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Vrk1 vaccinia related kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 22367, updated on 16-Apr-2024

Summary

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Official Symbol
Vrk1provided by MGI
Official Full Name
vaccinia related kinase 1provided by MGI
Primary source
MGI:MGI:1261847
See related
Ensembl:ENSMUSG00000021115 AllianceGenome:MGI:1261847
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
51PK; Gm40568; Gm46378
Summary
Enables protein serine/threonine kinase activity. Acts upstream of or within protein autophosphorylation. Located in nucleus. Is expressed in several structures, including dorsal mesogastrium; hemolymphoid system; liver; metanephros; and yolk sac. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 11.6), CNS E11.5 (RPKM 9.0) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 E- F1; 12 56.37 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (105976398..106044578)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (106010139..106078318)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33194 Neighboring gene poly (A) polymerase alpha Neighboring gene STARR-seq mESC enhancer starr_33197 Neighboring gene predicted gene, 19554 Neighboring gene predicted gene, 32370 Neighboring gene STARR-seq mESC enhancer starr_33198 Neighboring gene VISTA enhancer mm1604 Neighboring gene STARR-positive B cell enhancer ABC_E7178 Neighboring gene STARR-positive B cell enhancer ABC_E3067 Neighboring gene STARR-seq mESC enhancer starr_33203 Neighboring gene predicted gene, 32723 Neighboring gene predicted gene, 32635 Neighboring gene STARR-seq mESC enhancer starr_33204 Neighboring gene predicted gene, 32776

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Vrk1 partial Knockdown in Mice Results in Reduced Brain Weight and Mild Motor Dysfunction, and Indicates Neuronal VRK1 Target Pathways. Vinograd-Byk H, et al. Sci Rep, 2018 Jul 26. PMID 30050127, Free PMC Article
  2. Defective folliculogenesis in female mice lacking Vaccinia-related kinase 1. Kim J, et al. Sci Rep, 2012. PMID 22741057, Free PMC Article
  3. HnRNP A1 phosphorylated by VRK1 stimulates telomerase and its binding to telomeric DNA sequence. Choi YH, et al. Nucleic Acids Res, 2012 Sep 1. PMID 22740652, Free PMC Article
  4. Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia. Wiebe MS, et al. Biol Reprod, 2010 Jan. PMID 19696012, Free PMC Article
  5. Ginsenoside Rg3 regulates DNA damage in non-small cell lung cancer cells by activating VRK1/P53BP1 pathway. Liu T, et al. Biomed Pharmacother, 2019 Dec. PMID 31629252

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VRK1 promotes DNA-induced type I interferon production.
    Title: VRK1 promotes DNA-induced type I interferon production.
  2. Ginsenoside Rg3 upregulate VRK1 expression and P53BP1 foci formation in response to DNA damage.
    Title: Ginsenoside Rg3 regulates DNA damage in non-small cell lung cancer cells by activating VRK1/P53BP1 pathway.
  3. Together, these studies of the partial KO Vrk1 mice reveal that even moderately reduced levels of Vrk1 expression result in minor neurological impairment and indicate new neuronal pathways likely involving VRK1.
    Title: Vrk1 partial Knockdown in Mice Results in Reduced Brain Weight and Mild Motor Dysfunction, and Indicates Neuronal VRK1 Target Pathways.
  4. VRK1 self-represses its activity to phosphorylate PXR through cyclin-dependent kinase 2 (CDK2) in high glucose conditions, resulting in the repression of the PCK1 gene. This PXR phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2-PXR-PP2Calpha-SGK2 pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.
    Title: Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal.
  5. VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP). APP overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP-dependent mechanism.
    Title: The spinal muscular atrophy with pontocerebellar hypoplasia gene VRK1 regulates neuronal migration through an amyloid-β precursor protein-dependent mechanism.
  6. Data suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system.
    Title: Defective folliculogenesis in female mice lacking Vaccinia-related kinase 1.
  7. Protein kinase Cdelta regulates phosphorylation and down-regulation of Vaccinia-related kinase 1 (VRK1), thereby contributing to cell cycle arrest and apoptotic cell death in a p53-dependent manner.
    Title: Protein kinase Cδ regulates vaccinia-related kinase 1 in DNA damage-induced apoptosis.
  8. reduction of VRK1 activity causes a delay in meiotic progression during oogenesis
    Title: The kinase VRK1 is required for normal meiotic progression in mammalian oogenesis.
  9. VRK1 is required for the proliferation and differentiation of undifferentiated spermatogonia, which are essential for spermatogenic cell maintenance
    Title: Vaccinia-related kinase 1 is required for the maintenance of undifferentiated spermatogonia in mouse male germ cells.
  10. Depletion of VRK1 leads to progressive male infertility as a result of a cessation of spermatogonial proliferation.
    Title: Mice deficient in the serine/threonine protein kinase VRK1 are infertile due to a progressive loss of spermatogonia.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3) 
  • Endonuclease-mediated (5) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H3S10 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3T3 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi disassembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein localization to chromatin ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase VRK1
Names
serine/threonine-protein kinase 51PK
NP_001025014.1
NP_001025015.1
NP_001351294.1
NP_001351296.1
NP_001351297.1
NP_001409909.1
NP_035835.1
XP_006515872.1
XP_006515873.1
XP_006515874.1
XP_011242406.1
XP_017170534.1
XP_030102545.1
XP_030102546.1
XP_030102547.1
XP_030102548.1
XP_030102549.1
XP_030102550.1
XP_030102551.1
XP_030102553.1
XP_030102554.1
XP_030102556.1
XP_036013274.1
XP_036013275.1
XP_036013276.1
XP_036013277.1
XP_036013278.1
XP_036013279.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029843.2 → NP_001025014.1  serine/threonine-protein kinase VRK1 isoform b

    See identical proteins and their annotated locations for NP_001025014.1

    Status: VALIDATED

    Source sequence(s)
    AK032344, AV567830, BY130767
    Consensus CDS
    CCDS26157.1
    UniProtKB/TrEMBL
    Q3TL56, Q3UWH3
    Related
    ENSMUSP00000082101.5, ENSMUST00000085026.12
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  2. NM_001029844.2 → NP_001025015.1  serine/threonine-protein kinase VRK1 isoform c

    See identical proteins and their annotated locations for NP_001025015.1

    Status: VALIDATED

    Source sequence(s)
    AK032344, AV567830, BY130767
    Consensus CDS
    CCDS26158.1
    UniProtKB/TrEMBL
    Q3TL56
    Related
    ENSMUSP00000071922.6, ENSMUST00000072040.7
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  3. NM_001364365.1 → NP_001351294.1  serine/threonine-protein kinase VRK1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC144543, AC163040
    Consensus CDS
    CCDS26158.1
    UniProtKB/TrEMBL
    Q3TL56
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  4. NM_001364367.1 → NP_001351296.1  serine/threonine-protein kinase VRK1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC144543, AC163040
    Consensus CDS
    CCDS36551.1
    UniProtKB/Swiss-Prot
    O88635, O88636, Q80X41, Q8C2P7, Q91YH9
    UniProtKB/TrEMBL
    Q3TL56
    Related
    ENSMUSP00000152109.2, ENSMUST00000220629.2
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  5. NM_001364368.1 → NP_001351297.1  serine/threonine-protein kinase VRK1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC144543, AC163040
    UniProtKB/TrEMBL
    Q3TL56
    Conserved Domains (1) summary
    cd14122
    Location:26 → 324
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  6. NM_001422980.1 → NP_001409909.1  serine/threonine-protein kinase VRK1 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC144543, AC163040

  7. NM_011705.4 → NP_035835.1  serine/threonine-protein kinase VRK1 isoform a

    See identical proteins and their annotated locations for NP_035835.1

    Status: VALIDATED

    Source sequence(s)
    AK032344, AV567830, BB749810, BY130767
    Consensus CDS
    CCDS36551.1
    UniProtKB/Swiss-Prot
    O88635, O88636, Q80X41, Q8C2P7, Q91YH9
    UniProtKB/TrEMBL
    Q3TL56
    Related
    ENSMUSP00000021539.9, ENSMUST00000021539.16
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    105976398..106044578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246689.1 → XP_030102549.1  serine/threonine-protein kinase VRK1 isoform X6

    UniProtKB/TrEMBL
    Q3TL56
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  2. XM_006515810.5 → XP_006515873.1  serine/threonine-protein kinase VRK1 isoform X2

    See identical proteins and their annotated locations for XP_006515873.1

    UniProtKB/Swiss-Prot
    O88635, O88636, Q80X41, Q8C2P7, Q91YH9
    UniProtKB/TrEMBL
    Q3TL56
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  3. XM_030246687.2 → XP_030102547.1  serine/threonine-protein kinase VRK1 isoform X4

    UniProtKB/TrEMBL
    Q3TL56, Q3UWH3
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  4. XM_036157384.1 → XP_036013277.1  serine/threonine-protein kinase VRK1 isoform X8

    Conserved Domains (1) summary
    cl21453
    Location:26 → 206
    PKc_like; Protein Kinases, catalytic domain

  5. XM_030246693.2 → XP_030102553.1  serine/threonine-protein kinase VRK1 isoform X8

    Conserved Domains (1) summary
    cl21453
    Location:26 → 206
    PKc_like; Protein Kinases, catalytic domain

  6. XM_006515811.5 → XP_006515874.1  serine/threonine-protein kinase VRK1 isoform X2

    See identical proteins and their annotated locations for XP_006515874.1

    UniProtKB/Swiss-Prot
    O88635, O88636, Q80X41, Q8C2P7, Q91YH9
    UniProtKB/TrEMBL
    Q3TL56
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  7. XM_030246688.2 → XP_030102548.1  serine/threonine-protein kinase VRK1 isoform X5

    UniProtKB/TrEMBL
    Q3TL56
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  8. XM_036157382.1 → XP_036013275.1  serine/threonine-protein kinase VRK1 isoform X4

    UniProtKB/TrEMBL
    Q3TL56, Q3UWH3
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  9. XM_030246685.2 → XP_030102545.1  serine/threonine-protein kinase VRK1 isoform X3

    UniProtKB/TrEMBL
    A0A1Y7VMH3
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  10. XM_030246694.2 → XP_030102554.1  serine/threonine-protein kinase VRK1 isoform X10

    Conserved Domains (1) summary
    cl21453
    Location:26 → 206
    PKc_like; Protein Kinases, catalytic domain

  11. XM_036157385.1 → XP_036013278.1  serine/threonine-protein kinase VRK1 isoform X11

    Conserved Domains (1) summary
    cl21453
    Location:26 → 206
    PKc_like; Protein Kinases, catalytic domain

  12. XM_030246690.2 → XP_030102550.1  serine/threonine-protein kinase VRK1 isoform X6

    UniProtKB/TrEMBL
    Q3TL56
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  13. XM_030246696.2 → XP_030102556.1  serine/threonine-protein kinase VRK1 isoform X11

    Conserved Domains (1) summary
    cl21453
    Location:26 → 206
    PKc_like; Protein Kinases, catalytic domain

  14. XM_036157383.1 → XP_036013276.1  serine/threonine-protein kinase VRK1 isoform X4

    UniProtKB/TrEMBL
    Q3TL56, Q3UWH3
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  15. XM_006515809.3 → XP_006515872.1  serine/threonine-protein kinase VRK1 isoform X2

    See identical proteins and their annotated locations for XP_006515872.1

    UniProtKB/Swiss-Prot
    O88635, O88636, Q80X41, Q8C2P7, Q91YH9
    UniProtKB/TrEMBL
    Q3TL56
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  16. XM_030246686.1 → XP_030102546.1  serine/threonine-protein kinase VRK1 isoform X4

    UniProtKB/TrEMBL
    Q3TL56, Q3UWH3
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  17. XM_030246691.1 → XP_030102551.1  serine/threonine-protein kinase VRK1 isoform X6

    UniProtKB/TrEMBL
    Q3TL56
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  18. XM_036157381.1 → XP_036013274.1  serine/threonine-protein kinase VRK1 isoform X2

    UniProtKB/Swiss-Prot
    O88635, O88636, Q80X41, Q8C2P7, Q91YH9
    UniProtKB/TrEMBL
    Q3TL56
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  19. XM_017315045.3 → XP_017170534.1  serine/threonine-protein kinase VRK1 isoform X1

    UniProtKB/TrEMBL
    Q3TL56
    Conserved Domains (1) summary
    cd14122
    Location:26 → 326
    STKc_VRK1; Catalytic domain of the Serine/Threonine protein kinase, Vaccinia Related Kinase 1

  20. XM_011244104.2 → XP_011242406.1  serine/threonine-protein kinase VRK1 isoform X9

    Conserved Domains (1) summary
    cl21453
    Location:1 → 198
    PKc_like; Protein Kinases, catalytic domain

  21. XM_036157386.1 → XP_036013279.1  serine/threonine-protein kinase VRK1 isoform X12

    UniProtKB/TrEMBL
    Q8CA60
    Conserved Domains (1) summary
    cl21453
    Location:1 → 198
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80X41.2 GenPept UniProtKB/Swiss-Prot:Q80X41

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