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Tex261 testis expressed gene 261 [ Mus musculus (house mouse) ]

Gene ID: 21766, updated on 11-Apr-2024

Summary

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Official Symbol
Tex261provided by MGI
Official Full Name
testis expressed gene 261provided by MGI
Primary source
MGI:MGI:1096575
See related
Ensembl:ENSMUSG00000014748 AllianceGenome:MGI:1096575
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TEG-261; 3110001O07Rik
Summary
Predicted to enable COPII receptor activity. Acts upstream of or within positive regulation of apoptotic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in COPII-coated ER to Golgi transport vesicle. Predicted to be integral component of Golgi membrane and integral component of endoplasmic reticulum membrane. Is expressed in testis. Orthologous to human TEX261 (testis expressed 261). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 63.8), ovary adult (RPKM 52.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tex261 in Genome Data Viewer
Location:
6 C3; 6 35.94 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83745863..83752804, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83768881..83776099, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700124L16 gene Neighboring gene ankyrin repeat domain 53 Neighboring gene predicted gene, 52907 Neighboring gene 60S ribosomal protein L27 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tex261 modulates the excitotoxic cell death induced by N-methyl-D-aspartate (NMDA) receptor activation. Taniura H, et al. Biochem Biophys Res Commun, 2007 Nov 3. PMID 17803966
  2. Tex261, a novel gene presumably related but distinct from steroidogenic acute regulatory (StAR) gene, is regulated during the development of germ cells. López-Fernández LA, et al. Biochem Biophys Res Commun, 1998 Jan 26. PMID 9464256
  3. Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. López-Fernández LA, et al. Mamm Genome, 1996 Sep. PMID 8703127
  4. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings suggest that Tex261 modulates the excitotoxic cell death induced by NMDA receptor activation.
    Title: Tex261 modulates the excitotoxic cell death induced by N-methyl-D-aspartate (NMDA) receptor activation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables COPII receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein TEX261
Names
testis-expressed protein 261
testis-expressed sequence 261 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009357.2 → NP_033383.1  protein TEX261

    See identical proteins and their annotated locations for NP_033383.1

    Status: VALIDATED

    Source sequence(s)
    AK149789, BB526853, BY250528
    Consensus CDS
    CCDS20285.1
    UniProtKB/Swiss-Prot
    Q62302
    Related
    ENSMUSP00000014892.7, ENSMUST00000014892.8
    Conserved Domains (1) summary
    pfam04148
    Location:1 → 186
    Erv26; Transmembrane adaptor Erv26

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83745863..83752804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505886.4 → XP_006505949.1  protein TEX261 isoform X1

    See identical proteins and their annotated locations for XP_006505949.1

    Conserved Domains (1) summary
    pfam04148
    Location:1 → 139
    Erv26; Transmembrane adaptor Erv26

  2. XM_006505888.5 → XP_006505951.1  protein TEX261 isoform X2

    Conserved Domains (1) summary
    pfam04148
    Location:1 → 123
    Erv26; Transmembrane adaptor Erv26

  3. XM_030255311.1 → XP_030111171.1  protein TEX261 isoform X1

    Conserved Domains (1) summary
    pfam04148
    Location:1 → 139
    Erv26; Transmembrane adaptor Erv26
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62302.1 GenPept UniProtKB/Swiss-Prot:Q62302

Gene LinkOut

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