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Tpo thyroid peroxidase [ Mus musculus (house mouse) ]

Gene ID: 22018, updated on 11-Apr-2024

Summary

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Official Symbol
Tpoprovided by MGI
Official Full Name
thyroid peroxidaseprovided by MGI
Primary source
MGI:MGI:98813
See related
Ensembl:ENSMUSG00000020673 AllianceGenome:MGI:98813
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes a membrane-bound glycoprotein. The encoded enzyme plays a central role in thyroid gland function. The enzyme functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mice with homozygous missense mutations in this gene exhibit hypothyroid dwarfism and hearing impairment. [provided by RefSeq, Sep 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
12 A2; 12 13.0 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (30104658..30182983, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (30054659..30132984, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene myelin transcription factor 1-like Neighboring gene predicted gene, 46346 Neighboring gene predicted gene, 31939 Neighboring gene STARR-seq mESC enhancer starr_31838 Neighboring gene peroxidasin Neighboring gene STARR-seq mESC enhancer starr_31839 Neighboring gene STARR-seq mESC enhancer starr_31840 Neighboring gene STARR-seq mESC enhancer starr_31841 Neighboring gene predicted gene 15691 Neighboring gene predicted gene, 40873 Neighboring gene predicted gene, 32084

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene. Johnson KR, et al. J Assoc Res Otolaryngol, 2014 Feb. PMID 24297261, Free PMC Article
  2. A novel hypothyroid dwarfism due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse. Takabayashi S, et al. Mol Endocrinol, 2006 Oct. PMID 16762971
  3. Ascidian homologs of mammalian thyroid peroxidase genes are expressed in the thyroid-equivalent region of the endostyle. Ogasawara M, et al. J Exp Zool, 1999 Aug 15. PMID 10440727
  4. Nucleotide sequence of the cDNA encoding mouse thyroid peroxidase. Kotani T, et al. Gene, 1993 Jan 30. PMID 7916704
  5. Normal peroxidase activity in Pendred's syndrome. Burrow GN, et al. J Clin Endocrinol Metab, 1973 Mar. PMID 4346605

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype
    Title: Lnk Deficiency Leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype.
  2. Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene.
    Title: Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene.
  3. Findings demonstrate a novel aspect of murine and human thyroid autoimmunity, namely breaking B cell self-tolerance occurs first for Tg and subsequently for TPO.
    Title: Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies.
  4. A novel hypothyroid dwarfism is due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse.
    Title: A novel hypothyroid dwarfism due to the missense mutation Arg479Cys of the thyroid peroxidase gene in the mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iodide peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in embryonic hemopoiesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hydrogen peroxide catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in thyroid hormone generation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
thyroid peroxidase
NP_033443.1
XP_011242158.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009417.3 → NP_033443.1  thyroid peroxidase precursor

    See identical proteins and their annotated locations for NP_033443.1

    Status: REVIEWED

    Source sequence(s)
    AC157276, X60703
    Consensus CDS
    CCDS25857.1
    UniProtKB/Swiss-Prot
    P35419, Q8C8B1
    Related
    ENSMUSP00000021005.9, ENSMUST00000021005.15
    Conserved Domains (4) summary
    cd00033
    Location:730 → 783
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:161 → 722
    thyroid_peroxidase; Thyroid peroxidase (TPO)
    pfam03098
    Location:145 → 687
    An_peroxidase; Animal haem peroxidase
    pfam07645
    Location:784 → 826
    EGF_CA; Calcium-binding EGF domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    30104658..30182983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243856.3 → XP_011242158.1  thyroid peroxidase isoform X1

    Conserved Domains (3) summary
    cd00033
    Location:730 → 783
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd09825
    Location:161 → 722
    thyroid_peroxidase; Thyroid peroxidase (TPO)
    pfam07645
    Location:784 → 826
    EGF_CA; Calcium-binding EGF domain

RNA

  1. XR_003950045.1 RNA Sequence

  2. XR_872405.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35419.1 GenPept UniProtKB/Swiss-Prot:P35419

Gene LinkOut

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