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Zfp46 zinc finger protein 46 [ Mus musculus (house mouse) ]

Gene ID: 22704, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp46provided by MGI
Official Full Name
zinc finger protein 46provided by MGI
Primary source
MGI:MGI:99192
See related
Ensembl:ENSMUSG00000051351 AllianceGenome:MGI:99192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mlz-4; Zfp-46; Znf436
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Is expressed in ganglia; genitourinary system; and hindbrain. Orthologous to human ZNF436 (zinc finger protein 436). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 13.1), whole brain E14.5 (RPKM 12.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D3; 4 68.34 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136011479..136021163)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136284168..136293942)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11749 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 Neighboring gene STARR-seq mESC enhancer starr_11750 Neighboring gene transcription elongation factor A (SII), 3 Neighboring gene STARR-positive B cell enhancer ABC_E9604 Neighboring gene STARR-positive B cell enhancer ABC_E4689 Neighboring gene STARR-seq mESC enhancer starr_11754 Neighboring gene STARR-seq mESC enhancer starr_11755 Neighboring gene heterogeneous nuclear ribonucleoprotein R Neighboring gene predicted gene, 54262 Neighboring gene predicted gene, 31295

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of a novel zinc-finger protein-encoding cDNA from the mouse eye lens. Brady JP, et al. Gene, 1993 Feb 28. PMID 8444344
  2. Mapping of two zinc finger protein genes to mouse chromosomes 4 and 7. Denny P, et al. Mamm Genome, 1995 Sep. PMID 8535085
  3. A mechanism misregulating p27 in tumors discovered in a functional genomic screen. Garrett-Engele CM, et al. PLoS Genet, 2007 Dec. PMID 18069898, Free PMC Article
  4. G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator. Zhang D, et al. J Biol Chem, 2008 Mar 28. PMID 18218630, Free PMC Article
  5. Chromosomal localization of the genes for five zinc finger proteins expressed in mouse lens. Danciger M, et al. Genomics, 1995 Jul 1. PMID 7590745

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 436
Names
zinc finger protein MLZ-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356308.2 → NP_001343237.1  zinc finger protein 436 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL935264
    Consensus CDS
    CCDS18804.1
    UniProtKB/Swiss-Prot
    Q03309, Q69ZC6, Q8BPP0, Q8BQC2
    Conserved Domains (3) summary
    smart00349
    Location:1 → 64
    KRAB; krueppel associated box
    COG5048
    Location:145 → 452
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178 → 198
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001370651.2 → NP_001357580.1  zinc finger protein 436 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL935264
    Conserved Domains (3) summary
    COG5048
    Location:163 → 470
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:196 → 216
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:13 → 54
    KRAB; KRAB box

  3. NM_001425037.1 → NP_001411966.1  zinc finger protein 436 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL935264

  4. NM_001425038.1 → NP_001411967.1  zinc finger protein 436 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL935264
    UniProtKB/Swiss-Prot
    Q03309, Q69ZC6, Q8BPP0, Q8BQC2

  5. NM_009557.5 → NP_033583.2  zinc finger protein 436 isoform 1

    See identical proteins and their annotated locations for NP_033583.2

    Status: VALIDATED

    Source sequence(s)
    AL935264
    Consensus CDS
    CCDS18804.1
    UniProtKB/Swiss-Prot
    Q03309, Q69ZC6, Q8BPP0, Q8BQC2
    Related
    ENSMUSP00000070216.5, ENSMUST00000069195.5
    Conserved Domains (3) summary
    smart00349
    Location:1 → 64
    KRAB; krueppel associated box
    COG5048
    Location:145 → 452
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178 → 198
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    136011479..136021163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163984.1 → XP_036019877.1  zinc finger protein 436 isoform X2

    UniProtKB/Swiss-Prot
    Q03309, Q69ZC6, Q8BPP0, Q8BQC2
    Conserved Domains (3) summary
    smart00349
    Location:1 → 64
    KRAB; krueppel associated box
    COG5048
    Location:145 → 452
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178 → 198
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006538728.1 → XP_006538791.1  zinc finger protein 436 isoform X1

    See identical proteins and their annotated locations for XP_006538791.1

    Conserved Domains (3) summary
    COG5048
    Location:163 → 470
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:196 → 216
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:13 → 54
    KRAB; KRAB box
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BPP0.1 GenPept UniProtKB/Swiss-Prot:Q8BPP0

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