Vav2 vav 2 oncogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vav2provided by MGI
Official Full Name: vav 2 oncogeneprovided by MGI
Primary source: MGI:MGI:102718
See related: Ensembl:ENSMUSG00000009621 AllianceGenome:MGI:102718
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Vav-2; 2810040F13Rik
Summary: This gene encodes a member of the Vav family of Rho guanine nucleotide exchange factors. Vav family proteins are involved in the development and activation of lymphocytes, and the encoded protein may also be involved in angiogenesis. Disruption of this gene in mice is associated with heart, artery, and kidney defects, as well as tachycardia and hypertension. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Expression: Ubiquitous expression in spleen adult (RPKM 23.7), duodenum adult (RPKM 17.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 19.36 cM

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (27152116..27317620, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (27262104..27427608, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function.
Title: The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function.
Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor.
Title: Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor.
Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis.
Title: Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis.
VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma.
Title: VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma.
reduction of VAV2 in absence of CUX1 was associated with a significant decrease of RAC1 activity in response to epithelial wounding. Our results identify a novel pathway by which CUX1 regulates normal intestinal epithelial cell restitution
Title: Transcription factor CUX1 is required for intestinal epithelial wound healing and targets the VAV2-RAC1 Signalling complex.
This inhibitory action of Vav2 shRNA on Hcys-induced podocyte injury was associated with reduction of Rac1 activity and ROS production. These results suggest that elevated Hcys levels activate Vav2 and thereby increase NOX activity leading to ROS production, which triggers NLRP3 inflammasome activation, podocyte dysfunction and glomerular injury.
Title: Contribution of guanine nucleotide exchange factor Vav2 to NLRP3 inflammasome activation in mouse podocytes during hyperhomocysteinemia.
Results show that Vav2 and Rac1 are commonly involved in blood pressure regulation.
Title: Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells.
Data demonstrate that the co-expression of the exchange factors Vav2 and Vav3 is critical for the development of this tumor type.
Title: The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops.
Vav2 and Vav3 are required for normal peripheral nerve degeneration/regeneration, revascularization and functional recovery.
Title: Vav deficiency impedes peripheral nerve regeneration in mice.
The results indicate that ADIP plays an essential role in PDGF-induced cell movement by interacting with afadin and Vav2 and regulating the activation of Rac.
Title: Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein.

Submit: New GeneRIF Correction See all GeneRIFs (27)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U37017 (e-PCR)
- UniSTS:125737

AI847175 (e-PCR)
- UniSTS:164150

MTH907 (e-PCR)
- UniSTS:129339

D2Mit431.1 (e-PCR), detects polymorphism
- UniSTS:129340

D9S1337 (e-PCR)
- UniSTS:153169

Vav2 (e-PCR), detects polymorphism
- UniSTS:144744

NoName (e-PCR)
- UniSTS:234348

AW551028 (e-PCR)
- UniSTS:207304

U37017 (e-PCR)
- UniSTS:163276

AU043555 (e-PCR)
- UniSTS:158935

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell projection assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lamellipodium assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanine nucleotide exchange factor VAV2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009500.2 → NP_033526.1 guanine nucleotide exchange factor VAV2

See identical proteins and their annotated locations for NP_033526.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.

Source sequence(s)

AI847175, AL772282, BC053060, U37017

Consensus CDS

CCDS15827.1

UniProtKB/Swiss-Prot

A2AH49, Q60992

UniProtKB/TrEMBL

Q7TSI6

Related

ENSMUSP00000062782.8, ENSMUST00000056176.8

Conserved Domains (8) summary

cd10406
Location:657 → 759

SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins

cd11977
Location:809 → 866

SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein

cd11980
Location:580 → 639

SH3_VAV2_1; First Src homology 3 domain of VAV2 protein

cd00029
Location:514 → 561

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01223
Location:384 → 506

PH_Vav; Vav pleckstrin homology (PH) domain

pfam00169
Location:401 → 502

PH; PH domain

pfam00621
Location:197 → 370

RhoGEF; RhoGEF domain

pfam11971
Location:18 → 103

CAMSAP_CH; CAMSAP CH domain

RNA

NR_133905.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks a 5' exon and contains several additional exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AI847175, AL772282, BC053060

Related

ENSMUST00000185188.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

27152116..27317620 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497858.3 → XP_006497921.1 guanine nucleotide exchange factor VAV2 isoform X4

See identical proteins and their annotated locations for XP_006497921.1

UniProtKB/TrEMBL

Q7TSI6

Conserved Domains (7) summary

cd10406
Location:657 → 759

SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins

cd11977
Location:780 → 837

SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein

cd11980
Location:580 → 639

SH3_VAV2_1; First Src homology 3 domain of VAV2 protein

smart00325
Location:197 → 370

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00029
Location:514 → 561

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01223
Location:384 → 506

PH_Vav; Vav pleckstrin homology (PH) domain

pfam11971
Location:18 → 103

CAMSAP_CH; CAMSAP CH domain
XM_006497856.2 → XP_006497919.1 guanine nucleotide exchange factor VAV2 isoform X2

UniProtKB/TrEMBL

Q7TSI6

Conserved Domains (7) summary

cd10406
Location:662 → 764

SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins

cd11977
Location:814 → 871

SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein

cd11980
Location:585 → 644

SH3_VAV2_1; First Src homology 3 domain of VAV2 protein

smart00325
Location:197 → 370

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00029
Location:519 → 566

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01223
Location:384 → 511

PH_Vav; Vav pleckstrin homology (PH) domain

pfam11971
Location:18 → 103

CAMSAP_CH; CAMSAP CH domain
XM_006497854.2 → XP_006497917.1 guanine nucleotide exchange factor VAV2 isoform X1

UniProtKB/TrEMBL

Q7TSI6

Conserved Domains (7) summary

cd10406
Location:667 → 769

SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins

cd11977
Location:819 → 876

SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein

cd11980
Location:590 → 649

SH3_VAV2_1; First Src homology 3 domain of VAV2 protein

smart00325
Location:202 → 375

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00029
Location:524 → 571

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01223
Location:389 → 516

PH_Vav; Vav pleckstrin homology (PH) domain

pfam11971
Location:18 → 103

CAMSAP_CH; CAMSAP CH domain
XM_030249470.2 → XP_030105330.1 guanine nucleotide exchange factor VAV2 isoform X3

Conserved Domains (7) summary

cd10406
Location:662 → 764

SH2_Vav2; Src homology 2 (SH2) domain found in the Vav2 proteins

cd11977
Location:814 → 871

SH3_VAV2_2; C-terminal (or second) Src homology 3 domain of VAV2 protein

cd11980
Location:585 → 644

SH3_VAV2_1; First Src homology 3 domain of VAV2 protein

smart00325
Location:202 → 375

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd00029
Location:519 → 566

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd01223
Location:389 → 511

PH_Vav; Vav pleckstrin homology (PH) domain

cl00030
Location:71 → 108

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...