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Tnc tenascin C [ Mus musculus (house mouse) ]

Gene ID: 21923, updated on 21-Apr-2024

Summary

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Official Symbol
Tncprovided by MGI
Official Full Name
tenascin Cprovided by MGI
Primary source
MGI:MGI:101922
See related
Ensembl:ENSMUSG00000028364 AllianceGenome:MGI:101922
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TN; Hxb; Ten; TN-C; cytotactin; tenascin-C; C130033P17Rik
Summary
Predicted to enable fibronectin binding activity and syndecan binding activity. Acts upstream of or within several processes, including neuromuscular junction development; peripheral nervous system axon regeneration; and prostate gland development. Located in collagen-containing extracellular matrix and extracellular region. Is expressed in several structures, including alimentary system; brain; immune system; ovary; and skeletal system. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; autosomal dominant nonsyndromic deafness 56; and pulmonary hypertension. Orthologous to human TNC (tenascin C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 49.7), bladder adult (RPKM 28.6) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 C1; 4 34.06 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63878022..63965554, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63959785..64047015, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10447 Neighboring gene tumor necrosis factor (ligand) superfamily, member 8 Neighboring gene ribosomal protein L17, pseudogene 4 Neighboring gene RIKEN cDNA 8030451A03 gene Neighboring gene STARR-seq mESC enhancer starr_10448 Neighboring gene STARR-seq mESC enhancer starr_10449 Neighboring gene predicted gene, 31115 Neighboring gene STARR-seq mESC enhancer starr_10450 Neighboring gene STARR-seq mESC enhancer starr_10451 Neighboring gene predicted gene 11217 Neighboring gene STARR-seq mESC enhancer starr_10452 Neighboring gene STARR-seq mESC enhancer starr_10453 Neighboring gene STARR-seq mESC enhancer starr_10454 Neighboring gene predicted gene, 23950

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Matrix protein Tenascin-C promotes kidney fibrosis via STAT3 activation in response to tubular injury. Xie Q, et al. Cell Death Dis, 2022 Dec 15. PMID 36522320, Free PMC Article
  2. Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs. Hongu T, et al. Nat Cancer, 2022 Apr. PMID 35469015, Free PMC Article
  3. The extracellular matrix molecule tenascin-C modulates cell cycle progression and motility of adult neural stem/progenitor cells from the subependymal zone. Schaberg E, et al. Cell Mol Life Sci, 2022 Apr 16. PMID 35430697, Free PMC Article
  4. Tenascin-C restricts reactive astrogliosis in the ischemic brain. Dzyubenko E, et al. Matrix Biol, 2022 Jun. PMID 35430380
  5. The expression and role of tenascin C in abdominal aortic aneurysm formation and progression. Nagel F, et al. Interact Cardiovasc Thorac Surg, 2022 May 2. PMID 35137102, Free PMC Article

See all (430) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tenascin-C promotes endochondral ossification and fracture healing through Hedgehog and Hippo signaling.
    Title: Tenascin-C promotes endochondral ossification and fracture healing through Hedgehog and Hippo signaling.
  2. Role of tenascin C in lesion formation in early peritoneal endometriosis.
    Title: Role of tenascin C in lesion formation in early peritoneal endometriosis.
  3. Characteristics of n6-methyladenosine (m6A) regulators and role of FTO/TNC in scleroderma.
    Title: Characteristics of n6-methyladenosine (m6A) regulators and role of FTO/TNC in scleroderma.
  4. Investigating Chemokine-Matrix Networks in Breast Cancer: Tenascin-C Sets the Tone for CCL2.
    Title: Investigating Chemokine-Matrix Networks in Breast Cancer: Tenascin-C Sets the Tone for CCL2.
  5. TNC Accelerates Hypoxia-Induced Cardiac Injury in a METTL3-Dependent Manner.
    Title: TNC Accelerates Hypoxia-Induced Cardiac Injury in a METTL3-Dependent Manner.
  6. Matrix protein Tenascin-C promotes kidney fibrosis via STAT3 activation in response to tubular injury.
    Title: Matrix protein Tenascin-C promotes kidney fibrosis via STAT3 activation in response to tubular injury.
  7. The Prostaglandin E2 Receptor EP4 Promotes Vascular Neointimal Hyperplasia through Translational Control of Tenascin C via the cAPM/PKA/mTORC1/rpS6 Pathway.
    Title: The Prostaglandin E2 Receptor EP4 Promotes Vascular Neointimal Hyperplasia through Translational Control of Tenascin C via the cAPM/PKA/mTORC1/rpS6 Pathway.
  8. Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.
    Title: Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.
  9. The Extracellular Matrix Proteins Tenascin-C and Tenascin-R Retard Oligodendrocyte Precursor Maturation and Myelin Regeneration in a Cuprizone-Induced Long-Term Demyelination Animal Model.
    Title: The Extracellular Matrix Proteins Tenascin-C and Tenascin-R Retard Oligodendrocyte Precursor Maturation and Myelin Regeneration in a Cuprizone-Induced Long-Term Demyelination Animal Model.
  10. Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs.
    Title: Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs.
Submit: New GeneRIF Correction See all GeneRIFs (121)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (5) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC144208, MGC144209

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
  
enables integrin binding ISO
Inferred from Sequence Orthology
more info
  
enables syndecan binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in bud outgrowth involved in lung branching ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mesenchymal-epithelial cell signaling involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peripheral nervous system axon regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within prostate gland epithelium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell migration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to wounding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basement membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in interstitial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in perisynaptic extracellular matrix EXP
Inferred from Experiment
more info
 PubMed 
is_active_in perisynaptic extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perisynaptic extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
part_of tenascin complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
tenascin
Names
hexabrachion

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369211.1 → NP_001356140.1  tenascin isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL732556
    Consensus CDS
    CCDS89763.1
    UniProtKB/Swiss-Prot
    Q64706, Q80YX1, Q80YX2
    Related
    ENSMUSP00000102995.2, ENSMUST00000107372.8
    Conserved Domains (4) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00147
    Location:1889 → 2098
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:408 → 434
    EGF_2; EGF-like domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain

  2. NM_001369212.1 → NP_001356141.1  tenascin isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL732556
    UniProtKB/TrEMBL
    Q148T4
    Conserved Domains (4) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00147
    Location:1707 → 1916
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:408 → 434
    EGF_2; EGF-like domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain

  3. NM_001369213.1 → NP_001356142.1  tenascin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL732556
    Conserved Domains (4) summary
    cd00063
    Location:363 → 449
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00147
    Location:1537 → 1746
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:147 → 173
    EGF_2; EGF-like domain
    pfam00041
    Location:633 → 715
    fn3; Fibronectin type III domain

  4. NM_001369214.1 → NP_001356143.1  tenascin isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AL732556
    UniProtKB/TrEMBL
    Q148T4, Q148T5
    Conserved Domains (4) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00147
    Location:1343 → 1552
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:408 → 434
    EGF_2; EGF-like domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain

  5. NM_011607.3 → NP_035737.2  tenascin isoform 2 precursor

    See identical proteins and their annotated locations for NP_035737.2

    Status: VALIDATED

    Source sequence(s)
    AK040167, AL732556, BC117979, BY300535, CN664449
    Consensus CDS
    CCDS18265.1
    UniProtKB/Swiss-Prot
    Q80YX1
    UniProtKB/TrEMBL
    Q148T5, Q8C9Z1
    Related
    ENSMUSP00000103000.4, ENSMUST00000107377.10
    Conserved Domains (4) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:1798 → 2007
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:408 → 434
    EGF_2; EGF-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    63878022..63965554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537776.2 → XP_006537839.1  tenascin isoform X1

    UniProtKB/TrEMBL
    Q148T4
    Conserved Domains (6) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00147
    Location:1434 → 1643
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    pfam07974
    Location:345 → 372
    EGF_2; EGF-like domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam01414
    Location:516 → 558
    DSL; Delta serrate ligand
    pfam18720
    Location:408 → 435
    EGF_Tenascin; Tenascin EGF domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80YX1.1 GenPept UniProtKB/Swiss-Prot:Q80YX1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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