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Wnt6 wingless-type MMTV integration site family, member 6 [ Mus musculus (house mouse) ]

Gene ID: 22420, updated on 5-Mar-2024

Summary

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Official Symbol
Wnt6provided by MGI
Official Full Name
wingless-type MMTV integration site family, member 6provided by MGI
Primary source
MGI:MGI:98960
See related
Ensembl:ENSMUSG00000033227 AllianceGenome:MGI:98960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wnt-6
Summary
Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within several processes, including epithelial-mesenchymal cell signaling; nephron tubule morphogenesis; and positive regulation of macromolecule metabolic process. Located in cell surface and extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human WNT6 (Wnt family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 26.4), limb E14.5 (RPKM 9.9) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Wnt6 in Genome Data Viewer
Location:
1 C4; 1 38.54 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74793499..74824481)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74754342..74785322)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 27, subfamily a, polypeptide 1 Neighboring gene protein kinase, AMP-activated, gamma 3 non-catalytic subunit Neighboring gene STARR-seq mESC enhancer starr_01342 Neighboring gene predicted gene 29539 Neighboring gene predicted gene, 32099 Neighboring gene STARR-seq mESC enhancer starr_01343 Neighboring gene wingless-type MMTV integration site family, member 10A Neighboring gene VISTA enhancer mm1017 Neighboring gene nuclear encoded tRNA glycine 3 (anticodon GCC)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Wnt6 is expressed in granulomatous lesions of Mycobacterium tuberculosis-infected mice and is involved in macrophage differentiation and proliferation. Schaale K, et al. J Immunol, 2013 Nov 15. PMID 24123681
  2. Wnt6 is essential for stromal cell proliferation during decidualization in mice. Wang Q, et al. Biol Reprod, 2013 Jan. PMID 23175771
  3. Wnt6 induces the specification and epithelialization of F9 embryonal carcinoma cells to primitive endoderm. Krawetz R, et al. Cell Signal, 2008 Mar. PMID 18160257
  4. Wnt 6 regulates the epithelialisation process of the segmental plate mesoderm leading to somite formation. Schmidt C, et al. Dev Biol, 2004 Jul 1. PMID 15196961
  5. Wnt6 plays a complex role in maintaining human limbal stem/progenitor cells. Bonnet C, et al. Sci Rep, 2021 Oct 22. PMID 34686698, Free PMC Article

See all (152) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of TGFbeta1 and WNT6 in FGF2 and BMP4-driven endothelial differentiation of murine embryonic stem cells.
    Title: Role of TGFβ1 and WNT6 in FGF2 and BMP4-driven endothelial differentiation of murine embryonic stem cells.
  2. Wnt6 plays a complex role in maintaining human limbal stem/progenitor cells.
    Title: Wnt6 plays a complex role in maintaining human limbal stem/progenitor cells.
  3. WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis.
    Title: WNT6/ACC2-induced storage of triacylglycerols in macrophages is exploited by Mycobacterium tuberculosis.
  4. Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome.
    Title: Restoring Wnt6 signaling ameliorates behavioral deficits in MeCP2 T158A mouse model of Rett syndrome.
  5. Secreted Wnt6 binds to FZD4 to activate the canonical Wnt6 signaling pathway, which is upstream of ROCK1 and 14-3-3sigma, and that this is the cell signaling pathway underlying diabetes-associated centrosome amplification.
    Title: Secreted Wnt6 mediates diabetes-associated centrosome amplification via its receptor FZD4.
  6. RNA pol III-mediated transcription positively regulates long non-coding RNA H19 and Wnt6 expression, established adipogenesis inhibitors.
    Title: Maf1 and Repression of RNA Polymerase III-Mediated Transcription Drive Adipocyte Differentiation.
  7. Wnt6 signals through the canonical pathway in renal epithelial cells as evidenced by increased phosphorylation of GSK3beta ), nuclear accumulation of beta-catenin and increased TCF/Lef transcriptional activity
    Title: Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis.
  8. A negative feedback loop involving WNT6 and DKK1 attenuates canonical WNT6-beta-catenin signaling, thereby allowing teratocarcinoma cells to differentiate.
    Title: Frizzled gene expression and negative regulation of canonical WNT-β-catenin signaling in mouse F9 teratocarcinoma cells.
  9. Sertoli cells secrete Wnt6 as a paracrine signal for undifferentiated spermatogonia.
    Title: Paracrine Wnt/β-catenin signaling mediates proliferation of undifferentiated spermatogonia in the adult mouse testis.
  10. A novel role of Sfrp2 and Wnt6 in regulating the dynamic process of CPC proliferation and differentiation.
    Title: Inhibition of Wnt6 by Sfrp2 regulates adult cardiac progenitor cell differentiation by differential modulation of Wnt pathways.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within animal organ morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within axis specification IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell-cell signaling TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within epithelial-mesenchymal cell signaling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nephron tubule development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within nephron tubule formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in odontogenesis of dentin-containing tooth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tooth mineralization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein Wnt-6
Names
wingless-related MMTV integration site 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009526.3 → NP_033552.2  protein Wnt-6 precursor

    See identical proteins and their annotated locations for NP_033552.2

    Status: VALIDATED

    Source sequence(s)
    AK133954, AV303464, M89800
    Consensus CDS
    CCDS15056.1
    UniProtKB/Swiss-Prot
    P22727, Q80ZM9
    Related
    ENSMUSP00000006716.7, ENSMUST00000006716.8
    Conserved Domains (1) summary
    cd19338
    Location:34 → 364
    Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74793499..74824481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495887.4 → XP_006495950.1  protein Wnt-6 isoform X1

    See identical proteins and their annotated locations for XP_006495950.1

    UniProtKB/Swiss-Prot
    P22727, Q80ZM9
    Conserved Domains (1) summary
    cd19338
    Location:34 → 364
    Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins

  2. XM_006495888.4 → XP_006495951.1  protein Wnt-6 isoform X1

    See identical proteins and their annotated locations for XP_006495951.1

    UniProtKB/Swiss-Prot
    P22727, Q80ZM9
    Conserved Domains (1) summary
    cd19338
    Location:34 → 364
    Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins

  3. XM_006495889.3 → XP_006495952.1  protein Wnt-6 isoform X2

    Conserved Domains (1) summary
    cd19338
    Location:1 → 331
    Wnt_Wnt6; Wnt domain found in protein Wnt-6 and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P22727.2 GenPept UniProtKB/Swiss-Prot:P22727

Gene LinkOut

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