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Dglucy D-glutamate cyclase [ Mus musculus (house mouse) ]

Gene ID: 217830, updated on 21-Apr-2024

Summary

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Official Symbol
Dglucyprovided by MGI
Official Full Name
D-glutamate cyclaseprovided by MGI
Primary source
MGI:MGI:2444813
See related
Ensembl:ENSMUSG00000021185 AllianceGenome:MGI:2444813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9030617O03Rik
Summary
Enables D-glutamate cyclase activity. Involved in glutamate metabolic process. Located in mitochondrial matrix. Is expressed in several structures, including adipose tissue; heart; liver; lung; and spleen. Orthologous to human DGLUCY (D-glutamate cyclase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 29.1), heart adult (RPKM 15.1) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 E; 12 51.1 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (100745316..100838869)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (100779057..100872610)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33061 Neighboring gene predicted gene 2614 Neighboring gene STARR-seq mESC enhancer starr_33064 Neighboring gene predicted gene, 40558 Neighboring gene predicted gene, 25801 Neighboring gene STARR-seq mESC enhancer starr_33068 Neighboring gene STARR-positive B cell enhancer ABC_E8500 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene G protein-coupled receptor 68 Neighboring gene predicted gene, 36572 Neighboring gene coiled-coil domain containing 88C Neighboring gene RIKEN cDNA A630072L19 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. (D)-Glutamate is metabolized in the heart mitochondria. Ariyoshi M, et al. Sci Rep, 2017 Mar 7. PMID 28266638, Free PMC Article
  2. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  3. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • 9030617O03Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-glutamate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-glutamate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutamate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
D-glutamate cyclase, mitochondrial
Names
UPF0317 protein C14orf159 homolog, mitochondrial
NP_001347946.1
NP_001347949.1
NP_001347952.1
NP_663423.2
XP_006515799.1
XP_006515801.1
XP_030102529.1
XP_036013235.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001361017.1 → NP_001347946.1  D-glutamate cyclase, mitochondrial isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC126262, AC159818, BP765469
    Consensus CDS
    CCDS88389.1
    UniProtKB/TrEMBL
    E9QMK9, Q3U7K4
    Related
    ENSMUSP00000105700.2, ENSMUST00000110073.8
    Conserved Domains (2) summary
    pfam07286
    Location:145 → 285
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:329 → 639
    DUF4392; Domain of unknown function (DUF4392)

  2. NM_001361020.1 → NP_001347949.1  D-glutamate cyclase, mitochondrial isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Both variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC126262, AC159818
    Consensus CDS
    CCDS26108.1
    UniProtKB/Swiss-Prot
    Q8BH86, Q8BNN0, Q8VC99
    UniProtKB/TrEMBL
    Q3U7K4
    Related
    ENSMUSP00000105696.2, ENSMUST00000110069.8
    Conserved Domains (2) summary
    pfam07286
    Location:115 → 255
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:299 → 610
    DUF4392; Domain of unknown function (DUF4392)

  3. NM_001361023.1 → NP_001347952.1  D-glutamate cyclase, mitochondrial isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC126262, AC159818
    Conserved Domains (2) summary
    pfam07286
    Location:2 → 142
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:186 → 496
    DUF4392; Domain of unknown function (DUF4392)

  4. NM_145448.5 → NP_663423.2  D-glutamate cyclase, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_663423.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Both variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC126262, AC159818, AK033551, AK038436
    Consensus CDS
    CCDS26108.1
    UniProtKB/Swiss-Prot
    Q8BH86, Q8BNN0, Q8VC99
    UniProtKB/TrEMBL
    Q3U7K4
    Related
    ENSMUSP00000067830.5, ENSMUST00000069782.11
    Conserved Domains (2) summary
    pfam07286
    Location:115 → 255
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:299 → 610
    DUF4392; Domain of unknown function (DUF4392)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    100745316..100838869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515736.4 → XP_006515799.1  D-glutamate cyclase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    Q3U7K4
    Conserved Domains (2) summary
    pfam07286
    Location:126 → 266
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:310 → 621
    DUF4392; Domain of unknown function (DUF4392)

  2. XM_006515738.3 → XP_006515801.1  D-glutamate cyclase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006515801.1

    UniProtKB/Swiss-Prot
    Q8BH86, Q8BNN0, Q8VC99
    UniProtKB/TrEMBL
    Q3U7K4
    Related
    ENSMUSP00000129876.2, ENSMUST00000167322.2
    Conserved Domains (2) summary
    pfam07286
    Location:115 → 255
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:299 → 610
    DUF4392; Domain of unknown function (DUF4392)

  3. XM_036157342.1 → XP_036013235.1  D-glutamate cyclase, mitochondrial isoform X3

    Conserved Domains (2) summary
    pfam07286
    Location:2 → 142
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:186 → 496
    DUF4392; Domain of unknown function (DUF4392)

  4. XM_030246669.2 → XP_030102529.1  D-glutamate cyclase, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q8BH86, Q8BNN0, Q8VC99
    UniProtKB/TrEMBL
    Q3U7K4
    Conserved Domains (2) summary
    pfam07286
    Location:115 → 255
    DUF1445; Protein of unknown function (DUF1445)
    pfam14336
    Location:299 → 610
    DUF4392; Domain of unknown function (DUF4392)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH86.1 GenPept UniProtKB/Swiss-Prot:Q8BH86

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