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Trpc1 transient receptor potential cation channel, subfamily C, member 1 [ Mus musculus (house mouse) ]

Gene ID: 22063, updated on 21-Apr-2024

Summary

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Official Symbol
Trpc1provided by MGI
Official Full Name
transient receptor potential cation channel, subfamily C, member 1provided by MGI
Primary source
MGI:MGI:109528
See related
Ensembl:ENSMUSG00000032839 AllianceGenome:MGI:109528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Trp1; Mtrp1; Trrp1
Summary
Enables store-operated calcium channel activity. Acts upstream of or within saliva secretion. Located in basolateral plasma membrane; membrane raft; and myofibril. Part of protein-containing complex. Is expressed in cochlea; dorsal root ganglion; spinal cord; and vagus ganglion. Orthologous to human TRPC1 (transient receptor potential cation channel subfamily C member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 5.3), frontal lobe adult (RPKM 4.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 E3.3; 9 50.2 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (95587125..95632438, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (95705072..95750386, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16126 Neighboring gene predicted gene, 25582 Neighboring gene procollagen C-endopeptidase enhancer 2 Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase) pseudogene 2 Neighboring gene predicted gene, 39407 Neighboring gene plastin 1 (I-isoform) Neighboring gene VISTA enhancer mm1367 Neighboring gene RIKEN cDNA 1700065D16 gene Neighboring gene STARR-positive B cell enhancer ABC_E5095 Neighboring gene STARR-positive B cell enhancer ABC_E894 Neighboring gene ataxia telangiectasia and Rad3 related

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effects of maternal HF diet and absence of TRPC1 gene on mouse placental growth and fetal intrauterine growth retardation (IUGR). Claycombe-Larson K, et al. J Nutr Biochem, 2023 Apr. PMID 36243380
  2. Lipidomic Analysis of TRPC1 Ca(2+)-Permeable Channel-Knock Out Mouse Demonstrates a Vital Role in Placental Tissue Sphingolipid and Triacylglycerol Homeostasis Under Maternal High-Fat Diet. Bukowski MR, et al. Front Endocrinol (Lausanne), 2022. PMID 35360063, Free PMC Article
  3. Cell-Derived Vesicles as TRPC1 Channel Delivery Systems for the Recovery of Cellular Respiratory and Proliferative Capacities. Kurth F, et al. Adv Biosyst, 2020 Nov. PMID 32875708
  4. TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons. Kepura F, et al. Cells, 2020 Feb 18. PMID 32085504, Free PMC Article
  5. Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism. Yap JLY, et al. FASEB J, 2019 Nov. PMID 31518158, Free PMC Article

See all (153) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of TRPC1 in microglia promotes neutrophil infiltration after ischemic stroke.
    Title: Upregulation of TRPC1 in microglia promotes neutrophil infiltration after ischemic stroke.
  2. Effects of maternal HF diet and absence of TRPC1 gene on mouse placental growth and fetal intrauterine growth retardation (IUGR).
    Title: Effects of maternal HF diet and absence of TRPC1 gene on mouse placental growth and fetal intrauterine growth retardation (IUGR).
  3. TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Muller cells.
    Title: TRPV4 and TRPC1 channels mediate the response to tensile strain in mouse Müller cells.
  4. Cell-Derived Vesicles as TRPC1 Channel Delivery Systems for the Recovery of Cellular Respiratory and Proliferative Capacities.
    Title: Cell-Derived Vesicles as TRPC1 Channel Delivery Systems for the Recovery of Cellular Respiratory and Proliferative Capacities.
  5. TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons.
    Title: TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons.
  6. Store-operated Ca(2+) entry in primary murine lung fibroblasts is independent of classical transient receptor potential (TRPC) channels and contributes to cell migration.
    Title: Store-operated Ca(2+) entry in primary murine lung fibroblasts is independent of classical transient receptor potential (TRPC) channels and contributes to cell migration.
  7. Loss of Ca(2+) entry via Orai-TRPC1 induces ER stress, initiating immune activation in macrophages.
    Title: Loss of Ca(2+) entry via Orai-TRPC1 induces ER stress, initiating immune activation in macrophages.
  8. These results suggest an unequivocal role of TRPC1 in adipocyte differentiation and adiponectin secretion, and that loss of TRPC1 disturbs metabolic homeostasis.
    Title: Ca(2+) entry via TRPC1 is essential for cellular differentiation and modulates secretion via the SNARE complex.
  9. Stimulation of calcium-sensing receptors activates heteromeric TRPV4/TRPC1 channels and NO production in endothelial cells, which are responsible for endothelium-dependent vasorelaxations.
    Title: Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1(-/-) mice.
  10. Magnetism thus deploys an authentic myogenic directive that relies on an interplay between mitochondria and TRPC1 to reach fruition.
    Title: Ambient and supplemental magnetic fields promote myogenesis via a TRPC1-mitochondrial axis: evidence of a magnetic mitohormetic mechanism.
Submit: New GeneRIF Correction See all GeneRIFs (89)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Chemically induced (ENU) (3) 
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol 1,4,5 trisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol 1,4,5 trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic cation channel activity ISO
Inferred from Sequence Orthology
more info
  
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables store-operated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables store-operated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ion channel modulating, G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in ligand-gated ion channel signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in melanin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within saliva secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in costamere IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in sarcomere IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
short transient receptor potential channel 1
Names
transient receptor protein 1
trp-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311123.2 → NP_001298052.2  short transient receptor potential channel 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC091531, AC157947
    Consensus CDS
    CCDS81052.1
    Related
    ENSMUSP00000057640.5, ENSMUST00000053785.10
    Conserved Domains (2) summary
    TIGR00870
    Location:48 → 740
    trp; transient-receptor-potential calcium channel protein
    sd00045
    Location:83 → 117
    ANK; ANK repeat [structural motif]

  2. NM_001413351.1 → NP_001400280.1  short transient receptor potential channel 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091531, AC157947

  3. NM_001413352.1 → NP_001400281.1  short transient receptor potential channel 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC091531, AC157947

  4. NM_001413353.1 → NP_001400282.1  short transient receptor potential channel 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC091531, AC157947

  5. NM_001413354.1 → NP_001400283.1  short transient receptor potential channel 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC091531, AC157947

  6. NM_011643.4 → NP_035773.2  short transient receptor potential channel 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC091531, AC157947
    Consensus CDS
    CCDS23411.1
    UniProtKB/Swiss-Prot
    O35722, Q61056
    Related
    ENSMUSP00000139672.2, ENSMUST00000189137.7
    Conserved Domains (1) summary
    TIGR00870
    Location:48 → 774
    trp; transient-receptor-potential calcium channel protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    95587125..95632438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244242.2 → XP_030100102.1  short transient receptor potential channel 1 isoform X4

    Conserved Domains (1) summary
    TIGR00870
    Location:12 → 622
    trp; transient-receptor-potential calcium channel protein

  2. XM_006511057.3 → XP_006511120.1  short transient receptor potential channel 1 isoform X5

    Conserved Domains (1) summary
    TIGR00870
    Location:12 → 629
    trp; transient-receptor-potential calcium channel protein

  3. XM_030244244.2 → XP_030100104.1  short transient receptor potential channel 1 isoform X8

    Conserved Domains (1) summary
    TIGR00870
    Location:36 → 377
    trp; transient-receptor-potential calcium channel protein

  4. XM_030244243.1 → XP_030100103.1  short transient receptor potential channel 1 isoform X6

    Conserved Domains (1) summary
    TIGR00870
    Location:64 → 598
    trp; transient-receptor-potential calcium channel protein

  5. XM_011242717.4 → XP_011241019.1  short transient receptor potential channel 1 isoform X7

    Conserved Domains (1) summary
    TIGR00870
    Location:64 → 413
    trp; transient-receptor-potential calcium channel protein

RNA

  1. XR_003947858.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61056.5 GenPept UniProtKB/Swiss-Prot:Q61056

Gene LinkOut

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