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Senp1 SUMO1/sentrin specific peptidase 1 [ Mus musculus (house mouse) ]

Gene ID: 223870, updated on 21-Apr-2024

Summary

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Official Symbol
Senp1provided by MGI
Official Full Name
SUMO1/sentrin specific peptidase 1provided by MGI
Primary source
MGI:MGI:2445054
See related
Ensembl:ENSMUSG00000033075 AllianceGenome:MGI:2445054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
suPr-2; D15Ertd528e; 2310046A20Rik; E330036L07Rik
Summary
Enables SUMO-specific isopeptidase activity. Acts upstream of or within negative regulation of proteasomal ubiquitin-dependent protein catabolic process; protein desumoylation; and regulation of definitive erythrocyte differentiation. Predicted to be located in focal adhesion; nuclear membrane; and nucleoplasm. Predicted to be active in nucleus. Is expressed in embryo and heart. Used to study type 1 diabetes mellitus. Orthologous to human SENP1 (SUMO specific peptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 9.4), thymus adult (RPKM 9.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 F1; 15 54.04 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (97936625..97991625, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98038744..98093569, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene collagen, type II, alpha 1 Neighboring gene predicted gene, 46536 Neighboring gene predicted gene, 41395 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:97898039-97898148 Neighboring gene STARR-seq mESC enhancer starr_39649 Neighboring gene predicted gene, 25668 Neighboring gene STARR-positive B cell enhancer ABC_E10879 Neighboring gene STARR-positive B cell enhancer ABC_E5514 Neighboring gene STARR-seq mESC enhancer starr_39650 Neighboring gene STARR-seq mESC enhancer starr_39651 Neighboring gene phosphofructokinase, muscle Neighboring gene STARR-seq mESC enhancer starr_39652 Neighboring gene STARR-seq mESC enhancer starr_39654 Neighboring gene ankyrin repeat and SOCS box-containing 8 Neighboring gene STARR-positive B cell enhancer ABC_E5515 Neighboring gene coiled-coil domain containing 184

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SENP1 modulates chronic intermittent hypoxia-induced inflammation of microglia and neuronal injury by inhibiting TOM1 pathway. Wang H, et al. Int Immunopharmacol, 2023 Jun. PMID 37137262
  2. SENP1 protects cisplatin-induced AKI by attenuating apoptosis through regulation of HIF-1α. Wang L, et al. Exp Cell Res, 2022 Oct 1. PMID 35839862
  3. SENP1 regulates the transformation of lung resident mesenchymal stem cells and is associated with idiopathic pulmonary fibrosis progression. Sun W, et al. Cell Commun Signal, 2022 Jul 14. PMID 35836260, Free PMC Article
  4. Ginkgolic acid improves bleomycin-induced pulmonary fibrosis by inhibiting SMAD4 SUMOylation. Yu L, et al. Oxid Med Cell Longev, 2022. PMID 35707278, Free PMC Article
  5. Role of pericyte-derived SENP1 in neuronal injury after brain ischemia. Sun M, et al. CNS Neurosci Ther, 2020 Aug. PMID 32495523, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SENP1 attenuates hypoxia-reoxygenation injury in liver sinusoid endothelial cells by relying on the HIF-1alpha signaling pathway.
    Title: SENP1 attenuates hypoxia‑reoxygenation injury in liver sinusoid endothelial cells by relying on the HIF‑1α signaling pathway.
  2. A role and mechanism for redox sensing by SENP1 in beta-cell responses to high fat feeding.
    Title: A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding.
  3. Aberrant SUMO2/3 modification of RUNX1 upon SENP1 inhibition is linked to the development of diabetic retinopathy in mice.
    Title: Aberrant SUMO2/3 modification of RUNX1 upon SENP1 inhibition is linked to the development of diabetic retinopathy in mice.
  4. FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation.
    Title: FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation.
  5. SENP1 modulates chronic intermittent hypoxia-induced inflammation of microglia and neuronal injury by inhibiting TOM1 pathway.
    Title: SENP1 modulates chronic intermittent hypoxia-induced inflammation of microglia and neuronal injury by inhibiting TOM1 pathway.
  6. Transcription factor YY1 mediates self-renewal of glioblastoma stem cells through regulation of the SENP1/METTL3/MYC axis.
    Title: Transcription factor YY1 mediates self-renewal of glioblastoma stem cells through regulation of the SENP1/METTL3/MYC axis.
  7. Leptin accelerates BMSC transformation into vertebral epiphyseal plate chondrocytes by activating SENP1-mediated deSUMOylation of SIRT3.
    Title: Leptin accelerates BMSC transformation into vertebral epiphyseal plate chondrocytes by activating SENP1-mediated deSUMOylation of SIRT3.
  8. SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation.
    Title: SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation.
  9. SENP1 Protects Against Pressure Overload-Induced Cardiac Remodeling and Dysfunction Via Inhibiting STAT3 Signaling.
    Title: SENP1 Protects Against Pressure Overload-Induced Cardiac Remodeling and Dysfunction Via Inhibiting STAT3 Signaling.
  10. SENP1 protects cisplatin-induced AKI by attenuating apoptosis through regulation of HIF-1alpha.
    Title: SENP1 protects cisplatin-induced AKI by attenuating apoptosis through regulation of HIF-1α.
Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC27975

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO-specific endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables deSUMOylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deSUMOylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deSUMOylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein desumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein desumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein desumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein desumoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein desumoylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of definitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sentrin-specific protease 1
Names
SUMO-1 protease 2
SUMO1/sentrin specific protease 1
sentrin/SUMO-specific protease SENP1
NP_001366502.1
NP_659100.1
XP_006520943.1
XP_006520945.1
XP_006520946.1
XP_006520947.1
XP_030104385.1
XP_030104386.1
XP_036015277.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379573.1 → NP_001366502.1  sentrin-specific protease 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC113444
    Conserved Domains (2) summary
    PRK04863
    Location:381 → 475
    mukB; chromosome partition protein MukB
    cl23802
    Location:448 → 670
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  2. NM_144851.5 → NP_659100.1  sentrin-specific protease 1 isoform 2

    See identical proteins and their annotated locations for NP_659100.1

    Status: VALIDATED

    Source sequence(s)
    AK009838, AK028565, AK054521, AW490919, BF453574, CX203962
    Consensus CDS
    CCDS49717.1
    UniProtKB/Swiss-Prot
    P59110, Q8BTV5, Q8BZF1
    Related
    ENSMUSP00000046598.9, ENSMUST00000044189.16
    Conserved Domains (1) summary
    cl23802
    Location:416 → 638
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    97936625..97991625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520882.5 → XP_006520945.1  sentrin-specific protease 1 isoform X2

    UniProtKB/TrEMBL
    M0QWX4
    Related
    ENSMUSP00000138056.2, ENSMUST00000180657.2
    Conserved Domains (2) summary
    PRK04863
    Location:375 → 469
    mukB; chromosome partition protein MukB
    cl23802
    Location:442 → 664
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  2. XM_006520884.5 → XP_006520947.1  sentrin-specific protease 1 isoform X4

    Conserved Domains (1) summary
    COG5160
    Location:259 → 498
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  3. XM_006520883.3 → XP_006520946.1  sentrin-specific protease 1 isoform X3

    Conserved Domains (2) summary
    COG5160
    Location:285 → 524
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    PRK04863
    Location:233 → 327
    mukB; chromosome partition protein MukB

  4. XM_006520880.3 → XP_006520943.1  sentrin-specific protease 1 isoform X1

    Conserved Domains (2) summary
    PRK04863
    Location:407 → 501
    mukB; chromosome partition protein MukB
    cl23802
    Location:474 → 696
    Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

  5. XM_030248526.1 → XP_030104386.1  sentrin-specific protease 1 isoform X4

    Conserved Domains (1) summary
    COG5160
    Location:259 → 498
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

  6. XM_030248525.1 → XP_030104385.1  sentrin-specific protease 1 isoform X3

    Conserved Domains (2) summary
    COG5160
    Location:285 → 524
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
    PRK04863
    Location:233 → 327
    mukB; chromosome partition protein MukB

  7. XM_036159384.1 → XP_036015277.1  sentrin-specific protease 1 isoform X4

    Conserved Domains (1) summary
    COG5160
    Location:259 → 498
    ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59110.1 GenPept UniProtKB/Swiss-Prot:P59110

Gene LinkOut

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