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Tmem184b transmembrane protein 184b [ Mus musculus (house mouse) ]

Gene ID: 223693, updated on 12-May-2024

Summary

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Official Symbol
Tmem184bprovided by MGI
Official Full Name
transmembrane protein 184bprovided by MGI
Primary source
MGI:MGI:2445179
See related
Ensembl:ENSMUSG00000009035 AllianceGenome:MGI:2445179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610507A11; 4732495E13Rik
Summary
Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system gland; nervous system; and reproductive system. Orthologous to human TMEM184B (transmembrane protein 184B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 33.0), adrenal adult (RPKM 25.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 37.7 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79244884..79287503, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79360684..79403303, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group VI Neighboring gene STARR-positive B cell enhancer ABC_E7389 Neighboring gene predicted gene 20420 Neighboring gene STARR-positive B cell enhancer ABC_E1913 Neighboring gene STARR-seq mESC enhancer starr_39174 Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) Neighboring gene microRNA 1943 Neighboring gene STARR-seq mESC enhancer starr_39180 Neighboring gene STARR-seq mESC enhancer starr_39181 Neighboring gene casein kinase 1, epsilon Neighboring gene predicted gene 16059 Neighboring gene STARR-seq mESC enhancer starr_39185 Neighboring gene STARR-seq mESC enhancer starr_39186 Neighboring gene predicted gene, 41359

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance. Bhattacharya MR, et al. J Neurosci, 2016 Apr 27. PMID 27122027, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transmembrane protein 184B (TMEM184B) promotes expression of synaptic gene networks in the mouse hippocampus.
    Title: Transmembrane protein 184B (TMEM184B) promotes expression of synaptic gene networks in the mouse hippocampus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transmembrane protein 184B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253817.1 → NP_001240746.1  transmembrane protein 184B isoform 1

    See identical proteins and their annotated locations for NP_001240746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1) .
    Source sequence(s)
    BC046959, CO812629
    Consensus CDS
    CCDS27639.1
    UniProtKB/Swiss-Prot
    Q3TY97, Q8BG09, Q8BJ02
    Related
    ENSMUSP00000136416.2, ENSMUST00000178522.3
    Conserved Domains (1) summary
    pfam03619
    Location:46 → 317
    Solute_trans_a; Organic solute transporter Ostalpha

  2. NM_001253819.1 → NP_001240748.1  transmembrane protein 184B isoform 2

    See identical proteins and their annotated locations for NP_001240748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) is longer than isoform 1.
    Source sequence(s)
    AA240987, AK048138, BY152403
    Consensus CDS
    CCDS88803.1
    UniProtKB/TrEMBL
    A0A2I3BQI5
    Related
    ENSMUSP00000154210.2, ENSMUST00000228002.2
    Conserved Domains (1) summary
    pfam03619
    Location:46 → 317
    Solute_trans_a; Organic solute transporter Ostalpha

  3. NM_001253820.1 → NP_001240749.1  transmembrane protein 184B isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two exons in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AK149366, CX239857
    UniProtKB/TrEMBL
    A0A2R8VI00
    Conserved Domains (1) summary
    pfam03619
    Location:9 → 177
    Solute_trans_a; Organic solute transporter Ostalpha

  4. NM_001378998.1 → NP_001365927.1  transmembrane protein 184B isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC165278
    Conserved Domains (1) summary
    pfam03619
    Location:75 → 346
    Solute_trans_a; Organic solute transporter Ostalpha

  5. NM_172608.1 → NP_766196.1  transmembrane protein 184B isoform 1

    See identical proteins and their annotated locations for NP_766196.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the predominant transcript and encodes a 407aa isoform (1).
    Source sequence(s)
    AA240987, AK029129, BY275319
    Consensus CDS
    CCDS27639.1
    UniProtKB/Swiss-Prot
    Q3TY97, Q8BG09, Q8BJ02
    Related
    ENSMUSP00000074518.3, ENSMUST00000074991.10
    Conserved Domains (1) summary
    pfam03619
    Location:46 → 317
    Solute_trans_a; Organic solute transporter Ostalpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79244884..79287503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159354.1 → XP_036015247.1  transmembrane protein 184B isoform X6

    UniProtKB/TrEMBL
    A0A2R8VI00
    Related
    ENSMUSP00000155585.2, ENSMUST00000231076.2
    Conserved Domains (1) summary
    pfam03619
    Location:18 → 177
    Solute_trans_a; Organic solute transporter Ostalpha

  2. XM_006520805.4 → XP_006520868.1  transmembrane protein 184B isoform X1

    Conserved Domains (1) summary
    pfam03619
    Location:75 → 346
    Solute_trans_a; Organic solute transporter Ostalpha

  3. XM_036159353.1 → XP_036015246.1  transmembrane protein 184B isoform X3

    UniProtKB/Swiss-Prot
    Q3TY97, Q8BG09, Q8BJ02
    Conserved Domains (1) summary
    pfam03619
    Location:46 → 317
    Solute_trans_a; Organic solute transporter Ostalpha

  4. XM_006520806.4 → XP_006520869.1  transmembrane protein 184B isoform X2

    See identical proteins and their annotated locations for XP_006520869.1

    UniProtKB/TrEMBL
    A0A2I3BQI5
    Conserved Domains (1) summary
    pfam03619
    Location:46 → 317
    Solute_trans_a; Organic solute transporter Ostalpha

  5. XM_030248501.2 → XP_030104361.1  transmembrane protein 184B isoform X5

    Conserved Domains (1) summary
    pfam03619
    Location:33 → 231
    Solute_trans_a; Organic solute transporter Ostalpha

  6. XM_006520807.5 → XP_006520870.1  transmembrane protein 184B isoform X4

    Conserved Domains (1) summary
    pfam03619
    Location:1 → 251
    Solute_trans_a; Organic solute transporter Ostalpha

  7. XM_006520810.4 → XP_006520873.1  transmembrane protein 184B isoform X7

    Conserved Domains (1) summary
    pfam03619
    Location:23 → 165
    Solute_trans_a; Organic solute transporter Ostalpha
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG09.1 GenPept UniProtKB/Swiss-Prot:Q8BG09

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