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Eno4 enolase 4 [ Mus musculus (house mouse) ]

Gene ID: 226265, updated on 11-Apr-2024

Summary

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Official Symbol
Eno4provided by MGI
Official Full Name
enolase 4provided by MGI
Primary source
MGI:MGI:2441717
See related
Ensembl:ENSMUSG00000048029 AllianceGenome:MGI:2441717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6430537H07Rik
Summary
Enables phosphopyruvate hydratase activity. Acts upstream of or within cilium organization; flagellated sperm motility; and glycolytic process. Located in sperm principal piece. Is expressed in choroid invagination; embryo; metencephalon part of 4th ventricle choroid plexus; and olfactory epithelium. Orthologous to human ENO4 (enolase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 4.2), lung adult (RPKM 0.5) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Eno4 in Genome Data Viewer
Location:
19 D2; 19 54.55 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (58922490..58959853)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (58934058..58971421)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene heat shock protein 12A Neighboring gene predicted gene, 52393 Neighboring gene STARR-seq mESC enhancer starr_46588 Neighboring gene microRNA 3086 Neighboring gene STARR-seq mESC enhancer starr_46589 Neighboring gene shootin 1 Neighboring gene predicted gene, 57667

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility. Nakamura N, et al. Biol Reprod, 2013 Apr. PMID 23446454, Free PMC Article
  2. Integrated microarray and ChIP analysis identifies multiple Foxa2 dependent target genes in the notochord. Tamplin OJ, et al. Dev Biol, 2011 Dec 15. PMID 22008794
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ENO4 is required for normal assembly of the fibrous sheath and provides most of the enolase activity in sperm.
    Title: Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

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Homology

Clone Names

  • MGC30738

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphopyruvate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphopyruvate hydratase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cilium organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of phosphopyruvate hydratase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
enolase 4
Names
2-phospho-D-glycerate hydro-lyase
enolase-like protein C10orf134 homolog
enolase-like protein ENO4
NP_848804.2
XP_006527117.1
XP_006527118.1
XP_006527119.1
XP_030106782.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178689.5 → NP_848804.2  enolase 4

    Status: VALIDATED

    Source sequence(s)
    AC102604
    Consensus CDS
    CCDS79725.1
    UniProtKB/Swiss-Prot
    E9QLA7, Q8BVS9, Q8C042, Q8CFL9
    UniProtKB/TrEMBL
    A0A0J9YUP0
    Related
    ENSMUSP00000144272.2, ENSMUST00000200910.4
    Conserved Domains (2) summary
    TIGR01060
    Location:68 → 570
    eno; phosphopyruvate hydratase
    cl21457
    Location:236 → 569
    TIM_phosphate_binding; TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    58922490..58959853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527054.4 → XP_006527117.1  enolase 4 isoform X1

    UniProtKB/Swiss-Prot
    E9QLA7, Q8BVS9, Q8C042, Q8CFL9
    Conserved Domains (1) summary
    TIGR01060
    Location:68 → 570
    eno; phosphopyruvate hydratase

  2. XM_006527055.4 → XP_006527118.1  enolase 4 isoform X2

    UniProtKB/Swiss-Prot
    E9QLA7, Q8BVS9, Q8C042, Q8CFL9
    Conserved Domains (1) summary
    TIGR01060
    Location:68 → 507
    eno; phosphopyruvate hydratase

  3. XM_006527056.4 → XP_006527119.1  enolase 4 isoform X3

    UniProtKB/Swiss-Prot
    E9QLA7, Q8BVS9, Q8C042, Q8CFL9
    Conserved Domains (1) summary
    TIGR01060
    Location:68 → 507
    eno; phosphopyruvate hydratase

  4. XM_030250922.1 → XP_030106782.1  enolase 4 isoform X4

    UniProtKB/TrEMBL
    A0A0J9YVG9
    Related
    ENSMUSP00000144656.2, ENSMUST00000202382.4
    Conserved Domains (1) summary
    TIGR01060
    Location:2 → 333
    eno; phosphopyruvate hydratase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C042.2 GenPept UniProtKB/Swiss-Prot:Q8C042

Gene LinkOut

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