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Tom1l2 target of myb1-like 2 (chicken) [ Mus musculus (house mouse) ]

Gene ID: 216810, updated on 21-Apr-2024

Summary

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Official Symbol
Tom1l2provided by MGI
Official Full Name
target of myb1-like 2 (chicken)provided by MGI
Primary source
MGI:MGI:2443306
See related
Ensembl:ENSMUSG00000000538 AllianceGenome:MGI:2443306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Srebf1; 2900016I08Rik; A730055F12Rik
Summary
Predicted to enable clathrin binding activity and protein kinase binding activity. Predicted to be involved in negative regulation of mitotic nuclear division and signal transduction. Predicted to act upstream of or within protein transport. Predicted to be active in endosome and membrane. Orthologous to human TOM1L2 (target of myb1 like 2 membrane trafficking protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 35.6), cortex adult (RPKM 28.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B2; 11 37.81 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (60114622..60243766, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (60226714..60352932, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10678 Neighboring gene microRNA 6921 Neighboring gene microRNA 6922 Neighboring gene sterol regulatory element binding transcription factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E11767 Neighboring gene predicted gene, 38501 Neighboring gene STARR-seq mESC enhancer starr_29644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:60147838-60148039 Neighboring gene STARR-positive B cell enhancer ABC_E77 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_29650 Neighboring gene dynein regulatory complex subunit 3 Neighboring gene STARR-positive B cell enhancer ABC_E1139 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene STARR-seq mESC enhancer starr_29653 Neighboring gene STARR-seq mESC enhancer starr_29654 Neighboring gene GID complex subunit 4, VID24 homolog Neighboring gene predicted gene 12268

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tom1l2 hypomorphic mice exhibit increased incidence of infections and tumors and abnormal immunologic response. Girirajan S, et al. Mamm Genome, 2008 Apr. PMID 18343975
  2. The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia. Shinde SR, et al. Dev Cell, 2023 Apr 24. PMID 37019113,
  3. Hepatic free fatty acids accumulate in experimental steatohepatitis: role of adaptive pathways. Larter CZ, et al. J Hepatol, 2008 Apr. PMID 18280001
  4. Phenotypic consequences of copy number variation: insights from Smith-Magenis and Potocki-Lupski syndrome mouse models. Ricard G, et al. PLoS Biol, 2010 Nov 23. PMID 21124890, Free PMC Article
  5. Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. Bi W, et al. Genome Res, 2002 May. PMID 11997338, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia.
    Title: The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia.
  2. Consistent with pathways of hepatic triglyceride synthesis, expression of diacylglycerol acyltransferase-1 and -2 was increased, as were delta-5- and delta-6- fatty acid desaturase mRNA levels.
    Title: Hepatic free fatty acids accumulate in experimental steatohepatitis: role of adaptive pathways.
  3. Tom1l2plays a role in the immune response and possibly in tumor suppression.
    Title: Tom1l2 hypomorphic mice exhibit increased incidence of infections and tumors and abnormal immunologic response.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TOM1-like protein 2
Names
myb1-like protein 2
target of Myb-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039092.4 → NP_001034181.1  TOM1-like protein 2 isoform b

    See identical proteins and their annotated locations for NP_001034181.1

    Status: VALIDATED

    Source sequence(s)
    AI848036, AL596090, BC127266
    Consensus CDS
    CCDS36171.1
    UniProtKB/TrEMBL
    Q5SXA4
    Related
    ENSMUSP00000092884.6, ENSMUST00000095254.12
    Conserved Domains (2) summary
    cd03565
    Location:12 → 152
    VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
    cd14238
    Location:218 → 309
    GAT_TM1L2; GAT domain found in target of Myb-like protein 2 (Tom1L2)

  2. NM_001039093.1 → NP_001034182.1  TOM1-like protein 2 isoform c

    See identical proteins and their annotated locations for NP_001034182.1

    Status: VALIDATED

    Source sequence(s)
    AK043095, AK054531, AL596090
    Consensus CDS
    CCDS24787.1
    UniProtKB/TrEMBL
    Q5SXA4
    Related
    ENSMUSP00000099743.5, ENSMUST00000102682.5
    Conserved Domains (2) summary
    cd03565
    Location:12 → 152
    VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
    cd14238
    Location:218 → 309
    GAT_TM1L2; GAT domain found in target of Myb-like protein 2 (Tom1L2)

  3. NM_001359810.1 → NP_001346739.1  TOM1-like protein 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AK043095, AL596090, AL669954
    Consensus CDS
    CCDS88165.1
    UniProtKB/TrEMBL
    Q5SXA4
    Related
    ENSMUSP00000063414.9, ENSMUST00000064019.15
    Conserved Domains (2) summary
    cd03565
    Location:12 → 152
    VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
    cd14238
    Location:218 → 309
    GAT_TM1L2; GAT domain found in target of Myb-like protein 2 (Tom1L2)

  4. NM_001403888.1 → NP_001390817.1  TOM1-like protein 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AL596090, AL669954

  5. NM_001403891.1 → NP_001390820.1  TOM1-like protein 2 isoform f

    Status: VALIDATED

    Source sequence(s)
    AL596090, AL669954

  6. NM_001403893.1 → NP_001390822.1  TOM1-like protein 2 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL596090, AL669954

  7. NM_001403895.1 → NP_001390824.1  TOM1-like protein 2 isoform g

    Status: VALIDATED

    Source sequence(s)
    AL596090, AL669954

  8. NM_001403896.1 → NP_001390825.1  TOM1-like protein 2 isoform i

    Status: VALIDATED

    Source sequence(s)
    AL596090, AL669954

  9. NM_153080.3 → NP_694720.2  TOM1-like protein 2 isoform a

    See identical proteins and their annotated locations for NP_694720.2

    Status: VALIDATED

    Source sequence(s)
    AF467887, AI848036, AL596090, AL669954, BC127266
    Consensus CDS
    CCDS24786.1
    UniProtKB/Swiss-Prot
    A0JP66, Q5SRX1, Q5SRX7, Q5SRY0, Q6P5D7, Q8C6J0, Q8C935, Q8CB51, Q8R4H1
    UniProtKB/TrEMBL
    Q5SXA4
    Related
    ENSMUSP00000099744.5, ENSMUST00000102683.11
    Conserved Domains (2) summary
    cd03565
    Location:12 → 152
    VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
    cd14238
    Location:218 → 309
    GAT_TM1L2; GAT domain found in target of Myb-like protein 2 (Tom1L2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    60114622..60243766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156554.1 → XP_036012447.1  TOM1-like protein 2 isoform X6

    UniProtKB/TrEMBL
    Q5SXA4
    Conserved Domains (2) summary
    cd16996
    Location:12 → 148
    VHS_Tom1L2; VHS (Vps27/Hrs/STAM) domain of TOM1-like protein 2
    cd14238
    Location:218 → 309
    GAT_TM1L2; canonical GAT domain found in target of Myb-like protein 2 (Tom1L2)

  2. XM_011248906.4 → XP_011247208.1  TOM1-like protein 2 isoform X2

    UniProtKB/TrEMBL
    Q5SXA4
    Conserved Domains (2) summary
    cd14238
    Location:218 → 309
    GAT_TM1L2; GAT domain found in target of Myb-like protein 2 (Tom1L2)
    cd16996
    Location:12 → 148
    VHS_Tom1L2; VHS (Vps27/Hrs/STAM) domain of TOM1-like protein 2

  3. XM_030245804.1 → XP_030101664.1  TOM1-like protein 2 isoform X3

    UniProtKB/TrEMBL
    Q5SXA4
    Conserved Domains (2) summary
    cd14238
    Location:185 → 276
    GAT_TM1L2; GAT domain found in target of Myb-like protein 2 (Tom1L2)
    cl02544
    Location:1 → 115
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily

  4. XM_030245805.1 → XP_030101665.1  TOM1-like protein 2 isoform X3

    UniProtKB/TrEMBL
    Q5SXA4
    Conserved Domains (2) summary
    cd14238
    Location:185 → 276
    GAT_TM1L2; GAT domain found in target of Myb-like protein 2 (Tom1L2)
    cl02544
    Location:1 → 115
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily

  5. XM_017314451.3 → XP_017169940.1  TOM1-like protein 2 isoform X7

    Conserved Domains (2) summary
    cd14238
    Location:185 → 276
    GAT_TM1L2; GAT domain found in target of Myb-like protein 2 (Tom1L2)
    cl02544
    Location:1 → 115
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SRX1.1 GenPept UniProtKB/Swiss-Prot:Q5SRX1

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