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Zfp54 zinc finger protein 54 [ Mus musculus (house mouse) ]

Gene ID: 22712, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp54provided by MGI
Official Full Name
zinc finger protein 54provided by MGI
Primary source
MGI:MGI:99201
See related
Ensembl:ENSMUSG00000023882 AllianceGenome:MGI:99201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp76; KRAB10; Zfp-54; mszf83; 2810034D10Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including frenulum; genitourinary system; liver; lung; and spleen. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 1.9), testis adult (RPKM 1.3) and 24 other tissues See more
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Genomic context

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Location:
17 A3.2; 17 11.4 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (21643489..21655646)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (21423227..21435384)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 677 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7494 Neighboring gene zinc finger protein 677 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_42007 Neighboring gene STARR-positive B cell enhancer ABC_E9941 Neighboring gene STARR-positive B cell enhancer ABC_E8655 Neighboring gene zinc finger protein 51 Neighboring gene STARR-seq mESC enhancer starr_42008 Neighboring gene STARR-seq mESC enhancer starr_42009 Neighboring gene predicted gene, 52290

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Localization and differential expression of the Krüppel-associated box zinc finger proteins 1 and 54 in early mouse development. Albertsen M, et al. DNA Cell Biol, 2010 Oct. PMID 20624068
  2. Molecular characterization of Zfp54, a zinc-finger-containing gene that is deleted in the embryonic lethal mutation tw18. Shannon M, et al. Mamm Genome, 1999 Jul. PMID 10384051
  3. A cluster of related zinc finger protein genes is deleted in the mouse embryonic lethal mutation tw18. Crossley PH, et al. Proc Natl Acad Sci U S A, 1991 Sep 15. PMID 1680234, Free PMC Article
  4. Physical analysis of the region deleted in the tw18 allele of the mouse tcl-4 complementation group. Barclay J, et al. Genomics, 1996 Aug 15. PMID 8812414
  5. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Taken together, this suggests a role for ZFP1 and ZFP54 in transcriptional regulation in early development.
    Title: Localization and differential expression of the Krüppel-associated box zinc finger proteins 1 and 54 in early mouse development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • MGC91117

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 54
Names
Krueppel-associated box protein 10
clone 18
zinc finger protein 76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379356.1 → NP_001366285.1  zinc finger protein 54 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT009594, CT010433
    UniProtKB/Swiss-Prot
    E9PW05, O88631, Q66JT2, Q6R5P4
    Related
    ENSMUSP00000132983.2, ENSMUST00000165230.8
    Conserved Domains (4) summary
    COG5048
    Location:98 → 504
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:491 → 571
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:469 → 489
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box

  2. NM_001379357.1 → NP_001366286.1  zinc finger protein 54 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT009594, CT010433
    UniProtKB/Swiss-Prot
    E9PW05, O88631, Q66JT2, Q6R5P4
    Conserved Domains (4) summary
    COG5048
    Location:98 → 504
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:491 → 571
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:469 → 489
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box

  3. NM_001379358.1 → NP_001366287.1  zinc finger protein 54 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT009594, CT010433
    UniProtKB/Swiss-Prot
    E9PW05, O88631, Q66JT2, Q6R5P4
    Conserved Domains (4) summary
    COG5048
    Location:98 → 504
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:491 → 571
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:469 → 489
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box

  4. NM_001379359.1 → NP_001366288.1  zinc finger protein 54 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT009594, CT010433
    Conserved Domains (4) summary
    COG5048
    Location:138 → 544
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:531 → 611
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:509 → 529
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:52 → 92
    KRAB; KRAB box

  5. NM_011760.2 → NP_035890.2  zinc finger protein 54 isoform 1

    See identical proteins and their annotated locations for NP_035890.2

    Status: VALIDATED

    Source sequence(s)
    CT009594, CT010433
    Consensus CDS
    CCDS37462.1
    UniProtKB/Swiss-Prot
    E9PW05, O88631, Q66JT2, Q6R5P4
    Related
    ENSMUSP00000007884.9, ENSMUST00000007884.15
    Conserved Domains (4) summary
    COG5048
    Location:98 → 504
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:491 → 571
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:469 → 489
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    21643489..21655646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249760.1 → XP_030105620.1  zinc finger protein 54 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:21 → 427
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:414 → 494
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:392 → 412
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9PW05.1 GenPept UniProtKB/Swiss-Prot:E9PW05

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