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Vcam1 vascular cell adhesion molecule 1 [ Mus musculus (house mouse) ]

Gene ID: 22329, updated on 11-Apr-2024

Summary

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Official Symbol
Vcam1provided by MGI
Official Full Name
vascular cell adhesion molecule 1provided by MGI
Primary source
MGI:MGI:98926
See related
Ensembl:ENSMUSG00000027962 AllianceGenome:MGI:98926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD106; Vcam-1
Summary
Predicted to enable integrin binding activity and primary amine oxidase activity. Acts upstream of or within several processes, including cellular response to glucose stimulus; chorio-allantoic fusion; and heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in apical plasma membrane. Is expressed in several structures, including brain; embryo mesenchyme; extraembryonic component; heart; and hemolymphoid system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human VCAM1 (vascular cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E18 (RPKM 27.1), limb E14.5 (RPKM 20.2) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Vcam1 in Genome Data Viewer
Location:
3 G1; 3 50.17 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (115903669..115923337, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (116110020..116129688, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26344 Neighboring gene predicted gene, 31384 Neighboring gene STARR-seq mESC enhancer starr_08768 Neighboring gene RIKEN cDNA 5330425B07 gene Neighboring gene predicted gene, 26544

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of the Role of Stellate Cell VCAM-1 in NASH Models in Mice. Chung KJ, et al. Int J Mol Sci, 2023 Mar 2. PMID 36902241, Free PMC Article
  2. Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis. Guo Q, et al. Front Immunol, 2022. PMID 36091042, Free PMC Article
  3. Improved impedance to maladaptation and enhanced VCAM-1 upregulation with resistance-type training in the long-lived Snell dwarf (Pit1(dw/dw)) mouse. Rader EP, et al. Aging (Albany NY), 2022 Feb 3. PMID 35113807, Free PMC Article
  4. Membrane-bound SCF and VCAM-1 synergistically regulate the morphology of hematopoietic stem cells. Hao J, et al. J Cell Biol, 2021 Oct 4. PMID 34402812, Free PMC Article
  5. Cellular senescence promotes endothelial activation through epigenetic alteration, and consequently accelerates atherosclerosis. Honda S, et al. Sci Rep, 2021 Jul 16. PMID 34272458, Free PMC Article

See all (359) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Diabetic Endothelial Cell Glycogen Synthase Kinase 3beta Activation Induces VCAM1 Ectodomain Shedding.
    Title: Diabetic Endothelial Cell Glycogen Synthase Kinase 3β Activation Induces VCAM1 Ectodomain Shedding.
  2. MicroRNA-149 improves osteoarthritis via repression of VCAM-1 and inactivation of PI3K/AKT pathway.
    Title: MicroRNA-149 improves osteoarthritis via repression of VCAM-1 and inactivation of PI3K/AKT pathway.
  3. EPSTI1 promotes monocyte adhesion to endothelial cells in vitro via upregulating VCAM-1 and ICAM-1 expression.
    Title: EPSTI1 promotes monocyte adhesion to endothelial cells in vitro via upregulating VCAM-1 and ICAM-1 expression.
  4. Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis.
    Title: Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis.
  5. Improved impedance to maladaptation and enhanced VCAM-1 upregulation with resistance-type training in the long-lived Snell dwarf (Pit1(dw/dw)) mouse.
    Title: Improved impedance to maladaptation and enhanced VCAM-1 upregulation with resistance-type training in the long-lived Snell dwarf (Pit1(dw/dw)) mouse.
  6. Role of enhancer of zeste homolog 2 in osteoclast formation and periodontitis development by downregulating microRNA-101-regulated VCAM-1.
    Title: Role of enhancer of zeste homolog 2 in osteoclast formation and periodontitis development by downregulating microRNA-101-regulated VCAM-1.
  7. Blocking VCAM-1 inhibits pancreatic tumour progression and cancer-associated thrombosis/thromboembolism.
    Title: Blocking VCAM-1 inhibits pancreatic tumour progression and cancer-associated thrombosis/thromboembolism.
  8. Radial Glial Cell-Derived VCAM1 Regulates Cortical Angiogenesis Through Distinct Enrichments in the Proximal and Distal Radial Processes.
    Title: Radial Glial Cell-Derived VCAM1 Regulates Cortical Angiogenesis Through Distinct Enrichments in the Proximal and Distal Radial Processes.
  9. VCAM1-alpha4beta1 integrin interaction mediates interstitial tissue reconstruction in 3-D re-aggregate culture of dissociated prepubertal mouse testicular cells.
    Title: VCAM1-α4β1 integrin interaction mediates interstitial tissue reconstruction in 3-D re-aggregate culture of dissociated prepubertal mouse testicular cells.
  10. Poldip2 controls leukocyte infiltration into the ischemic brain by regulating focal adhesion kinase-mediated VCAM-1 induction.
    Title: Poldip2 controls leukocyte infiltration into the ischemic brain by regulating focal adhesion kinase-mediated VCAM-1 induction.
Submit: New GeneRIF Correction See all GeneRIFs (151)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion mediator activity ISO
Inferred from Sequence Orthology
more info
  
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables primary amine oxidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in amine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium-mediated signaling using intracellular calcium source ISO
Inferred from Sequence Orthology
more info
  
involved_in cardiac neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion in response to extracellular stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within chorio-allantoic fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryonic placenta morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in innervation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in leukocyte tethering or rolling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in visceral serous pericardium development TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in filopodium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in podosome ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
vascular cell adhesion protein 1
Names
V-CAM 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011693.3 → NP_035823.3  vascular cell adhesion protein 1 precursor

    See identical proteins and their annotated locations for NP_035823.3

    Status: VALIDATED

    Source sequence(s)
    AC108909
    Consensus CDS
    CCDS17785.1
    UniProtKB/Swiss-Prot
    P29533
    UniProtKB/TrEMBL
    Q3TR98, Q3UPN1
    Related
    ENSMUSP00000029574.9, ENSMUST00000029574.13
    Conserved Domains (5) summary
    cd07689
    Location:404 → 502
    Ig2_VCAM-1; Second immunoglobulin (Ig)-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1, CD106) and intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    smart00408
    Location:238 → 298
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:321 → 400
    IG_like; Immunoglobulin like
    pfam13895
    Location:514 → 596
    Ig_2; Immunoglobulin domain
    cl11960
    Location:598 → 685
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    115903669..115923337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P29533.1 GenPept UniProtKB/Swiss-Prot:P29533

Gene LinkOut

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