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Zfp37 zinc finger protein 37 [ Mus musculus (house mouse) ]

Gene ID: 22696, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp37provided by MGI
Official Full Name
zinc finger protein 37provided by MGI
Primary source
MGI:MGI:99181
See related
Ensembl:ENSMUSG00000028389 AllianceGenome:MGI:99181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tzn; Zfp-37
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within germ cell development. Predicted to be located in nucleus. Is expressed in several structures, including early conceptus; foregut; and genitourinary system. Orthologous to human ZFP37 (ZFP37 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 14.6), CNS E11.5 (RPKM 4.2) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp37 in Genome Data Viewer
Location:
4 B3; 4 33.04 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (62107777..62126685, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (62189537..62209129, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12909 Neighboring gene STARR-seq mESC enhancer starr_10409 Neighboring gene major urinary protein 21 Neighboring gene STARR-seq mESC enhancer starr_10410 Neighboring gene STARR-seq mESC enhancer starr_10411 Neighboring gene STARR-seq mESC enhancer starr_10413 Neighboring gene STARR-seq mESC enhancer starr_10414 Neighboring gene predicted gene, 30511 Neighboring gene STARR-positive B cell enhancer ABC_E4633 Neighboring gene STARR-seq mESC enhancer starr_10417 Neighboring gene predicted gene, 23148

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zfp-37 is a member of the KRAB zinc finger gene family and is expressed in neurons of the developing and adult CNS. Mazarakis N, et al. Genomics, 1996 Apr 15. PMID 8660973
  2. Cloning and sequencing of a zinc finger cDNA expressed in mouse testis. Nelki D, et al. Nucleic Acids Res, 1990 Jun 25. PMID 2114017, Free PMC Article
  3. The centromeric/nucleolar chromatin protein ZFP-37 may function to specify neuronal nuclear domains. Payen E, et al. J Biol Chem, 1998 Apr 10. PMID 9535899
  4. Zfp-37, a new murine zinc finger encoding gene, is expressed in a developmentally regulated pattern in the male germ line. Burke PS, et al. Nucleic Acids Res, 1992 Jun 11. PMID 1614869, Free PMC Article
  5. Linkage analysis of the whirler deafness gene on mouse chromosome 4. Fleming J, et al. Genomics, 1994 May 1. PMID 8088814

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within germ cell development TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 37
Names
male germ cell-specific zinc finger protein
zinc finger protein 37 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290350.2 → NP_001277279.1  zinc finger protein 37 isoform 1

    See identical proteins and their annotated locations for NP_001277279.1

    Status: VALIDATED

    Source sequence(s)
    AL683829
    Consensus CDS
    CCDS71400.1
    UniProtKB/Swiss-Prot
    P17141, Q62514, Q80YX7
    Related
    ENSMUSP00000070463.4, ENSMUST00000068822.4
    Conserved Domains (6) summary
    cd07765
    Location:15 → 42
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:15 → 62
    KRAB; krueppel associated box
    COG5048
    Location:124 → 486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:397 → 417
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:451 → 473
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:353 → 378
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001290351.2 → NP_001277280.1  zinc finger protein 37 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL683829
    Consensus CDS
    CCDS89756.1
    UniProtKB/TrEMBL
    A0A1Y7VLM5
    Related
    ENSMUSP00000152266.2, ENSMUST00000221329.2
    Conserved Domains (6) summary
    cd07765
    Location:1 → 39
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:12 → 59
    KRAB; krueppel associated box
    COG5048
    Location:121 → 483
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:394 → 414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:448 → 470
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:350 → 375
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001290353.2 → NP_001277282.1  zinc finger protein 37 isoform 4

    See identical proteins and their annotated locations for NP_001277282.1

    Status: VALIDATED

    Source sequence(s)
    AL683829
    Consensus CDS
    CCDS89754.1
    UniProtKB/TrEMBL
    A0A1Y7VJF3
    Related
    ENSMUSP00000152400.2, ENSMUST00000222748.2
    Conserved Domains (3) summary
    COG5048
    Location:83 → 445
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:356 → 376
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:509 → 533
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001348347.2 → NP_001335276.1  zinc finger protein 37 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL683829
    Consensus CDS
    CCDS89754.1
    UniProtKB/TrEMBL
    A0A1Y7VJF3
    Conserved Domains (3) summary
    COG5048
    Location:83 → 445
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:356 → 376
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:509 → 533
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001424895.1 → NP_001411824.1  zinc finger protein 37 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL683829

  6. NM_009554.5 → NP_033580.3  zinc finger protein 37 isoform 2

    See identical proteins and their annotated locations for NP_033580.3

    Status: VALIDATED

    Source sequence(s)
    AL683829
    Consensus CDS
    CCDS89755.1
    UniProtKB/TrEMBL
    Q6P3Z4
    Related
    ENSMUSP00000152491.2, ENSMUST00000222050.2
    Conserved Domains (6) summary
    cd07765
    Location:1 → 38
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:9 → 58
    KRAB; krueppel associated box
    COG5048
    Location:120 → 482
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393 → 413
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:447 → 469
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:349 → 374
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_188978.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL683829

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    62107777..62126685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17141.4 GenPept UniProtKB/Swiss-Prot:P17141

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