Uts2r urotensin 2 receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uts2rprovided by MGI
Official Full Name: urotensin 2 receptorprovided by MGI
Primary source: MGI:MGI:2183450
See related: Ensembl:ENSMUSG00000039321 AllianceGenome:MGI:2183450
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UTR; UTR2; Gpr14; UR-2-R
Summary: Predicted to enable urotensin II receptor activity. Predicted to be involved in several processes, including positive regulation of circadian sleep/wake cycle, REM sleep; positive regulation of circadian sleep/wake cycle, wakefulness; and regulation of blood pressure. Predicted to act upstream of or within signal transduction. Predicted to be located in early endosome; plasma membrane; and recycling endosome. Predicted to be integral component of plasma membrane. Orthologous to human UTS2R (urotensin 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 85.02 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (121051097..121052799)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (121160271..121161973)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Urotensin receptor acts as a novel target for ameliorating fasting-induced skeletal muscle atrophy.
Title: Urotensin receptor acts as a novel target for ameliorating fasting-induced skeletal muscle atrophy.
The results of this study help to understand the inflammatory and therapeutic contribution of the UII/UTR system on sepsis-induced lung damage. We can suggest that UTR receptor antagonists may be evaluated as a potential drug which reduces sepsis-induced lung damage in the future.
Title: Urotensin receptors as a new target for CLP induced septic lung injury in mice.
role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions
Title: The role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions.
UII/UTR system plays a role in lipopolysaccharide (LPS)/D-galactosamine (GalN)-induced acute liver failure.
Title: Inhibition of UII/UTR system relieves acute inflammation of liver through preventing activation of NF-κB pathway in ALF mice.
findings demonstrate an important role for UII in the pathogenesis of the metabolic syndrome and suggest that the use of UT receptor antagonists may provide a new therapeutic tool for the treatment of this syndrome
Title: Blocking the urotensin II receptor pathway ameliorates the metabolic syndrome and improves cardiac function in obese mice.
a new urotensin II receptor signalling pathway which is mediated by EGFR trans-activation, dependent by beta-arrestin 1/2, promoting cell survival and cardioprotection.
Title: EGFR trans-activation by urotensin II receptor is mediated by β-arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy.
In addition to its role at the neuromuscular junction, urotensin II may control motor function through the modulation of motoneuron activity within the spinal cord.
Title: Urotensin II receptor and acetylcholine release from mouse cervical spinal cord nerve terminals.
Urotensin II receptor knockout mice on an ApoE knockout background fed a high-fat diet exhibit an enhanced hyperlipidemic and atherosclerotic phenotype.
Title: Urotensin II receptor knockout mice on an ApoE knockout background fed a high-fat diet exhibit an enhanced hyperlipidemic and atherosclerotic phenotype.
Elevated expression of Uts2r in skeletal muscle of diabetic mouse is repoted.
Title: Elevated expression of urotensin II and its receptor in skeletal muscle of diabetic mouse.
In the CNS Utsr mRNAs are expressed in brainstem and spinal motoneurons,the medial vestibular nucleus, locus coeruleus and the ventral medulla.In periphery,mRNAs are expressed in skeletal muscle, testis, vagina, stomach, and gall bladder,prostate.
Title: Characterization of urotensin II, distribution of urotensin II, urotensin II-related peptide and UT receptor mRNAs in mouse: evidence of urotensin II at the neuromuscular junction.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487692

NoName (e-PCR)
- UniSTS:494047

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables urotensin II receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables urotensin II receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of urine volume	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian sleep/wake cycle, REM sleep	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of circadian sleep/wake cycle, wakefulness	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: urotensin-2 receptor

Names: G protein-coupled receptor 14; UR-II-R; urotensin II receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.