MGI
Official Full Name
zinc finger protein X-linkedprovided by MGI
Primary source
MGI:MGI:99211
See related
Ensembl:ENSMUSG00000079509 AllianceGenome:MGI:99211
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfx5; Zfx6; Zfx5,6
Summary
Predicted to enable chromatin insulator sequence binding activity. Acts upstream of or within several processes, including gamete generation; ovarian follicle development; and parental behavior. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in chromosome. Is expressed in several structures, including 4-cell stage embryo; genitourinary system; ileum; liver; and spleen. Orthologous to several human genes including ZFX (zinc finger protein X-linked). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 7.9), CNS E11.5 (RPKM 4.7) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Zfx in Genome Data Viewer
Location:
X C3; X 41.48 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (93118237..93194250, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (94074631..94150645, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 15165 Neighboring gene STARR-seq mESC enhancer starr_47553 Neighboring gene predicted pseudogene 6987 Neighboring gene STARR-seq mESC enhancer starr_47554 Neighboring gene STARR-seq mESC enhancer starr_47555 Neighboring gene predicted gene, 46691 Neighboring gene STARR-seq mESC enhancer starr_47557 Neighboring gene eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked Neighboring gene STARR-seq mESC enhancer starr_47559 Neighboring gene STARR-positive B cell enhancer ABC_E8763 Neighboring gene kelch-like 15 Neighboring gene microRNA 7673

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes. Arenzana TL, et al. Blood, 2009 Jun 4. PMID 19329779, Free PMC Article
  2. Evolution of the Zfx and Zfy genes: rates and interdependence between the genes. Pamilo P, et al. Mol Biol Evol, 1993 Mar. PMID 8487630
  3. The structure of the Zfx gene on the mouse X chromosome. Luoh SW, et al. Genomics, 1994 Jan 15. PMID 8188262
  4. Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis. Zhou Y, et al. Thorac Cancer, 2021 Sep. PMID 34324278, Free PMC Article
  5. RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis. Zhang Y, et al. Mamm Genome, 2017 Apr. PMID 28251288

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis.
    Title: Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis.
  2. our findings show that RNAi-mediated disruption of Zfx/Zfy in mouse testis affected X/Y spermatogenesis. Additionally, results suggest that the paralogous genes Zfx/Zfy play an important role in the process of X and Y sperm development. The individual interference of Zfx/Zfy may predict the outcome of X and Y haploid sperms. Presented herein is an advanced method developed to control mouse X/Y spermatogenesis and sex rati
    Title: RNAi as a tool to control the sex ratio of mouse offspring by interrupting Zfx/Zfy genes in the testis.
  3. Zfx is a common cell-intrinsic regulator of diverse Hedgehog-induced tumors.
    Title: Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway.
  4. Zfx, a transcription factor that controls hematopoietic stem cell self-renewal, controls the initiation and maintenance of acute myeloid leukemia.
    Title: ZFX controls propagation and prevents differentiation of acute T-lymphoblastic and myeloid leukemia.
  5. Zfx restrains the stress response and couples antigen receptor signaling to cell expansion and maintenance during B-cell development and peripheral homeostasis
    Title: Transcription factor Zfx controls BCR-induced proliferation and survival of B lymphocytes.
  6. These studies identify Zfx as a shared transcriptional regulator of embryonic stem cells and hematopoietic stem cells, suggesting a common genetic basis of self-renewal in embryonic and adult SC.
    Title: Zfx controls the self-renewal of embryonic and hematopoietic stem cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin insulator sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryo development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within homeostasis of number of cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within oocyte development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within parental behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger X-chromosomal protein
Names
X-linked zinc finger protein
zinc finger protein X-linked 5
zinc finger protein X-linked 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044386.1 → NP_001037851.1  zinc finger X-chromosomal protein isoform 1

    See identical proteins and their annotated locations for NP_001037851.1

    Status: VALIDATED

    Source sequence(s)
    AL626786, BF022794
    Consensus CDS
    CCDS30276.1
    UniProtKB/Swiss-Prot
    P17011, P17012, P23607
    UniProtKB/TrEMBL
    B1ASD1
    Related
    ENSMUSP00000085423.6, ENSMUST00000088102.12
    Conserved Domains (6) summary
    COG5048
    Location:537 → 674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484 → 504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:713 → 735
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71 → 404
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:727 → 751
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:371 → 451
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  2. NM_001358354.2 → NP_001345283.1  zinc finger X-chromosomal protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P23607
    UniProtKB/TrEMBL
    B7ZN32
    Conserved Domains (5) summary
    COG5048
    Location:487 → 624
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:434 → 454
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:663 → 685
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71 → 354
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:677 → 701
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001358355.2 → NP_001345284.1  zinc finger X-chromosomal protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P23607
    UniProtKB/TrEMBL
    B7ZN32
    Conserved Domains (5) summary
    COG5048
    Location:487 → 624
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:434 → 454
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:663 → 685
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71 → 354
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:677 → 701
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001358356.2 → NP_001345285.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    Consensus CDS
    CCDS30276.1
    UniProtKB/Swiss-Prot
    P17011, P17012, P23607
    UniProtKB/TrEMBL
    B1ASD1
    Conserved Domains (6) summary
    COG5048
    Location:537 → 674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484 → 504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:713 → 735
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71 → 404
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:727 → 751
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:371 → 451
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

  5. NM_001358357.1 → NP_001345286.1  zinc finger X-chromosomal protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626786, BC028506
    Consensus CDS
    CCDS90734.1
    UniProtKB/TrEMBL
    B1ASD2, Q8R2L1
    Related
    ENSMUSP00000109558.2, ENSMUST00000113925.8
    Conserved Domains (1) summary
    pfam04704
    Location:71 → 210
    Zfx_Zfy_act; Zfx / Zfy transcription activation region

  6. NM_001426089.1 → NP_001413018.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P17011, P17012
    UniProtKB/TrEMBL
    B1ASD1

  7. NM_001426091.1 → NP_001413020.1  zinc finger X-chromosomal protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    B7ZN32

  8. NM_001426092.1 → NP_001413021.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P17011, P17012
    UniProtKB/TrEMBL
    B1ASD1

  9. NM_001426093.1 → NP_001413022.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P17011, P17012
    UniProtKB/TrEMBL
    B1ASD1

  10. NM_001426094.1 → NP_001413023.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P17011, P17012
    UniProtKB/TrEMBL
    B1ASD1

  11. NM_001426095.1 → NP_001413024.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P17011, P17012
    UniProtKB/TrEMBL
    B1ASD1

  12. NM_001426096.1 → NP_001413025.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P17011, P17012
    UniProtKB/TrEMBL
    B1ASD1

  13. NM_001426097.1 → NP_001413026.1  zinc finger X-chromosomal protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL626786

  14. NM_001426098.1 → NP_001413027.1  zinc finger X-chromosomal protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL626786

  15. NM_001426099.1 → NP_001413028.1  zinc finger X-chromosomal protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    B7ZN32

  16. NM_001426100.1 → NP_001413029.1  zinc finger X-chromosomal protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    B7ZN32

  17. NM_001426101.1 → NP_001413030.1  zinc finger X-chromosomal protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    B7ZN32

  18. NM_001426102.1 → NP_001413031.1  zinc finger X-chromosomal protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL626786

  19. NM_001426103.1 → NP_001413032.1  zinc finger X-chromosomal protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/Swiss-Prot
    P17011, P17012
    UniProtKB/TrEMBL
    B1ASD1

  20. NM_001426104.1 → NP_001413033.1  zinc finger X-chromosomal protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    Q8R2L1

  21. NM_001426105.1 → NP_001413034.1  zinc finger X-chromosomal protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    Q8R2L1

  22. NM_001426106.1 → NP_001413035.1  zinc finger X-chromosomal protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    Q8R2L1

  23. NM_001426107.1 → NP_001413036.1  zinc finger X-chromosomal protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    Q8R2L1

  24. NM_001426108.1 → NP_001413037.1  zinc finger X-chromosomal protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    Q8R2L1

  25. NM_001426109.1 → NP_001413038.1  zinc finger X-chromosomal protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL626786
    UniProtKB/TrEMBL
    Q8R2L1

  26. NM_011768.2 → NP_035898.2  zinc finger X-chromosomal protein isoform 1

    See identical proteins and their annotated locations for NP_035898.2

    Status: VALIDATED

    Source sequence(s)
    AL626786, BF022794
    Consensus CDS
    CCDS30276.1
    UniProtKB/Swiss-Prot
    P17011, P17012, P23607
    UniProtKB/TrEMBL
    B1ASD1
    Related
    ENSMUSP00000109560.2, ENSMUST00000113927.8
    Conserved Domains (6) summary
    COG5048
    Location:537 → 674
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:484 → 504
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:713 → 735
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:71 → 404
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:727 → 751
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:371 → 451
    ROS_MUCR; ROS/MUCR transcriptional regulator protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    93118237..93194250 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527967.4 → XP_006528030.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    P23607
    Conserved Domains (5) summary
    COG5048
    Location:520 → 644
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:467 → 487
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:696 → 718
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:104 → 387
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:539 → 563
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006527965.4 → XP_006528028.1  zinc finger X-chromosomal protein isoform X1

    UniProtKB/Swiss-Prot
    P23607
    Conserved Domains (4) summary
    COG5048
    Location:570 → 832
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:517 → 537
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:452 → 474
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:104 → 437
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17012.2 GenPept UniProtKB/Swiss-Prot:P17012

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