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Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 [ Mus musculus (house mouse) ]

Gene ID: 22163, updated on 21-Apr-2024

Summary

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Official Symbol
Tnfrsf4provided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 4provided by MGI
Primary source
MGI:MGI:104512
See related
Ensembl:ENSMUSG00000029075 AllianceGenome:MGI:104512
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L
Summary
Enables tumor necrosis factor-activated receptor activity. Involved in negative regulation of apoptotic process; positive regulation of B cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including cellular defense response; negative regulation of cytokine production; and regulation of protein kinase activity. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 16. Orthologous to human TNFRSF4 (TNF receptor superfamily member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 42.7), genital fat pad adult (RPKM 36.8) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 E2; 4 87.68 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156098049..156101070)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (156013595..156016613)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene C1q and tumor necrosis factor related 12 Neighboring gene predicted gene, 42365 Neighboring gene STARR-seq mESC enhancer starr_12278 Neighboring gene STARR-seq mESC enhancer starr_12279 Neighboring gene UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6 Neighboring gene stromal cell derived factor 4 Neighboring gene predicted gene 16008 Neighboring gene predicted gene, 25982 Neighboring gene tumor necrosis factor receptor superfamily, member 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis. Xu L, et al. Front Immunol, 2022. PMID 35720294, Free PMC Article
  2. Critical role of OX40 in drug-induced acute liver injury. Zhang C, et al. Br J Pharmacol, 2020 Jul. PMID 32133635, Free PMC Article
  3. Critical role of OX40 in the expansion and survival of CD4 T-cell-derived double-negative T cells. Sun G, et al. Cell Death Dis, 2018 May 23. PMID 29795285, Free PMC Article
  4. OX40 regulates pressure overload-induced cardiac hypertrophy and remodelling via CD4+ T-cells. Wu QQ, et al. Clin Sci (Lond), 2016 Nov 1. PMID 27580926
  5. OX40 engagement depletes intratumoral Tregs via activating FcγRs, leading to antitumor efficacy. Bulliard Y, et al. Immunol Cell Biol, 2014 Jul. PMID 24732076

See all (196) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8[+] T-cell immunity.
    Title: The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8(+) T-cell immunity.
  2. T cell specific deletion of IRF4 with Ox40-Cre impairs effector and memory T cell responses in heart transplantation.
    Title: T cell specific deletion of IRF4 with Ox40-Cre impairs effector and memory T cell responses in heart transplantation.
  3. TFAP4 promotes the progression of liver fibrosis through regulating double-negative T cell differentiation via OX40.
    Title: TFAP4 promotes the progression of liver fibrosis through regulating double-negative T cell differentiation via OX40.
  4. OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum.
    Title: OX40 agonism enhances PD-L1 checkpoint blockade by shifting the cytotoxic T cell differentiation spectrum.
  5. OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis.
    Title: OX40 Expression in Eosinophils Aggravates OVA-Induced Eosinophilic Gastroenteritis.
  6. Prolongation of allograft survival by artemisinin treatment is associated with blockade of OX40-OX40L.
    Title: Prolongation of allograft survival by artemisinin treatment is associated with blockade of OX40-OX40L.
  7. Critical role of OX40 in drug-induced acute liver injury.
    Title: Critical role of OX40 in drug-induced acute liver injury.
  8. Blockade of tumor necrosis factor superfamily members CD30 and OX40 abrogates disease activity in murine immune-mediated glomerulonephritis.
    Title: Blockade of tumor necrosis factor superfamily members CD30 and OX40 abrogates disease activity in murine immune-mediated glomerulonephritis.
  9. OX40 expression in neutrophils promotes hepatic ischemia/reperfusion injury.
    Title: OX40 expression in neutrophils promotes hepatic ischemia/reperfusion injury.
  10. Pulmonary group 2 innate lymphoid cells may regulate RSV-induced CD4+T cell expansion and activation via OX40/OX40L interaction. Our results might provide a novel understanding of the underlying mechanisms of respiratory tract diseases mediated by type 2 immunity and be useful to improve the insights and therapies for RSV-induced or RSV-aggravated asthma.
    Title: Critical role of OX40/OX40L in ILC2-mediated activation of CD4(+)T cells during respiratory syncytial virus infection in mice.
Submit: New GeneRIF Correction See all GeneRIFs (110)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (10) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables tumor necrosis factor receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tumor necrosis factor receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular defense response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inflammatory response IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of activation-induced cell death of T cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cytokine production IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of immunoglobulin production IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within programmed cell death IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tumor necrosis factor-mediated signaling pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 4
Names
OX40 antigen
OX40L receptor
tax-transcriptionally activated glycoprotein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011659.2 → NP_035789.1  tumor necrosis factor receptor superfamily member 4 precursor

    See identical proteins and their annotated locations for NP_035789.1

    Status: PROVISIONAL

    Source sequence(s)
    AL627204
    Consensus CDS
    CCDS19055.1
    UniProtKB/Swiss-Prot
    P47741
    UniProtKB/TrEMBL
    B1ASL3
    Related
    ENSMUSP00000030952.6, ENSMUST00000030952.6
    Conserved Domains (1) summary
    cd13406
    Location:25 → 168
    TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    156098049..156101070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538724.4 → XP_006538787.3  tumor necrosis factor receptor superfamily member 4 isoform X1

    Conserved Domains (1) summary
    cd13406
    Location:113 → 256
    TNFRSF4; Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), also known as CD134 or OXO40
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47741.1 GenPept UniProtKB/Swiss-Prot:P47741

Gene LinkOut

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