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Crisp2 cysteine-rich secretory protein 2 [ Mus musculus (house mouse) ]

Gene ID: 22024, updated on 21-Apr-2024

Summary

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Official Symbol
Crisp2provided by MGI
Official Full Name
cysteine-rich secretory protein 2provided by MGI
Primary source
MGI:MGI:98815
See related
Ensembl:ENSMUSG00000023930 AllianceGenome:MGI:98815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tpx1; Tpx-1; GAPDL5; CRISP-2
Summary
Predicted to be involved in cell-cell adhesion. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CRISP2 (cysteine rich secretory protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 326.9) See more
Orthologs
human all
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Genomic context

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Location:
17 B2; 17 19.54 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (41075625..41105037, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (40764734..40794146, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene exocrine gland secreted peptide 3 Neighboring gene STARR-seq mESC enhancer starr_42547 Neighboring gene exocrine gland secreted peptide 1 Neighboring gene Rhesus blood group-associated A glycoprotein Neighboring gene STARR-seq mESC enhancer starr_42548 Neighboring gene STARR-seq mESC enhancer starr_42549 Neighboring gene cytochrome P450, family 2, subfamily ac, polypeptide 1, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRISP2 Is a Regulator of Multiple Aspects of Sperm Function and Male Fertility. Lim S, et al. Endocrinology, 2019 Apr 1. PMID 30759213
  2. Evidence for the involvement of testicular protein CRISP2 in mouse sperm-egg fusion. Busso D, et al. Biol Reprod, 2007 Apr. PMID 17202389
  3. The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling. Gibbs GM, et al. J Biol Chem, 2006 Feb 17. PMID 16339766
  4. Random cloning of genes from mouse chromosome 17. Kasahara M, et al. Proc Natl Acad Sci U S A, 1987 May. PMID 3472212, Free PMC Article
  5. Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: implications for fertility disorders. Brukman NG, et al. Mol Hum Reprod, 2016 Apr. PMID 26786179

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we revealed a role for CRISP2 in establishing the ability of sperm to undergo the acrosome reaction and in establishing a normal flagellum waveform. Crisp2-deficient sperm possess a stiff midpiece and are thus unable to manifest the rapid form of progressive motility seen in wild type sperm. As a consequence, Crisp2-deficient males are subfertile.
    Title: CRISP2 Is a Regulator of Multiple Aspects of Sperm Function and Male Fertility.
  2. Crisp2 genetic defects in sperm from humans and mice result in male infertility.
    Title: Fertilization defects in sperm from Cysteine-rich secretory protein 2 (Crisp2) knockout mice: implications for fertility disorders.
  3. expression and localization of SHTAP in testis and sperm raise the possibility that the SHTAP-CRISP2 complex has a potential role in sperm formation and/or function.
    Title: A novel protein, sperm head and tail associated protein (SHTAP), interacts with cysteine-rich secretory protein 2 (CRISP2) during spermatogenesis in the mouse.
  4. These data raise the possibility that CRISP2 is a MAP3K11-modifying protein or, alternatively, that MAP3K11 acts to phosphorylate CRISP2 during acrosome development.
    Title: Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm.
  5. Evidence for a functional role of CRISP2 in fertilization.
    Title: Evidence for the involvement of testicular protein CRISP2 in mouse sperm-egg fusion.
  6. Tpx-1 Crisp domain on its own can regulate ion channel activity and provide compelling evidence for a role for Tpx-1 in the regulation of Ca(2+) fluxes observed during sperm capacitation.
    Title: The cysteine-rich secretory protein domain of Tpx-1 is related to ion channel toxins and regulates ryanodine receptor Ca2+ signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cysteine-rich secretory protein 2
Names
testis specific gene 1
testis-specific protein TPX-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204071.1 → NP_001191000.1  cysteine-rich secretory protein 2 precursor

    See identical proteins and their annotated locations for NP_001191000.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC135084, BC049615, CJ046590
    Consensus CDS
    CCDS28786.1
    UniProtKB/Swiss-Prot
    P16563
    Conserved Domains (2) summary
    cd05383
    Location:36 → 171
    SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
    pfam08562
    Location:189 → 243
    Crisp; Crisp

  2. NM_009420.2 → NP_033446.1  cysteine-rich secretory protein 2 precursor

    See identical proteins and their annotated locations for NP_033446.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC135084, BC049615
    Consensus CDS
    CCDS28786.1
    UniProtKB/Swiss-Prot
    P16563
    Related
    ENSMUSP00000024724.8, ENSMUST00000024724.14
    Conserved Domains (2) summary
    cd05383
    Location:36 → 171
    SCP_CRISP; SCP_CRISP: SCP-like extracellular protein domain, CRISP-like sub-family. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, which combine SCP with a ...
    pfam08562
    Location:189 → 243
    Crisp; Crisp

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    41075625..41105037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524036.3 → XP_006524099.1  cysteine-rich secretory protein 2 isoform X1

    Conserved Domains (2) summary
    pfam08562
    Location:128 → 182
    Crisp
    cl00133
    Location:1 → 111
    CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family

  2. XM_030249644.1 → XP_030105504.1  cysteine-rich secretory protein 2 isoform X1

    Conserved Domains (2) summary
    pfam08562
    Location:128 → 182
    Crisp
    cl00133
    Location:1 → 111
    CAP; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16563.1 GenPept UniProtKB/Swiss-Prot:P16563

Gene LinkOut

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