Btf3 basic transcription factor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Btf3provided by MGI
Official Full Name: basic transcription factor 3provided by MGI
Primary source: MGI:MGI:1202875
See related: Ensembl:ENSMUSG00000021660 AllianceGenome:MGI:1202875
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700054E11Rik
Summary: Acts upstream of or within in utero embryonic development. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytosol and polysomal ribosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human BTF3 (basic transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 136.7), placenta adult (RPKM 125.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D1; 13 51.92 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (98446405..98453514, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (98309897..98317006, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity.
Title: Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity.
Six putative caspase substrates, including five novel proteins (ABCF1, AKAP1, CPE, DOPEY1 and GOPC1) that may be targeted specifically by the initiator caspases 8 and 10 during the early stages of apoptosis, were identified.[caspase 10]
Title: Genome-wide screening and identification of novel proteolytic cleavage targets of caspase-8 and -10 in vitro.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Btf3 (e-PCR), detects polymorphism
- UniSTS:547194

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein localization to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of nascent polypeptide-associated complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nascent polypeptide-associated complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor BTF3

Names: NAC-beta; RNA polymerase B transcription factor 3; nascent polypeptide-associated complex subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170540.1 → NP_001164011.1 transcription factor BTF3 isoform 2

See identical proteins and their annotated locations for NP_001164011.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

AK139664, BC064010, CJ073405

Consensus CDS

CCDS49340.1

UniProtKB/TrEMBL

Q3UJR8

Related

ENSMUSP00000118093.2, ENSMUST00000152704.8

Conserved Domains (1) summary

cd22055
Location:9 → 125

NAC_BTF3; basal transcription factor BTF3
NM_145455.3 → NP_663430.2 transcription factor BTF3 isoform 1

See identical proteins and their annotated locations for NP_663430.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).

Source sequence(s)

BC064010

Consensus CDS

CCDS26714.1

UniProtKB/Swiss-Prot

Q64152, Q64153, Q6GU63, Q6P3F3

Related

ENSMUSP00000022163.9, ENSMUST00000022163.15

Conserved Domains (1) summary

pfam01849
Location:85 → 138

NAC; NAC domain