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Trpc4 transient receptor potential cation channel, subfamily C, member 4 [ Mus musculus (house mouse) ]

Gene ID: 22066, updated on 11-Apr-2024

Summary

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Official Symbol
Trpc4provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily C, member 4provided by MGI
Primary source
MGI:MGI:109525
See related
Ensembl:ENSMUSG00000027748 AllianceGenome:MGI:109525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCE1; Trp4; Trrp4; STRPC4
Summary
Enables inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Acts upstream of or within gamma-aminobutyric acid secretion and oligodendrocyte differentiation. Located in caveola. Part of protein-containing complex. Is expressed in several structures, including brain; cochlea; ganglia; genitourinary system; and liver. Orthologous to human TRPC4 (transient receptor potential cation channel subfamily C member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 2.6), CNS E18 (RPKM 2.6) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Trpc4 in Genome Data Viewer
Location:
3 C; 3 25.43 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (54063441..54225892)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (54155584..54318471)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A pseudogene Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07672 Neighboring gene STARR-seq mESC enhancer starr_07673 Neighboring gene STARR-seq mESC enhancer starr_07674 Neighboring gene predicted gene, 54174 Neighboring gene predicted gene, 31095 Neighboring gene periostin, osteoblast specific factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice. Zhou Q, et al. Neuron, 2023 Feb 1. PMID 36476978
  2. TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect G(q/11)-G(i/o) coincidence signals of variable strengths. Tian JB, et al. Proc Natl Acad Sci U S A, 2022 May 17. PMID 35544691, Free PMC Article
  3. Sensory Neuron-Expressed TRPC4 Is a Target for the Relief of Psoriasiform Itch and Skin Inflammation in Mice. Lee SH, et al. J Invest Dermatol, 2020 Nov. PMID 32289348
  4. Structure of the mouse TRPC4 ion channel. Duan J, et al. Nat Commun, 2018 Aug 6. PMID 30082700, Free PMC Article
  5. Suppression of transient receptor potential canonical channel 4 inhibits vascular endothelial growth factor-induced retinal neovascularization. Song HB, et al. Cell Calcium, 2015 Feb. PMID 25605522

See all (104) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice.
    Title: Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice.
  2. TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect Gq/11-Gi/o coincidence signals of variable strengths.
    Title: TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect G(q/11)-G(i/o) coincidence signals of variable strengths.
  3. Sensory Neuron-Expressed TRPC4 Is a Target for the Relief of Psoriasiform Itch and Skin Inflammation in Mice.
    Title: Sensory Neuron-Expressed TRPC4 Is a Target for the Relief of Psoriasiform Itch and Skin Inflammation in Mice.
  4. Intracellular acidification facilitates receptor-operated TRPC4 activation through PLCdelta1 in a Ca(2+) -dependent manner.
    Title: Intracellular acidification facilitates receptor-operated TRPC4 activation through PLCδ1 in a Ca(2+) -dependent manner.
  5. Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells.
    Title: Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells.
  6. This study demonstrates that TRPC4 channels are involved in spontaneous and cholinergic-mediated contractions of the murine detrusor.
    Title: Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice.
  7. TRPC4 mediates itch and scratching behavior evoked by serotonergic antidepressants
    Title: Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice.
  8. analysis of mouse TRPC4 ion channel by cryoelectron microscopy reveals how its cytosolic N-terminal domain forms extensive aromatic contacts with the TRP and the C-terminal domains
    Title: Structure of the mouse TRPC4 ion channel.
  9. These results indicate the contribution of heteromultimeric channels from TRPC1, TRPC4, and TRPC5 subunits to the regulation of mechanisms underlying spatial working memory and flexible relearning by facilitating proper synaptic transmission in hippocampal neurons.
    Title: Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory.
  10. the antidepressant and anxiolytic-like effects of a newly identified TRPC4/C5 inhibitor, M084.
    Title: Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol 1,4,5 trisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables store-operated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in calcium ion import ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gamma-aminobutyric acid secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of store-operated calcium entry ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of action potential firing rate ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of calcium channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in caveola IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cortical cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
short transient receptor potential channel 4
Names
capacitative calcium entry channel Trp4
putative capacitative calcium entry channel
receptor-activated cation channel TRP4
transient receptor protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253682.2 → NP_001240611.1  short transient receptor potential channel 4 isoform 2

    See identical proteins and their annotated locations for NP_001240611.1

    Status: VALIDATED

    Source sequence(s)
    AC117594, AC132438
    Consensus CDS
    CCDS79904.1
    UniProtKB/TrEMBL
    Q8BNT2
    Related
    ENSMUSP00000143593.2, ENSMUST00000200048.5
    Conserved Domains (2) summary
    TIGR00870
    Location:17 → 749
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:122 → 167
    ANK; ANK repeat [structural motif]

  2. NM_001253683.2 → NP_001240612.1  short transient receptor potential channel 4 isoform 3

    See identical proteins and their annotated locations for NP_001240612.1

    Status: VALIDATED

    Source sequence(s)
    AC117594, AC132438
    UniProtKB/TrEMBL
    A0A0G2JEV6, Q8BNB6
    Related
    ENSMUST00000199399.5
    Conserved Domains (4) summary
    cd00204
    Location:64 → 168
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08344
    Location:176 → 235
    TRP_2; Transient receptor ion channel II
    pfam12796
    Location:39 → 168
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:122 → 167
    ANK; ANK repeat [structural motif]

  3. NM_001428708.1 → NP_001415637.1  short transient receptor potential channel 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117594, AC132438
    UniProtKB/Swiss-Prot
    Q62350, Q9QUQ5, Q9QUQ9, Q9QZC0
    UniProtKB/TrEMBL
    Q0VB97

  4. NM_016984.4 → NP_058680.1  short transient receptor potential channel 4 isoform 1

    See identical proteins and their annotated locations for NP_058680.1

    Status: VALIDATED

    Source sequence(s)
    AC117594, AC132438
    Consensus CDS
    CCDS17350.1
    UniProtKB/Swiss-Prot
    Q62350, Q9QUQ5, Q9QUQ9, Q9QZC0
    UniProtKB/TrEMBL
    Q0VB97, Q8BNT2
    Related
    ENSMUSP00000029311.7, ENSMUST00000029311.11
    Conserved Domains (2) summary
    TIGR00870
    Location:17 → 749
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:122 → 167
    ANK; ANK repeat [structural motif]

RNA

  1. NR_046161.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117594, AC132438

  2. NR_190476.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117594, AC132438

  3. NR_190477.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117594, AC132438

  4. NR_190478.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117594, AC132438

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    54063441..54225892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319534.3 → XP_017175023.1  short transient receptor potential channel 4 isoform X2

    UniProtKB/TrEMBL
    Q8BNT2
    Conserved Domains (2) summary
    TIGR00870
    Location:17 → 749
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:122 → 167
    ANK; ANK repeat [structural motif]

  2. XM_006501298.3 → XP_006501361.1  short transient receptor potential channel 4 isoform X4

    See identical proteins and their annotated locations for XP_006501361.1

    Conserved Domains (1) summary
    TIGR00870
    Location:1 → 329
    trp; transient-receptor-potential calcium channel protein

  3. XM_036163020.1 → XP_036018913.1  short transient receptor potential channel 4 isoform X4

    Conserved Domains (1) summary
    TIGR00870
    Location:1 → 329
    trp; transient-receptor-potential calcium channel protein

  4. XM_006501296.4 → XP_006501359.1  short transient receptor potential channel 4 isoform X1

    Conserved Domains (2) summary
    TIGR00870
    Location:17 → 749
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:122 → 167
    ANK; ANK repeat [structural motif]

  5. XM_006501297.5 → XP_006501360.1  short transient receptor potential channel 4 isoform X4

    Conserved Domains (1) summary
    TIGR00870
    Location:1 → 329
    trp; transient-receptor-potential calcium channel protein

  6. XM_036163021.1 → XP_036018914.1  short transient receptor potential channel 4 isoform X4

    Conserved Domains (1) summary
    TIGR00870
    Location:1 → 329
    trp; transient-receptor-potential calcium channel protein

  7. XM_036163019.1 → XP_036018912.1  short transient receptor potential channel 4 isoform X3

    Conserved Domains (1) summary
    TIGR00870
    Location:1 → 420
    trp; transient-receptor-potential calcium channel protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QUQ5.1 GenPept UniProtKB/Swiss-Prot:Q9QUQ5

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