U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nmur2 neuromedin U receptor 2 [ Mus musculus (house mouse) ]

Gene ID: 216749, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Nmur2provided by MGI
Official Full Name
neuromedin U receptor 2provided by MGI
Primary source
MGI:MGI:2441765
See related
Ensembl:ENSMUSG00000037393 AllianceGenome:MGI:2441765
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nmu2r
Summary
Enables neuropeptide receptor activity. Acts upstream of or within several processes, including grooming behavior; neuropeptide signaling pathway; and reduction of food intake in response to dietary excess. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human NMUR2 (neuromedin U receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 1.4), subcutaneous fat pad adult (RPKM 1.0) and 8 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 B1.3; 11 33.39 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (55915816..55931813, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (56024990..56040987, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12236 Neighboring gene STARR-seq mESC enhancer starr_29547 Neighboring gene glycine receptor, alpha 1 subunit Neighboring gene STARR-seq mESC enhancer starr_29550 Neighboring gene STARR-seq mESC enhancer starr_29551 Neighboring gene STARR-seq mESC enhancer starr_29552 Neighboring gene STARR-seq mESC enhancer starr_29553 Neighboring gene predicted gene, 50502 Neighboring gene STARR-seq mESC enhancer starr_29554 Neighboring gene predicted gene 12239 Neighboring gene STARR-seq mESC enhancer starr_29558 Neighboring gene predicted gene, 46260 Neighboring gene predicted gene 12240 Neighboring gene predicted gene, 24253

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Neuromedin U receptor 2 does not play a role in the development of neuropathic pain following nerve injury in mice. Gilbert AK, et al. Eur J Pain, 2013 Sep. PMID 23349076
  2. Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice. Egecioglu E, et al. Am J Physiol Endocrinol Metab, 2009 Sep. PMID 19584200
  3. Neuromedin-U is regulated by the circadian clock in the SCN of the mouse. Graham ES, et al. Eur J Neurosci, 2005 Feb. PMID 15733101
  4. Cloning and characterization of murine neuromedin U receptors. Funes S, et al. Peptides, 2002 Sep. PMID 12217421
  5. Appetite-modifying actions of pro-neuromedin U-derived peptides. Bechtold DA, et al. Am J Physiol Endocrinol Metab, 2009 Aug. PMID 19531638, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis.
    Title: Postnatal ontogeny of Neuromedin S and its receptors NMUR1 and NMUR2 expression in mouse testis.
  2. Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents.
    Title: Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents.
  3. Neuromedin U (NMU) regulates osteoblast differentiation and activity.
    Title: Neuromedin U (NMU) regulates osteoblast differentiation and activity.
  4. The present data do not support a significant contribution of NMUR2 to the development of hypersensitivity after nerve injury or tissue inflammation
    Title: Neuromedin U receptor 2 does not play a role in the development of neuropathic pain following nerve injury in mice.
  5. Data show that deficiency of neuromedin receptors NMUR1 and NMUR2 had no impact on arthritis severity.
    Title: The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.
  6. Long-term central NMU treatment reduces body weight, food intake, and adiposity and that central NMUR2 signaling is required for these effects in female but not male mice.
    Title: Central NMU signaling in body weight and energy balance regulation: evidence from NMUR2 deletion and chronic central NMU treatment in mice.
  7. The circadian rhythm of neuromedin U expression in the suprachiasmatic nucleus does not drive a circadian rhythm of corticotrophin-releasing factor in the paraventricular nucleus.
    Title: Neuromedin-U is regulated by the circadian clock in the SCN of the mouse.
  8. molecular basis of the NMU2R regulation of food intake and body weight in mice
    Title: Chemical genetic analysis reveals the effects of NMU2R on the expression of peptide hormones.
  9. the pro-nociceptive effects of neuromedin U in mice appear to be mediated through NMUR2, not NMUR1
    Title: Mice genetically deficient in neuromedin U receptor 2, but not neuromedin U receptor 1, have impaired nociceptive responses.
  10. Plays a more significant role in central pain processing than other brain functions including stress/anxiety and regulation of feeding.
    Title: Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables intracellularly calcium-gated chloride channel activity ISO
Inferred from Sequence Orthology
more info
  
enables neuromedin U binding ISO
Inferred from Sequence Orthology
more info
  
enables neuromedin U receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables neuropeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables neuropeptide receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within grooming behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within reduction of food intake in response to dietary excess IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to pain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IC
Inferred by Curator
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
neuromedin-U receptor 2
Names
NMU-R2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153079.4 → NP_694719.2  neuromedin-U receptor 2

    See identical proteins and their annotated locations for NP_694719.2

    Status: PROVISIONAL

    Source sequence(s)
    AL671969
    Consensus CDS
    CCDS24716.1
    UniProtKB/Swiss-Prot
    Q8BZ39, Q91Z76
    UniProtKB/TrEMBL
    B2RPU9
    Related
    ENSMUSP00000044718.3, ENSMUST00000037682.3
    Conserved Domains (2) summary
    pfam00001
    Location:54 → 319
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:48 → 333
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    55915816..55931813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZ39.1 GenPept UniProtKB/Swiss-Prot:Q8BZ39

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous