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Tead2 TEA domain family member 2 [ Mus musculus (house mouse) ]

Gene ID: 21677, updated on 5-Mar-2024

Summary

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Official Symbol
Tead2provided by MGI
Official Full Name
TEA domain family member 2provided by MGI
Primary source
MGI:MGI:104904
See related
Ensembl:ENSMUSG00000030796 AllianceGenome:MGI:104904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ETF; Etdf; TEF4; TEF-4; ETEF-1; TEAD-2
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of cell death. Acts upstream of or within several processes, including cellular response to retinoic acid; mesenchyme development; and tube morphogenesis. Part of transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and limb bud. Orthologous to human TEAD2 (TEA domain transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 109.8), limb E14.5 (RPKM 100.2) and 12 other tissues See more
Orthologs
human all
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Genomic context

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See Tead2 in Genome Data Viewer
Location:
7 B3; 7 29.19 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (44865216..44882892)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45215792..45233468)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene KASH domain containing 5 Neighboring gene predicted gene, 31097 Neighboring gene STARR-positive B cell enhancer ABC_E10438 Neighboring gene dickkopf-like 1 Neighboring gene STARR-seq mESC enhancer starr_18834 Neighboring gene STARR-positive B cell enhancer ABC_E872 Neighboring gene STARR-seq mESC enhancer starr_18835 Neighboring gene CD37 antigen Neighboring gene solute carrier family 6, member 16 Neighboring gene predicted gene, 23585

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis. Park S, et al. Mol Cell, 2022 Nov 17. PMID 36400009
  2. Identification of novel Taz isoforms and functional comparison in pluripotency maintenance of mouse embryonic stem cells. Xu Y, et al. Gene, 2021 Mar 20. PMID 33383118
  3. Soggy, a spermatocyte-specific gene, lies 3.8 kb upstream of and antipodal to TEAD-2, a transcription factor expressed at the beginning of mouse development. Kaneko KJ, et al. Nucleic Acids Res, 2000 Oct 15. PMID 11024178, Free PMC Article
  4. The transcription factor, Kid-1, is highly expressed in both eye and kidney of the mouse. Brady JP, et al. Exp Eye Res, 1997 Feb. PMID 9176064
  5. Molecular characterization of cDNA encoding a novel protein related to transcriptional enhancer factor-1 from neural precursor cells. Yasunami M, et al. J Biol Chem, 1995 Aug 4. PMID 7629195

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.
    Title: Comparative expression analysis of TEADs and their splice variants in mouse embryonic stem cells.
  2. Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis.
    Title: Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis.
  3. Identification of novel Taz isoforms and functional comparison in pluripotency maintenance of mouse embryonic stem cells.
    Title: Identification of novel Taz isoforms and functional comparison in pluripotency maintenance of mouse embryonic stem cells.
  4. Tead transcription factors differentially regulate cortical development.
    Title: Tead transcription factors differentially regulate cortical development.
  5. Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mouse mesoderm.
    Title: Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm.
  6. Cells with reduced Tead activity became losers, whereas cells with increased Tead activity became super-competitors. Tead directly regulated Myc RNA expression, and cells with increased Myc expression also became super-competitors.
    Title: Cell competition in mouse NIH3T3 embryonic fibroblasts is controlled by the activity of Tead family proteins and Myc.
  7. Tead2 transcription factors are crucial regulators of the cellular distribution of Yap and Taz, and together they control the expression of genes critical for EMT and metastasis.
    Title: Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition.
  8. serum also activates TEAD-dependent transcription in a time- and dose-dependent manner and we identify Inter-alpha-inhibitor (IalphaI) as a component in serum capable of activating the Yes/YAP/TEAD pathway
    Title: Serum Inter-α-inhibitor activates the Yes tyrosine kinase and YAP/TEAD transcriptional complex in mouse embryonic stem cells.
  9. These findings provide proof of principle that inhibiting TEAD-YAP interactions is a pharmacologically viable strategy against the YAP oncoprotein.
    Title: Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP.
  10. YAP, TEAD2 and Yes are highly expressed in self-renewing embryonic stem cells, and are activated by LIF.
    Title: Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to retinoic acid IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within embryonic heart tube morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lateral mesoderm development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mesenchyme development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nervous system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within notochord development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within paraxial mesoderm development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within vasculogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of TEAD-YAP complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcriptional enhancer factor TEF-4
Names
embryonic TEA domain-containing factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285498.2 → NP_001272427.1  transcriptional enhancer factor TEF-4 isoform a

    See identical proteins and their annotated locations for NP_001272427.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 2, 4, and 5, encodes the longer isoform (a).
    Source sequence(s)
    AC150897
    Consensus CDS
    CCDS21236.1
    UniProtKB/Swiss-Prot
    P48301, Q62297
    UniProtKB/TrEMBL
    Q3UMJ5, Q3UPV9
    Conserved Domains (2) summary
    smart00426
    Location:40 → 107
    TEA; TEA domain
    pfam17725
    Location:226 → 442
    YBD; YAP binding domain

  2. NM_001285500.2 → NP_001272429.1  transcriptional enhancer factor TEF-4 isoform b

    See identical proteins and their annotated locations for NP_001272429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC150897
    Consensus CDS
    CCDS71957.1
    UniProtKB/TrEMBL
    Q3UMJ5, Q80UL2
    Related
    ENSMUSP00000103430.2, ENSMUST00000097216.5
    Conserved Domains (1) summary
    cl02603
    Location:43 → 72
    TEA; TEA/ATTS domain family

  3. NM_001379272.1 → NP_001366201.1  transcriptional enhancer factor TEF-4 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (a). Variants 1, 2, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AC150897
    UniProtKB/Swiss-Prot
    P48301, Q62297
    UniProtKB/TrEMBL
    Q3UMJ5, Q3UPV9
    Related
    ENSMUSP00000103431.2, ENSMUST00000107801.10
    Conserved Domains (2) summary
    smart00426
    Location:40 → 107
    TEA; TEA domain
    pfam17725
    Location:226 → 442
    YBD; YAP binding domain

  4. NM_001379273.1 → NP_001366202.1  transcriptional enhancer factor TEF-4 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 2, and 4, encodes the longer isoform (a).
    Source sequence(s)
    AC150897
    UniProtKB/Swiss-Prot
    P48301, Q62297
    UniProtKB/TrEMBL
    Q3UMJ5, Q3UPV9
    Conserved Domains (2) summary
    smart00426
    Location:40 → 107
    TEA; TEA domain
    pfam17725
    Location:226 → 442
    YBD; YAP binding domain

  5. NM_011565.3 → NP_035695.1  transcriptional enhancer factor TEF-4 isoform a

    See identical proteins and their annotated locations for NP_035695.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, and 5 all encode the same isoform (a).
    Source sequence(s)
    AC150897
    Consensus CDS
    CCDS21236.1
    UniProtKB/Swiss-Prot
    P48301, Q62297
    UniProtKB/TrEMBL
    Q3UMJ5, Q3UPV9
    Related
    ENSMUSP00000033060.7, ENSMUST00000033060.14
    Conserved Domains (2) summary
    smart00426
    Location:40 → 107
    TEA; TEA domain
    pfam17725
    Location:226 → 442
    YBD; YAP binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    44865216..44882892
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48301.1 GenPept UniProtKB/Swiss-Prot:P48301

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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