U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tesk1 testis specific protein kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 21754, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Tesk1provided by MGI
Official Full Name
testis specific protein kinase 1provided by MGI
Primary source
MGI:MGI:1201675
See related
Ensembl:ENSMUSG00000028458 AllianceGenome:MGI:1201675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable protein C-terminus binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Involved in glomerular visceral epithelial cell migration; negative regulation of phosphorylation; and regulation of actin cytoskeleton organization. Predicted to be located in centrosome and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with cytoplasmic vesicle. Orthologous to human TESK1 (testis associated actin remodelling kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 319.6), adrenal adult (RPKM 38.4) and 14 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4 A5; 4 23.04 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (43442277..43448075)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (43442277..43448075)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RUN and SH3 domain containing 2 Neighboring gene predicted gene, 52698 Neighboring gene STARR-seq mESC enhancer starr_10053 Neighboring gene ciliary microtubule inner protein 2B Neighboring gene CD72 antigen Neighboring gene STARR-positive B cell enhancer ABC_E2109 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:43495064-43495217 Neighboring gene STARR-positive B cell enhancer ABC_E834 Neighboring gene suppression inducing transmembrane adaptor 1 Neighboring gene RNA component of mitochondrial RNAase P

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Cell-type-specific expression of a TESK1 promoter-linked lacZ gene in transgenic mice. Toshima J, et al. Biochem Biophys Res Commun, 2001 Aug 24. PMID 11511097
  2. Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1). Wang L, et al. Sci Rep, 2018 Aug 16. PMID 30115939, Free PMC Article
  3. Structural organization and chromosomal localization of the mouse tesk1 (testis-specific protein kinase 1) gene. Toshima J, et al. Gene, 1998 Jan 12. PMID 9469938
  4. Deletion of Limk1 and Limk2 in mice does not alter cochlear development or auditory function. Fang Q, et al. Sci Rep, 2019 Mar 4. PMID 30833597, Free PMC Article
  5. Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling. Chandramouli S, et al. J Biol Chem, 2008 Jan 18. PMID 17974561

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment of vesicle localization ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in podocyte cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of stress fiber assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dual specificity testis-specific protein kinase 1
Names
testicular protein kinase 1
NP_035701.3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011571.3 → NP_035701.3  dual specificity testis-specific protein kinase 1

    See identical proteins and their annotated locations for NP_035701.3

    Status: VALIDATED

    Source sequence(s)
    AK144302, BB325506, BC099699
    Consensus CDS
    CCDS18094.1
    UniProtKB/Swiss-Prot
    O70146, O70147, Q499W7
    Related
    ENSMUSP00000050087.7, ENSMUST00000060864.13
    Conserved Domains (2) summary
    smart00219
    Location:56 → 306
    TyrKc; Tyrosine kinase, catalytic domain
    cd14155
    Location:58 → 312
    PKc_TESK; Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    43442277..43448075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70146.3 GenPept UniProtKB/Swiss-Prot:O70146

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous