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Wac WW domain containing adaptor with coiled-coil [ Mus musculus (house mouse) ]

Gene ID: 225131, updated on 16-Apr-2024

Summary

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Official Symbol
Wacprovided by MGI
Official Full Name
WW domain containing adaptor with coiled-coilprovided by MGI
Primary source
MGI:MGI:2387357
See related
Ensembl:ENSMUSG00000024283 AllianceGenome:MGI:2387357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wwp4; 1110067P07Rik; A230035H12Rik
Summary
Predicted to enable RNA polymerase II complex binding activity and chromatin binding activity. Predicted to be involved in several processes, including histone ubiquitination; positive regulation of TORC1 signaling; and regulation of cellular catabolic process. Predicted to act upstream of or within chromatin organization. Part of spliceosomal complex. Orthologous to human WAC (WW domain containing adaptor with coiled-coil). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 13.8), CNS E14 (RPKM 12.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 A1; 18 4.62 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (7868614..7929028)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (7868825..7929028)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene high mobility group AT-hook I, related sequence 1 pseudogene Neighboring gene predicted gene, 24292 Neighboring gene STARR-seq mESC enhancer starr_43747 Neighboring gene STARR-positive B cell enhancer ABC_E7572 Neighboring gene predicted gene 9993 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43748 Neighboring gene STARR-seq mESC enhancer starr_43749 Neighboring gene ribosomal protein S4, X-linked pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The histone H2B ubiquitination regulator Wac is essential for plasma cell differentiation. Li Y, et al. FEBS Lett, 2023 Jul. PMID 37171241
  2. A single-copy Sleeping Beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes. de la Rosa J, et al. Nat Genet, 2017 May. PMID 28319090, Free PMC Article
  3. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. Xu GM, et al. Genomics, 2002 Jan. PMID 11827461
  4. VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase-mediated membrane fusion. Totsukawa G, et al. EMBO J, 2011 Aug 2. PMID 21811234, Free PMC Article
  5. Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing. Parras A, et al. Nature, 2018 Aug. PMID 30111840, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression analyses of WAC, a responsible gene for neurodevelopmental disorders, during mouse brain development.
    Title: Expression analyses of WAC, a responsible gene for neurodevelopmental disorders, during mouse brain development.
  2. The histone H2B ubiquitination regulator Wac is essential for plasma cell differentiation.
    Title: The histone H2B ubiquitination regulator Wac is essential for plasma cell differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II complex binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G1 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
WW domain-containing adapter protein with coiled-coil
Names
WW domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146298.2 → NP_001139770.1  WW domain-containing adapter protein with coiled-coil isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is missing an internal coding exon compared to transcript variant 1. However, it maintains the same reading frame and encodes an isoform (2) which is 103 aa shorter than isoform 1.
    Source sequence(s)
    AC147624, AK079535, AK142196, AV585521, AW556980, BB737328, BC080851, BF461147, CA561963, CB524834, CJ054063, CO432980, DV042656
    Consensus CDS
    CCDS50218.1
    UniProtKB/TrEMBL
    E9Q020
    Related
    ENSMUSP00000089746.5, ENSMUST00000092112.11
    Conserved Domains (2) summary
    pfam00397
    Location:133 → 160
    WW; WW domain
    cl21494
    Location:320 → 425
    Abhydrolase; alpha/beta hydrolases

  2. NM_001282093.1 → NP_001269022.1  WW domain-containing adapter protein with coiled-coil isoform 3

    See identical proteins and their annotated locations for NP_001269022.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC130718, AC147624, AK079535, AK142196, AV585521, BB709347, BG083129, BM948716, BP766478, CB249484, CN668018, DV042656
    Consensus CDS
    CCDS70869.1
    UniProtKB/TrEMBL
    E9Q5D5
    Related
    ENSMUSP00000074454.5, ENSMUST00000074919.11
    Conserved Domains (2) summary
    PHA03247
    Location:172 → 483
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:88 → 115
    WW; WW domain

  3. NM_001360956.1 → NP_001347885.1  WW domain-containing adapter protein with coiled-coil isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4z) uses an alternate 5' structure, and thus differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (3) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC130718, AC147624
    Consensus CDS
    CCDS70869.1
    UniProtKB/TrEMBL
    E9Q5D5
    Conserved Domains (2) summary
    PHA03247
    Location:172 → 483
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:88 → 115
    WW; WW domain

  4. NM_153085.4 → NP_694725.3  WW domain-containing adapter protein with coiled-coil isoform 1

    See identical proteins and their annotated locations for NP_694725.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC147624, AK079535, AK142196, AV585521, AW556980, BB737328, BC080851, CB524834, CJ054063, DV042656
    Consensus CDS
    CCDS29046.1
    UniProtKB/Swiss-Prot
    Q3U0K1, Q66JM9, Q69Z92, Q8C2W2, Q8C8Q8, Q924H7
    UniProtKB/TrEMBL
    E9Q5D5
    Related
    ENSMUSP00000132117.2, ENSMUST00000167020.8
    Conserved Domains (2) summary
    pfam00397
    Location:133 → 160
    WW; WW domain
    cl21494
    Location:423 → 528
    Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    7868614..7929028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250418.2 → XP_030106278.1  WW domain-containing adapter protein with coiled-coil isoform X8

    UniProtKB/TrEMBL
    E9Q020
    Related
    ENSMUSP00000133185.2, ENSMUST00000171042.8
    Conserved Domains (2) summary
    PHA03247
    Location:137 → 380
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:88 → 115
    WW; WW domain

  2. XM_030250417.2 → XP_030106277.1  WW domain-containing adapter protein with coiled-coil isoform X4

    UniProtKB/TrEMBL
    E9Q5D5
    Related
    ENSMUSP00000128321.2, ENSMUST00000172018.8
    Conserved Domains (2) summary
    PHA03247
    Location:172 → 480
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:88 → 115
    WW; WW domain

  3. XM_011246888.3 → XP_011245190.1  WW domain-containing adapter protein with coiled-coil isoform X9

    See identical proteins and their annotated locations for XP_011245190.1

    UniProtKB/TrEMBL
    E9Q5D5
    Conserved Domains (2) summary
    PHA03247
    Location:172 → 483
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:88 → 115
    WW; WW domain

  4. XM_030250416.2 → XP_030106276.1  WW domain-containing adapter protein with coiled-coil isoform X3

    UniProtKB/TrEMBL
    E9Q5D5
    Conserved Domains (2) summary
    PHA03247
    Location:217 → 525
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:133 → 160
    WW; WW domain

  5. XM_036161088.1 → XP_036016981.1  WW domain-containing adapter protein with coiled-coil isoform X7

    UniProtKB/TrEMBL
    E9Q020
    Conserved Domains (2) summary
    PHA03247
    Location:182 → 422
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:133 → 160
    WW; WW domain

  6. XM_006525803.4 → XP_006525866.1  WW domain-containing adapter protein with coiled-coil isoform X1

    UniProtKB/TrEMBL
    E9Q5D5
    Conserved Domains (2) summary
    PHA03247
    Location:223 → 534
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:139 → 166
    WW; WW domain

  7. XM_006525804.4 → XP_006525867.1  WW domain-containing adapter protein with coiled-coil isoform X2

    UniProtKB/TrEMBL
    E9Q5D5
    Conserved Domains (2) summary
    PHA03247
    Location:223 → 531
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:139 → 166
    WW; WW domain

  8. XM_006525806.4 → XP_006525869.1  WW domain-containing adapter protein with coiled-coil isoform X5

    UniProtKB/TrEMBL
    E9Q020
    Conserved Domains (2) summary
    PHA03247
    Location:188 → 431
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:139 → 166
    WW; WW domain

  9. XM_006525807.4 → XP_006525870.1  WW domain-containing adapter protein with coiled-coil isoform X6

    UniProtKB/TrEMBL
    E9Q020
    Conserved Domains (2) summary
    pfam05109
    Location:203 → 453
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00397
    Location:139 → 166
    WW; WW domain

  10. XM_017317866.3 → XP_017173355.1  WW domain-containing adapter protein with coiled-coil isoform X8

    UniProtKB/TrEMBL
    E9Q020
    Conserved Domains (2) summary
    PHA03247
    Location:137 → 380
    PHA03247; large tegument protein UL36; Provisional
    pfam00397
    Location:88 → 115
    WW; WW domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q924H7.2 GenPept UniProtKB/Swiss-Prot:Q924H7

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