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Mgl2 macrophage galactose N-acetyl-galactosamine specific lectin 2 [ Mus musculus (house mouse) ]

Gene ID: 216864, updated on 8-Feb-2024

Summary

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Official Symbol
Mgl2provided by MGI
Official Full Name
macrophage galactose N-acetyl-galactosamine specific lectin 2provided by MGI
Primary source
MGI:MGI:2385729
See related
Ensembl:ENSMUSG00000040950 AllianceGenome:MGI:2385729
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD301b
Summary
Enables carbohydrate binding activity. Predicted to be active in external side of plasma membrane. Is expressed in ductus deferens; epididymis; ileum; prostate gland; and testis. Orthologous to human CLEC10A (C-type lectin domain containing 10A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 12.3), mammary gland adult (RPKM 12.0) and 14 other tissues See more
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Genomic context

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Location:
11 B3; 11 42.99 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70020953..70028368)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70130125..70137542)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32946 Neighboring gene asialoglycoprotein receptor 2 Neighboring gene predicted gene 12311 Neighboring gene STARR-seq mESC enhancer starr_29870 Neighboring gene C-type lectin domain family 10, member A Neighboring gene STARR-seq mESC enhancer starr_29871 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Macrophage Gal/GalNAc lectin 2 (MGL2)(+) peritoneal antigen presenting cells during Fasciola hepatica infection are essential for regulatory T cell induction. Costa M, et al. Sci Rep, 2022 Oct 21. PMID 36271272, Free PMC Article
  2. The Tn antigen promotes lung tumor growth by fostering immunosuppression and angiogenesis via interaction with Macrophage Galactose-type lectin 2 (MGL2). da Costa V, et al. Cancer Lett, 2021 Oct 10. PMID 34144098
  3. CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity. Kumamoto Y, et al. Immunity, 2013 Oct 17. PMID 24076051, Free PMC Article
  4. Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells. Denda-Nagai K, et al. J Biol Chem, 2010 Jun 18. PMID 20304916, Free PMC Article
  5. MGL2 Dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo. Kumamoto Y, et al. PLoS One, 2009. PMID 19440334, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD301b[+] macrophage: the new booster for activating bone regeneration in periodontitis treatment.
    Title: CD301b(+) macrophage: the new booster for activating bone regeneration in periodontitis treatment.
  2. Effective CD4 T cell priming requires repertoire scanning by CD301b(+) migratory cDC2 cells upon lymph node entry.
    Title: Effective CD4 T cell priming requires repertoire scanning by CD301b(+) migratory cDC2 cells upon lymph node entry.
  3. The Tn antigen promotes lung tumor growth by fostering immunosuppression and angiogenesis via interaction with Macrophage Galactose-type lectin 2 (MGL2).
    Title: The Tn antigen promotes lung tumor growth by fostering immunosuppression and angiogenesis via interaction with Macrophage Galactose-type lectin 2 (MGL2).
  4. CD301b/MGL2(+) Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis.
    Title: CD301b/MGL2(+) Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis.
  5. Reconstituting RELMalpha in CD301b(+) MNP-depleted animals restored body weight.
    Title: CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha.
  6. CD301b dermal dendritic cells drive T helper 2 cell-mediated immunity.
    Title: CD301b⁺ dermal dendritic cells drive T helper 2 cell-mediated immunity.
  7. analysis of macrophage galactose-type C-type lectin 2 (MGL2/CD301b) uptake and presentation of glycosylated antigens by dendritic cells
    Title: Distribution and function of macrophage galactose-type C-type lectin 2 (MGL2/CD301b): efficient uptake and presentation of glycosylated antigens by dendritic cells.
  8. The results demonstrated the availability of MGL2 as a novel marker for DDCs and suggested the contribution of MGL2(+) DDCs for initiating CHS.
    Title: MGL2 Dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo.
  9. Mutations of MGL2 CRD at Leu, Arg, Arg, and Tyr at positions 61, 89, 115 and 125 were implicated in the preference for beta-GalNAc.
    Title: The amino acids involved in the distinct carbohydrate specificities between macrophage galactose-type C-type lectins 1 and 2 (CD301a and b) of mice.
  10. The mMGL2 protein is induced in diverse populations of aaMF, including peritoneal macrophages elicited during infection with the protozoan Trypanosoma brucei brucei or the Helminth Taenia crassiceps and alveolar macrophages elicited.
    Title: Macrophage galactose-type C-type lectins as novel markers for alternatively activated macrophages elicited by parasitic infections and allergic airway inflammation.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC123660, MGC123939, MGC124077

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables fucose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological process involved in interspecies interaction between organisms IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
macrophage galactose N-acetyl-galactosamine specific lectin 2
Names
macrophage galactose-type C-type lectin 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145137.2 → NP_660119.1  macrophage galactose N-acetyl-galactosamine specific lectin 2

    See identical proteins and their annotated locations for NP_660119.1

    Status: VALIDATED

    Source sequence(s)
    BC106833, BY198732, BY544307
    Consensus CDS
    CCDS24935.1
    UniProtKB/TrEMBL
    F6QSC4, Q8JZN1
    Related
    ENSMUSP00000048568.6, ENSMUST00000041550.12
    Conserved Domains (2) summary
    cd03590
    Location:189 → 314
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:38 → 179
    Lectin_N; Hepatic lectin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70020953..70028368
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532912.2 → XP_006532975.1  macrophage galactose N-acetyl-galactosamine specific lectin 2 isoform X1

    See identical proteins and their annotated locations for XP_006532975.1

    UniProtKB/TrEMBL
    A9XX86, F6QSC4
    Related
    ENSMUSP00000131344.2, ENSMUST00000165951.8
    Conserved Domains (2) summary
    cd03590
    Location:190 → 363
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:39 → 180
    Lectin_N; Hepatic lectin, N-terminal domain

  2. XM_006532913.4 → XP_006532976.1  macrophage galactose N-acetyl-galactosamine specific lectin 2 isoform X2

    See identical proteins and their annotated locations for XP_006532976.1

    UniProtKB/TrEMBL
    F6QSC4
    Related
    ENSMUSP00000104225.2, ENSMUST00000108584.2
    Conserved Domains (2) summary
    cd03590
    Location:189 → 362
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:38 → 179
    Lectin_N; Hepatic lectin, N-terminal domain

  3. XM_006532915.2 → XP_006532978.1  macrophage galactose N-acetyl-galactosamine specific lectin 2 isoform X5

    See identical proteins and their annotated locations for XP_006532978.1

    UniProtKB/TrEMBL
    F6QSC4
    Conserved Domains (2) summary
    cd03590
    Location:190 → 315
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:39 → 180
    Lectin_N; Hepatic lectin, N-terminal domain

  4. XM_017314459.1 → XP_017169948.1  macrophage galactose N-acetyl-galactosamine specific lectin 2 isoform X4

    UniProtKB/TrEMBL
    Q8BUD5
    Conserved Domains (2) summary
    cd03590
    Location:159 → 332
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:2 → 149
    Lectin_N; Hepatic lectin, N-terminal domain

  5. XM_006532914.4 → XP_006532977.1  macrophage galactose N-acetyl-galactosamine specific lectin 2 isoform X3

    See identical proteins and their annotated locations for XP_006532977.1

    UniProtKB/TrEMBL
    Q8BUD5
    Conserved Domains (2) summary
    cd03590
    Location:160 → 333
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    pfam03954
    Location:2 → 150
    Lectin_N; Hepatic lectin, N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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