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Tsks testis-specific serine kinase substrate [ Mus musculus (house mouse) ]

Gene ID: 22116, updated on 5-Mar-2024

Summary

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Official Symbol
Tsksprovided by MGI
Official Full Name
testis-specific serine kinase substrateprovided by MGI
Primary source
MGI:MGI:1347560
See related
Ensembl:ENSMUSG00000059891 AllianceGenome:MGI:1347560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tssks1; Stk22s1
Summary
This gene is a member of a small family of testis-specific serine/threonine kinases. This gene may play a role in testicular physiology or spermiogenesis. Its expression is restricted to the testis during the last stages of spermatid maturation. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis adult (RPKM 199.6) See more
Orthologs
human all
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Genomic context

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See Tsks in Genome Data Viewer
Location:
7 B3; 7 29.07 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44579044..44607465)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (44929472..44958041)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 25 Neighboring gene STARR-positive B cell enhancer ABC_E8171 Neighboring gene STARR-positive B cell enhancer ABC_E547 Neighboring gene fuzzy planar cell polarity protein Neighboring gene adaptor-related protein complex 2, alpha 1 subunit Neighboring gene STARR-positive B cell enhancer ABC_E88 Neighboring gene carnitine palmitoyltransferase 1c Neighboring gene STARR-seq mESC enhancer starr_18822 Neighboring gene protein arginine N-methyltransferase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation. Shimada K, et al. Proc Natl Acad Sci U S A, 2023 Mar 14. PMID 36881620, Free PMC Article
  2. PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis. MacLeod G, et al. Reproduction, 2014 Jan. PMID 24088291
  3. Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases. Shang P, et al. J Cell Sci, 2010 Feb 1. PMID 20053632
  4. A novel family of serine/threonine kinases participating in spermiogenesis. Kueng P, et al. J Cell Biol, 1997 Dec 29. PMID 9412477, Free PMC Article
  5. TSKS concentrates in spermatid centrioles during flagellogenesis. Xu B, et al. Dev Biol, 2008 Jul 15. PMID 18495105, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation.
    Title: TSKS localizes to nuage in spermatids and regulates cytoplasmic elimination during spermiation.
  2. In mouse testis, PPP1CC2 can form a complex with TSSK1 mediated by the direct interaction of each with the kinase substrate protein TSKS. Interaction between PPP1CC2 and TSKS is mediated through an RVxF docking motif on the TSKS surface.
    Title: PPP1CC2 can form a kinase/phosphatase complex with the testis-specific proteins TSSK1 and TSKS in the mouse testis.
  3. In elongating spermatids, data detected accumulation of the testis-specific TSSK1 and TSSK2, and the substrate TSKS, in a ring-shaped structure around the base of the flagellum and in a cytoplasmic satellite.
    Title: Functional transformation of the chromatoid body in mouse spermatids requires testis-specific serine/threonine kinases.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC148222

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle TAS
Traceable Author Statement
more info
 PubMed 
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
testis-specific serine kinase substrate
Names
STK22 substrate 1
clone 4
serine/threonine kinase 22 substrate 1
testis-specific kinase substrate
testis-specific serine/threonine kinase substrate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077591.1 → NP_001071059.1  testis-specific serine kinase substrate isoform 2

    See identical proteins and their annotated locations for NP_001071059.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple in-frame differences in the coding region, compared to variant 1, which results in a shorter protein (isoform 2).
    Source sequence(s)
    BC121827, BX630702, CJ047818
    Consensus CDS
    CCDS39946.1
    UniProtKB/TrEMBL
    Q147V4
    Related
    ENSMUSP00000079122.7, ENSMUST00000080233.9
    Conserved Domains (1) summary
    pfam15358
    Location:26 → 525
    TSKS; Testis-specific serine kinase substrate

  2. NM_001417444.1 → NP_001404373.1  testis-specific serine kinase substrate isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC155806

  3. NM_001417445.1 → NP_001404374.1  testis-specific serine kinase substrate isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC155806, AC158231

  4. NM_001417446.1 → NP_001404375.1  testis-specific serine kinase substrate isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC155806, AC158231

  5. NM_011651.2 → NP_035781.2  testis-specific serine kinase substrate isoform 1

    See identical proteins and their annotated locations for NP_035781.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer protein (isoform 1).
    Source sequence(s)
    BC121827, BX630702, CJ047818, CN831975
    Consensus CDS
    CCDS52240.1
    UniProtKB/Swiss-Prot
    E9QJS9, O54887
    Related
    ENSMUSP00000112673.2, ENSMUST00000120929.9
    Conserved Domains (1) summary
    pfam15358
    Location:26 → 585
    TSKS; Testis-specific serine kinase substrate

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44579044..44607465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540793.5 → XP_006540856.1  testis-specific serine kinase substrate isoform X3

    Conserved Domains (1) summary
    pfam15358
    Location:15 → 580
    TSKS; Testis-specific serine kinase substrate

  2. XM_006540791.3 → XP_006540854.1  testis-specific serine kinase substrate isoform X1

    Conserved Domains (1) summary
    pfam15358
    Location:26 → 610
    TSKS; Testis-specific serine kinase substrate

  3. XM_006540792.3 → XP_006540855.1  testis-specific serine kinase substrate isoform X2

    Conserved Domains (1) summary
    pfam15358
    Location:26 → 601
    TSKS; Testis-specific serine kinase substrate

  4. XM_006540796.3 → XP_006540859.1  testis-specific serine kinase substrate isoform X6

    Conserved Domains (1) summary
    pfam15358
    Location:26 → 573
    TSKS; Testis-specific serine kinase substrate

  5. XM_006540794.3 → XP_006540857.1  testis-specific serine kinase substrate isoform X4

    Conserved Domains (1) summary
    pfam15358
    Location:26 → 576
    TSKS; Testis-specific serine kinase substrate

  6. XM_006540795.4 → XP_006540858.1  testis-specific serine kinase substrate isoform X5

    Conserved Domains (1) summary
    pfam15358
    Location:26 → 492
    TSKS; Testis-specific serine kinase substrate
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54887.4 GenPept UniProtKB/Swiss-Prot:O54887

Gene LinkOut

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