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Zfp1 zinc finger protein 1 [ Mus musculus (house mouse) ]

Gene ID: 22640, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp1provided by MGI
Official Full Name
zinc finger protein 1provided by MGI
Primary source
MGI:MGI:99154
See related
Ensembl:ENSMUSG00000055835 AllianceGenome:MGI:99154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fnp-1; Zfp-1; mkr-1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including extraembryonic component; genitourinary system; hemolymphoid system gland; liver; and lung. Orthologous to human ZFP1 (ZFP1 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 7.6), CNS E14 (RPKM 6.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 E1; 8 57.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112366606..112397740)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111643443..111671108)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 59 Neighboring gene STARR-positive B cell enhancer ABC_E112 Neighboring gene STARR-seq mESC enhancer starr_22698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114079308-114079417 Neighboring gene STARR-positive B cell enhancer ABC_E5041 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114087696-114087913 Neighboring gene zinc and ring finger 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114116137-114116338 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114119771-114119993 Neighboring gene STARR-seq mESC enhancer starr_22705 Neighboring gene STARR-positive B cell enhancer ABC_E9323 Neighboring gene STARR-positive B cell enhancer ABC_E885 Neighboring gene STARR-positive B cell enhancer ABC_E5042 Neighboring gene STARR-seq mESC enhancer starr_22707 Neighboring gene STARR-seq mESC enhancer starr_22708 Neighboring gene lactate dehydrogenase D Neighboring gene STARR-positive B cell enhancer ABC_E10523 Neighboring gene microRNA 7076 Neighboring gene chymotrypsinogen B1 Neighboring gene VISTA enhancer mm1686 Neighboring gene breast cancer anti-estrogen resistance 1 Neighboring gene predicted gene, 51589

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Localization and differential expression of the Krüppel-associated box zinc finger proteins 1 and 54 in early mouse development. Albertsen M, et al. DNA Cell Biol, 2010 Oct. PMID 20624068
  2. A multigene family encoding several "finger" structures is present and differentially active in mammalian genomes. Chowdhury K, et al. Cell, 1987 Mar 13. PMID 3815523
  3. Structure, expression and chromosomal localization of Zfp-1, a murine zinc finger protein gene. Chowdhury K, et al. Nucleic Acids Res, 1989 Dec 25. PMID 2574853, Free PMC Article
  4. Assignment of Amog (adhesion molecule on glia) gene to mouse chromosome 11 near Zfp-3 and Asgr-1,2 and to human chromosome 17. Hsieh CL, et al. Somat Cell Mol Genet, 1990 Jul. PMID 1699290
  5. Zinc finger protein gene complexes on mouse chromosomes 8 and 11. Nadeau JH, et al. Genomics, 1990 Nov. PMID 1981050

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Taken together, this suggests a role for ZFP1 and ZFP54 in transcriptional regulation in early development.
    Title: Localization and differential expression of the Krüppel-associated box zinc finger proteins 1 and 54 in early mouse development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 1
Names
protein mKR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037665.2 → NP_001032754.1  zinc finger protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001032754.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    BC062970, BF719052, X16493
    Consensus CDS
    CCDS22678.1
    UniProtKB/TrEMBL
    Q3UI68
    Related
    ENSMUSP00000076964.7, ENSMUST00000077791.8
    Conserved Domains (4) summary
    COG5048
    Location:175 → 336
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:325 → 345
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 47
    KRAB; KRAB box
    pfam13465
    Location:366 → 390
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001358993.1 → NP_001345922.1  zinc finger protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate frame-shifting splice site, compared to variant 1, which results in the use of an in-frame downstream start codon and a protein (isoform 3) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC122364, AK153830
    Consensus CDS
    CCDS90463.1
    UniProtKB/TrEMBL
    A0A1D5RLU7
    Related
    ENSMUSP00000148511.2, ENSMUST00000212072.2
    Conserved Domains (3) summary
    COG5048
    Location:142 → 303
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:292 → 312
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:333 → 357
    zf-H2C2_2; Zinc-finger double domain

  3. NM_011742.2 → NP_035872.2  zinc finger protein 1 isoform 2

    See identical proteins and their annotated locations for NP_035872.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AC122364, X16493
    Consensus CDS
    CCDS85614.1
    UniProtKB/TrEMBL
    A0A1D5RLC5
    Related
    ENSMUSP00000148310.2, ENSMUST00000211926.2
    Conserved Domains (4) summary
    COG5048
    Location:161 → 322
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:311 → 331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 33
    KRAB; KRAB box
    pfam13465
    Location:352 → 376
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_156445.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122364
    Related
    ENSMUST00000212206.2

  2. NR_156446.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC122364

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    112366606..112397740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153883.1 → XP_036009776.1  zinc finger protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A1D5RLU7
    Conserved Domains (3) summary
    COG5048
    Location:142 → 303
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:292 → 312
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:333 → 357
    zf-H2C2_2; Zinc-finger double domain

  2. XM_030243418.2 → XP_030099278.1  zinc finger protein 1 isoform X1

    UniProtKB/TrEMBL
    Q3UI68
    Conserved Domains (4) summary
    COG5048
    Location:175 → 336
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:325 → 345
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 47
    KRAB; KRAB box
    pfam13465
    Location:366 → 390
    zf-H2C2_2; Zinc-finger double domain

  3. XM_030243420.2 → XP_030099280.1  zinc finger protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A1D5RLC5
    Conserved Domains (4) summary
    COG5048
    Location:161 → 322
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:311 → 331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 33
    KRAB; KRAB box
    pfam13465
    Location:352 → 376
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08042.3 GenPept UniProtKB/Swiss-Prot:P08042

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