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Bag6 BCL2-associated athanogene 6 [ Mus musculus (house mouse) ]

Gene ID: 224727, updated on 11-Apr-2024

Summary

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Official Symbol
Bag6provided by MGI
Official Full Name
BCL2-associated athanogene 6provided by MGI
Primary source
MGI:MGI:1919439
See related
Ensembl:ENSMUSG00000024392 AllianceGenome:MGI:1919439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G3; Bat3; BAG-6; Scythe; D17H6S52E; 2410045D21Rik
Summary
Enables Hsp70 protein binding activity; polyubiquitin modification-dependent protein binding activity; and proteasome binding activity. Involved in several processes, including animal organ development; protein stabilization; and synaptonemal complex assembly. Acts upstream of or within negative regulation of apoptotic process. Located in cytosol and nucleus. Is expressed in palatal shelf epithelium. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human BAG6 (BAG cochaperone 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 225.5), adrenal adult (RPKM 122.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 18.59 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35354132..35366297)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35135156..35147321)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene DNA segment, Chr 17, human D6S53E Neighboring gene apolipoprotein M Neighboring gene STARR-positive B cell enhancer ABC_E5599 Neighboring gene proline-rich coiled-coil 2A Neighboring gene STARR-positive B cell enhancer ABC_E3201 Neighboring gene STARR-positive B cell enhancer ABC_E2486 Neighboring gene predicted gene, 23442 Neighboring gene STARR-positive B cell enhancer ABC_E5600 Neighboring gene allograft inflammatory factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BCL2-associated athanogene 6 exon24 contributes to testosterone synthesis and male fertility in mammals. Song H, et al. Cell Prolif, 2022 Jul. PMID 35688694, Free PMC Article
  2. Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function. Tang R, et al. Sci Immunol, 2022 Mar 11. PMID 35275752, Free PMC Article
  3. HLA-B-associated transcript 3 (Bat3/Scythe) negatively regulates Smad phosphorylation in BMP signaling. Goto K, et al. Cell Death Dis, 2011 Dec 1. PMID 22130070, Free PMC Article
  4. The human BAT3 ortholog in rodents is predominantly and developmentally expressed in testis. Wang R, et al. Mol Cell Biochem, 1994 Jul 13. PMID 7854331
  5. Down-regulation of HLA-B-associated transcript 3 impairs the tumoricidal effect of natural killer cells through promoting the T cell immunoglobulin and mucin domain-containing-3 signaling in a mouse head and neck squamous cell carcinoma model. Yang J, et al. Immunobiology, 2022 Jan. PMID 34968777

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly.
    Title: BAG6 inhibits influenza A virus replication by inducing viral polymerase subunit PB2 degradation and perturbing RdRp complex assembly.
  2. BAG6 negatively regulates the RLR signaling pathway by targeting VISA/MAVS.
    Title: BAG6 negatively regulates the RLR signaling pathway by targeting VISA/MAVS.
  3. BCL2-associated athanogene 6 exon24 contributes to testosterone synthesis and male fertility in mammals.
    Title: BCL2-associated athanogene 6 exon24 contributes to testosterone synthesis and male fertility in mammals.
  4. Down-regulation of HLA-B-associated transcript 3 impairs the tumoricidal effect of natural killer cells through promoting the T cell immunoglobulin and mucin domain-containing-3 signaling in a mouse head and neck squamous cell carcinoma model.
    Title: Down-regulation of HLA-B-associated transcript 3 impairs the tumoricidal effect of natural killer cells through promoting the T cell immunoglobulin and mucin domain-containing-3 signaling in a mouse head and neck squamous cell carcinoma model.
  5. Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function.
    Title: Tim-3 adapter protein Bat3 acts as an endogenous regulator of tolerogenic dendritic cell function.
  6. BAG6 contributes to glucose uptake by supporting the cell surface translocation of the glucose transporter GLUT4.
    Title: BAG6 contributes to glucose uptake by supporting the cell surface translocation of the glucose transporter GLUT4.
  7. The cleft palate candidate gene BAG6 supports FoxO1 acetylation topromote FasL-mediated apoptosis during palate fusion.
    Title: The cleft palate candidate gene BAG6 supports FoxO1 acetylation to promote FasL-mediated apoptosis during palate fusion.
  8. BAT3 negatively regulates lipopolysaccharide-induced NF-kappaB signaling through TRAF6.
    Title: BAT3 negatively regulates lipopolysaccharide-induced NF-κB signaling through TRAF6.
  9. The observations suggest a mechanism whereby the BAG6 ubiquitin-linked domain provides a platform for discriminating substrates with shorter hydrophobicity stretches as a signal for defective proteins.
    Title: A conserved island of BAG6/Scythe is related to ubiquitin domains and participates in short hydrophobicity recognition.
  10. we found BAG6 to be dispensable in antigen processing
    Title: Chaperone BAG6 is dispensable for MHC class I antigen processing and presentation.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables misfolded protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables proteasome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-specific protease binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in antigen processing and presentation of peptide antigen via MHC class I TAS
Traceable Author Statement
more info
 PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum stress-induced pre-emptive quality control ISO
Inferred from Sequence Orthology
more info
  
involved_in immune response-activating cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in internal peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lung development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of unfolded protein ISO
Inferred from Sequence Orthology
more info
  
involved_in natural killer cell activation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in post-translational protein targeting to endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasomal protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tail-anchored membrane protein insertion into ER membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of BAT3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BAT3 complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large proline-rich protein BAG6
Names
BAG family molecular chaperone regulator 6
HLA-B-associated transcript 3
large proline-rich protein BAT3
protein Scythe

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252468.2 → NP_001239397.1  large proline-rich protein BAG6 isoform 2

    See identical proteins and their annotated locations for NP_001239397.1

    Status: VALIDATED

    Source sequence(s)
    CR974444
    Consensus CDS
    CCDS57073.1
    UniProtKB/TrEMBL
    G3UYQ2, Q3UF95
    Related
    ENSMUSP00000129324.3, ENSMUST00000166426.9
    Conserved Domains (3) summary
    PRK07764
    Location:909 → 1100
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:260 → 374
    DUF3538; Domain of unknown function (DUF3538)

  2. NM_001252469.2 → NP_001239398.1  large proline-rich protein BAG6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CR974444
    Consensus CDS
    CCDS57072.1
    UniProtKB/TrEMBL
    G3UYQ2, G3UZT6
    Related
    ENSMUSP00000134628.2, ENSMUST00000173550.8
    Conserved Domains (3) summary
    PRK07764
    Location:944 → 1122
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:260 → 374
    DUF3538; Domain of unknown function (DUF3538)

  3. NM_001372260.1 → NP_001359189.1  large proline-rich protein BAG6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
    Conserved Domains (3) summary
    PRK07764
    Location:963 → 1154
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  4. NM_001372261.1 → NP_001359190.1  large proline-rich protein BAG6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
    Conserved Domains (3) summary
    PRK07764
    Location:962 → 1153
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  5. NM_001372262.1 → NP_001359191.1  large proline-rich protein BAG6 isoform 6

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:945 → 1136
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:260 → 374
    DUF3538; Domain of unknown function (DUF3538)

  6. NM_001372265.1 → NP_001359194.1  large proline-rich protein BAG6 isoform 7

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:927 → 1147
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  7. NM_001372266.1 → NP_001359195.1  large proline-rich protein BAG6 isoform 12

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:927 → 1105
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  8. NM_001372267.1 → NP_001359196.1  large proline-rich protein BAG6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/Swiss-Prot
    Q8SNA3, Q9Z1R2
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:927 → 1118
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  9. NM_001372268.1 → NP_001359197.1  large proline-rich protein BAG6 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CR974444
    Consensus CDS
    CCDS28688.1
    UniProtKB/Swiss-Prot
    Q8SNA3, Q9Z1R2
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:927 → 1118
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  10. NM_001372269.1 → NP_001359198.1  large proline-rich protein BAG6 isoform 18

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:926 → 1117
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  11. NM_001372270.1 → NP_001359199.1  large proline-rich protein BAG6 isoform 18

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:926 → 1117
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  12. NM_001372271.1 → NP_001359200.1  large proline-rich protein BAG6 isoform 18

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:926 → 1117
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  13. NM_001372272.1 → NP_001359201.1  large proline-rich protein BAG6 isoform 18

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:926 → 1117
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  14. NM_001372273.1 → NP_001359202.1  large proline-rich protein BAG6 isoform 8

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:926 → 1146
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  15. NM_001372274.1 → NP_001359203.1  large proline-rich protein BAG6 isoform 8

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:926 → 1146
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  16. NM_001372275.1 → NP_001359204.1  large proline-rich protein BAG6 isoform 9

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
    Conserved Domains (3) summary
    PRK07764
    Location:963 → 1141
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  17. NM_001372276.1 → NP_001359205.1  large proline-rich protein BAG6 isoform 10

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
    Conserved Domains (3) summary
    PRK07764
    Location:962 → 1140
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  18. NM_001372277.1 → NP_001359206.1  large proline-rich protein BAG6 isoform 10

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
    Related
    ENSMUSP00000134425.2, ENSMUST00000174281.9
    Conserved Domains (3) summary
    PRK07764
    Location:962 → 1140
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  19. NM_001372278.1 → NP_001359207.1  large proline-rich protein BAG6 isoform 10

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
    Conserved Domains (3) summary
    PRK07764
    Location:962 → 1140
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  20. NM_001372279.1 → NP_001359208.1  large proline-rich protein BAG6 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2, Q3UF95
    Conserved Domains (3) summary
    PRK07764
    Location:909 → 1100
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:260 → 374
    DUF3538; Domain of unknown function (DUF3538)

  21. NM_001372280.1 → NP_001359209.1  large proline-rich protein BAG6 isoform 11

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:908 → 1099
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:260 → 374
    DUF3538; Domain of unknown function (DUF3538)

  22. NM_001372281.1 → NP_001359210.1  large proline-rich protein BAG6 isoform 11

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:908 → 1099
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:260 → 374
    DUF3538; Domain of unknown function (DUF3538)

  23. NM_001372282.1 → NP_001359211.1  large proline-rich protein BAG6 isoform 11

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:908 → 1099
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:260 → 374
    DUF3538; Domain of unknown function (DUF3538)

  24. NM_001372283.1 → NP_001359212.1  large proline-rich protein BAG6 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2, G3UZT6
    Conserved Domains (3) summary
    PRK07764
    Location:944 → 1122
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:260 → 374
    DUF3538; Domain of unknown function (DUF3538)

  25. NM_001372284.1 → NP_001359213.1  large proline-rich protein BAG6 isoform 12

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:927 → 1105
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  26. NM_001372285.1 → NP_001359214.1  large proline-rich protein BAG6 isoform 12

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:927 → 1105
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  27. NM_001372286.1 → NP_001359215.1  large proline-rich protein BAG6 isoform 13

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:926 → 1104
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  28. NM_001372287.1 → NP_001359216.1  large proline-rich protein BAG6 isoform 13

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:926 → 1104
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  29. NM_001372288.1 → NP_001359217.1  large proline-rich protein BAG6 isoform 14

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:926 → 1064
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  30. NM_001372289.1 → NP_001359218.1  large proline-rich protein BAG6 isoform 15

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:908 → 1086
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:260 → 374
    DUF3538; Domain of unknown function (DUF3538)

  31. NM_001372290.1 → NP_001359219.1  large proline-rich protein BAG6 isoform 15

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Related
    ENSMUSP00000134175.2, ENSMUST00000172571.8
    Conserved Domains (3) summary
    PRK07764
    Location:908 → 1086
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:260 → 374
    DUF3538; Domain of unknown function (DUF3538)

  32. NM_001372291.1 → NP_001359220.1  large proline-rich protein BAG6 isoform 16

    Status: VALIDATED

    Source sequence(s)
    CR974444
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:901 → 1079
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  33. NM_001404327.1 → NP_001391256.1  large proline-rich protein BAG6 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CR974444

  34. NM_001404328.1 → NP_001391257.1  large proline-rich protein BAG6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    CR974444

  35. NM_001404329.1 → NP_001391258.1  large proline-rich protein BAG6 isoform 5

    Status: VALIDATED

    Source sequence(s)
    CR974444

  36. NM_001404330.1 → NP_001391259.1  large proline-rich protein BAG6 isoform 17

    Status: VALIDATED

    Source sequence(s)
    CR974444

  37. NM_001404331.1 → NP_001391260.1  large proline-rich protein BAG6 isoform 9

    Status: VALIDATED

    Source sequence(s)
    CR974444

  38. NM_057171.3 → NP_476512.1  large proline-rich protein BAG6 isoform 1

    See identical proteins and their annotated locations for NP_476512.1

    Status: VALIDATED

    Source sequence(s)
    CR974444
    Consensus CDS
    CCDS28688.1
    UniProtKB/Swiss-Prot
    Q8SNA3, Q9Z1R2
    UniProtKB/TrEMBL
    G3UYQ2
    Related
    ENSMUSP00000025250.8, ENSMUST00000025250.14
    Conserved Domains (3) summary
    PRK07764
    Location:927 → 1118
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35354132..35366297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524117.4 → XP_006524180.1  large proline-rich protein BAG6 isoform X9

    See identical proteins and their annotated locations for XP_006524180.1

    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:945 → 1136
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:260 → 374
    DUF3538; Domain of unknown function (DUF3538)

  2. XM_030249713.1 → XP_030105573.1  large proline-rich protein BAG6 isoform X10

    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:944 → 1135
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:260 → 374
    DUF3538; Domain of unknown function (DUF3538)

  3. XM_006524118.4 → XP_006524181.1  large proline-rich protein BAG6 isoform X14

    See identical proteins and their annotated locations for XP_006524181.1

    UniProtKB/TrEMBL
    A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
    Conserved Domains (3) summary
    PRK07764
    Location:1004 → 1195
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:58 → 128
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:319 → 433
    DUF3538; Domain of unknown function (DUF3538)

  4. XM_006524115.3 → XP_006524178.1  large proline-rich protein BAG6 isoform X7

    See identical proteins and their annotated locations for XP_006524178.1

    UniProtKB/TrEMBL
    A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
    Conserved Domains (3) summary
    PRK07764
    Location:1004 → 1182
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:58 → 128
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:319 → 433
    DUF3538; Domain of unknown function (DUF3538)

  5. XM_017317432.2 → XP_017172921.1  large proline-rich protein BAG6 isoform X1

    UniProtKB/TrEMBL
    A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
    Conserved Domains (3) summary
    PRK07764
    Location:1004 → 1224
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:58 → 128
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:319 → 433
    DUF3538; Domain of unknown function (DUF3538)

  6. XM_017317434.2 → XP_017172923.1  large proline-rich protein BAG6 isoform X8

    UniProtKB/TrEMBL
    A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
    Conserved Domains (3) summary
    PRK07764
    Location:1004 → 1142
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:58 → 128
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:319 → 433
    DUF3538; Domain of unknown function (DUF3538)

  7. XM_036160539.1 → XP_036016432.1  large proline-rich protein BAG6 isoform X2

    UniProtKB/TrEMBL
    A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
    Conserved Domains (3) summary
    PRK07764
    Location:1003 → 1223
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:58 → 128
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:319 → 433
    DUF3538; Domain of unknown function (DUF3538)

  8. XM_036160541.1 → XP_036016434.1  large proline-rich protein BAG6 isoform X6

    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:968 → 1188
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:58 → 128
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:319 → 433
    DUF3538; Domain of unknown function (DUF3538)

  9. XM_030249721.1 → XP_030105581.1  large proline-rich protein BAG6 isoform X13

    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:968 → 1106
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:58 → 128
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:319 → 433
    DUF3538; Domain of unknown function (DUF3538)

  10. XM_030249712.2 → XP_030105572.1  large proline-rich protein BAG6 isoform X3

    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:985 → 1176
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:58 → 128
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:301 → 415
    DUF3538; Domain of unknown function (DUF3538)

  11. XM_030249715.2 → XP_030105575.1  large proline-rich protein BAG6 isoform X11

    UniProtKB/Swiss-Prot
    Q8SNA3, Q9Z1R2
    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:927 → 1118
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  12. XM_006524113.4 → XP_006524176.1  large proline-rich protein BAG6 isoform X4

    See identical proteins and their annotated locations for XP_006524176.1

    UniProtKB/TrEMBL
    A0A0A6YYM5, A0A0K0K1E4, G3UZB4, Q3TDL4
    Conserved Domains (3) summary
    PRK07764
    Location:963 → 1154
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:278 → 392
    DUF3538; Domain of unknown function (DUF3538)

  13. XM_030249711.1 → XP_030105571.1  large proline-rich protein BAG6 isoform X9

    UniProtKB/TrEMBL
    G3UYQ2
    Conserved Domains (3) summary
    PRK07764
    Location:945 → 1136
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd01809
    Location:17 → 87
    Ubl_BAG6; ubiquitin-like (Ubl) domain found in BCL2-associated athanogene 6 (BAG6) and similar proteins
    pfam12057
    Location:260 → 374
    DUF3538; Domain of unknown function (DUF3538)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1R2.1 GenPept UniProtKB/Swiss-Prot:Q9Z1R2

Gene LinkOut

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